A5069726997- Cardiac Valve Diseases and Treatments
- Pulmonary Hypertension Research and Treatments
- MicroRNA in disease regulation
- Smart Agriculture and AI
- Atrial Fibrillation Management and Outcomes
- Phonocardiography and Auscultation Techniques
- Parasitic Diseases Research and Treatment
- Cardiac electrophysiology and arrhythmias
- Traumatic Brain Injury and Neurovascular Disturbances
- Parasites and Host Interactions
- Cardiac Fibrosis and Remodeling
- Diverse Musicological Studies
- Cardiac Ischemia and Reperfusion
- Cardiac Arrest and Resuscitation
- Music and Audio Processing
- Cardiomyopathy and Myosin Studies
- Cardiovascular Issues in Pregnancy
- Neurological Disorders and Treatments
- Spectroscopy and Chemometric Analyses
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Cancer-related gene regulation
- RNA regulation and disease
- Inflammasome and immune disorders
- Leaf Properties and Growth Measurement
The First Affiliated Hospital, Sun Yat-sen University
2015-2025
Sun Yat-sen University
2015-2025
University of Tasmania
2023-2024
Fourth People's Hospital of Sichuan Province
2018
Shanghai Institute of Quality Inspection and Technical Research
2018
Shandong Special Equipment Inspection Institute
2018
Lanzhou Veterinary Research Institute
2013
Hangzhou Dianzi University
2012
Pulmonary artery hypertension (PAH) is characterized by vascular remodeling, high pulmonary blood pressure, and right ventricular hypertrophy. Oxidative stress, inflammation remodeling are important components in PAH. Ellagic acid (EA) a phenolic compound with anti-oxidative, anti-inflammatory, anti-proliferative properties. This study aimed to investigate whether EA could prevent the development of monocrotaline (MCT)-induced PAH rats.Male Sprague-Dawley rats received (30 50mg/kg/day) or...
Abstract The growing demand for sustainable development brings a series of information technologies to help agriculture production. Especially, the emergence machine learning applications, branch artificial intelligence, has shown multiple breakthroughs which can enhance and revolutionize plant pathology approaches. In recent years, been adopted leaf disease classification in both academic research industrial applications. Therefore, it is enormously beneficial researchers, engineers,...
Structural changes of the left and right atria associated with atrial fibrillation (AF) in mitral stenosis (MS) patients are well known, alterations microRNA (miRNA) expression profiles have also been investigated. However, miRNA still require delineation. This study evaluated tissues from MS AF relative to those normal sinus rhythm (NSR). Sample appendages were obtained 12 (6 AF) during valve replacement surgery. From these tissues, created analyzed using a human microarray. Results...
Ginsenosides exhibit various neuroprotective effects against oxidative stress. However, which ginsenoside provides optimal for the treatment of neurological disorders as a potent antioxidant remains to be elucidated. Therefore, present study investigated and compared Rb1, Rd, Rg1 Re ginsenosides on neural progenitor cells (NPCs) following tert-Butylhydroperoxide (t-BHP)-induced injury. Primary rat embryonic cortical NPCs were prepared from E14.5 embryos Sprague-Dawley rats. The injury model...
Objective— Myocardial injury during cardiac surgery is a major cause of perioperative morbidity and mortality. We determined whether statin therapy cardioprotective in patients undergoing noncoronary artery the potential mechanisms. Methods Results— One hundred fifty-one were randomly assigned to either group (n=77) or control (n=74). Simvastatin (20 mg) was administered preoperatively postoperatively. Plasma analyzed for troponin T, isoenzyme creatine kinase, C-reaction protein,...
The atrial fibrillation (AF) associated microRNAs (miRNAs) were found in the right atrium (RA) and left (LA) from patients with rheumatic mitral valve disease (RMVD). However, most studies only focus on RA; potential differences of AF-associated miRNAs between RA LA are still unknown. aim this study was to perform miRNA expression profiles analysis compare appendages (RAA) (LAA) RMVD patients.Samples tissues RAA LAA obtained 18 (10 AF) during replacement surgery. From these tissues, created...
Effective and non-toxic therapeutic agents are lacking for the prevention treatment of colitis. Previous studies found that methyl cinnamate (MC), extracted from galangal (
Abstract Background MicroRNAs were enrolled in various cardiovascular disease especially ischemic heart diseases, but the microRNA changes during myocardial ischemia reperfusion injury underwent cardiopulmonary bypass are still unknown. This study screens differences CPB canines and evaluates relationship of microRNAs with injury. Methods 13 healthy received 60 minutes aortic clamping cardioplegic arrest, followed by 90 reperfusion. Left ventricular samples, blood samples hemodynamic data...
Ischemic stroke, characterized by the disturbance of blood supply to brain, is a severe worldwide health threat with high mortality and morbidity. However, there no effective pharmacotherapy for ischemic injury. Currently, combined treatment highly recommended this devastating In present study, we investigated neuroprotective effects combination omega-3 polyunsaturated fatty acids (ω-3 PUFAs) Lyciumbarbarum polysaccharide (LBP) on cortical neurons using an in vitro model. Our study...
Toxoplasma kinase ROP18 is a key molecule responsible for the virulence of gondii; however, mechanisms by which exerts parasite via interaction with host proteins remain limited to small number identified substrates. To identify broader array substrates, we successfully purified bioactive mature and used it probe human proteome array. Sixty eight new putative targets were identified. Functional annotation analysis suggested that these have variety functions, including metabolic process,...
Objective: To determine the role of dishevelled binding antagonist beta catenin 1 (DACT1) in cytoskeletal arrangement cardiomyocytes atrial fibrillation (AF).Methods: The DACT1 expression and its associations with degree fibrosis β-catenin valvular disease patients were analyzed by immunohistochemistry Masson's staining.DACT1 was overexpressed myocyte cell line (HL-1) cardiac (H9C2) adenoviral vectors.Alterations fibrous actin (F-actin) content organization detected flow cytometry,...
Serum creatinine, an important diagnostic indicator for acute kidney injury (AKI), was considered to be a risk factor cardiovascular disease. This study aimed investigate the significance of postoperative serum creatinine in predicting prognosis cardiac surgery patients.The Medical Information Mart Intensive Care III (MIMIC-III) database used extract clinical data. Adult (≥18 years) patients were enrolled. The correlation with lengths intensive care unit (ICU) stay analyzed Spearman...
Pulmonary arterial hypertension (PAH) is a common complication of congenital heart disease. However, effective treatments for PAH are rare. This study aimed to investigate the inhibitory effects rapamycin on in carotid artery–jugular vein (CA-JV) shunt rat model as well mechanism underlying these effects. Twenty-four Sprague–Dawley rats were randomized into following 3 groups: control group, CA-JV group and treatment group. Rapamycin (2 mg/kg/day) was administered placebo Haemodynamic...
This study aimed to investigate whether selective antegrade cerebral perfusion or retrograde is a better technique for brain protection in deep hypothermic circulatory arrest by obtaining metabolic evidence from microdialysis.Randomized, animal study.Assisted circulation laboratory.Eighteen piglets of either sex (9.8 ± 3.1 kg).Animals were randomly assigned 40 minutes at 18°C without (deep group, n = 6) with (selective (retrograde 6). Reperfusion was continued 3 hours.Microdialysis (glucose,...
Aortic regurgitation is a severe cardiovascular complication of Behcet's disease, resulting in high mortality rates within the Asian population. Standard surgical interventions have resulted poor results long term. We herein report on modified aortic valve replacement technique coupled with reinforcement wall. During this procedure, Teflon felts and continuous mattress stitches were used to reinforce wall order prevent prosthetic detachment formation an pseudoaneurysm. Postoperative...
Objectives: The alteration of the Toll-like receptor/nuclear factor-kappa B (TLR4/NF-κB) signaling pathway during deep hypothermia circulatory arrest (DHCA) has not yet been defined. aim this study was to explore expression TLR4/NF-κB cytokine in cerebral injury resulting from DHCA as well effect selective antegrade perfusion (SACP) on expression. Methods: Twelve pigs were randomly assigned alone (n = 6) or with SACP at 18°C for 80 min. Serum interleukin (IL)-6 assayed by ELISA. Apoptosis...
Atrial fibrillation (AF) is the most common sustained arrhythmia. DACT2 a novel and important mediator of signaling pathways. The aim this study was to investigate clinical significance functions expression in AF.Immunohistochemistry used detect pattern valvular disease patients. overexpressed HL-1 cells primary atrial fibroblasts. levels potassium channel, L-type calcium current sodium ion channel proteins collagen were detected by real-time polymerase chain reaction (RT-PCR). involved Wnt...