A5035418730- Diabetes Management and Education
- Extracellular vesicles in disease
- Cardiac Valve Diseases and Treatments
- Anesthesia and Sedative Agents
- Diabetes Management and Research
- Airway Management and Intubation Techniques
- Chronic Disease Management Strategies
- Dental Health and Care Utilization
- Lipoproteins and Cardiovascular Health
- Mechanical Circulatory Support Devices
- Diabetes Treatment and Management
- Transplantation: Methods and Outcomes
- Cardiac, Anesthesia and Surgical Outcomes
- Atherosclerosis and Cardiovascular Diseases
- Alzheimer's disease research and treatments
- Epilepsy research and treatment
- Pulmonary Hypertension Research and Treatments
- Dementia and Cognitive Impairment Research
- Atrial Fibrillation Management and Outcomes
- Pharmaceutical Practices and Patient Outcomes
- Cardiovascular Disease and Adiposity
- Oral microbiology and periodontitis research
- Tracheal and airway disorders
- Cardiac Ischemia and Reperfusion
- Magnesium in Health and Disease
Chinese Academy of Medical Sciences & Peking Union Medical College
2006-2024
Sun Yat-sen University
2012-2024
The First Affiliated Hospital, Sun Yat-sen University
2011-2024
Zhejiang Chinese Medical University
2024
SingHealth
2023-2024
National University of Singapore
2010-2023
Capital Medical University
2010
Fudan University
2010
Peking Union Medical College Hospital
2006-2007
Mayo Clinic
2000-2002
<b><i>Objectives:</i></b> To assess the diagnostic specificity of MRI-defined hippocampal atrophy for AD among individuals with a variety pathologically confirmed conditions associated dementia as well changes attributable to typical aging, and measure correlations premortem MRI measurements atrophy, mental status examination performance, pathologic stage AD. <b><i>Methods:</i></b> An unselected series 67 participating in Mayo Alzheimer’s Disease Research Center/Alzheimer’s Patient Registry...
<b><i>Objective:</i></b> To demonstrate structural–functional relationships between MRI-based volumetric measurements of medial temporal lobe structures and cognitive function. <b><i>Background:</i></b> Previous work has documented the ability hippocampus to discriminate age-matched control subjects patients with very mild AD. Relatively less is known about correlation functions. <b><i>Method:</i></b> We evaluated among hippocampal formation, parahippocampal gyrus, amygdala, measures memory,...
To determine if posttraumatic nonconvulsive electrographic seizures result in long-term brain atrophy.Prospective continuous EEG (cEEG) monitoring was done 140 patients with moderate to severe traumatic injury (TBI) and in-depth study of 16 selected using serial volumetric MRI acutely at 6 months after TBI. Fluorodeoxyglucose PET the acute stage 14/16 patients. These data were retrospectively analyzed collection for 7 years.cEEG detected 32/140 (23%) entire cohort. In imaging subgroup,...
Despite the well-recognized importance of caries risk assessment, practical models remain to be established. This study was designed develop biopsychosocial for assessment in various settings. With a questionnaire, an oral examination, and biological (salivary, microbiological, plaque pH) tests, prospective conducted among 1782 children aged 3-6 years, with 1576 (88.4%) participants followed 12 months. Multiple factors, indicators, protective factors were identified. Various constructed by...
Therapeutic angiogenesis remains unsuccessful in coronary artery disease. It is known that plasma endothelium-derived microparticles (EMPs) are increased disease and hypercholesterolemia can inhibit angiogenesis. We evaluated the relationship between EMPs impairment of isolated from human umbilical vein endothelial cells were injected into low-density lipoprotein receptor-null (LDLr(-/-)) mice fed a Western diet for 2 wk C57BL6 6 h or directly added to tissue culture media. Hearts sectioned...
Policymakers' understanding of and ability to reduce health disparities are pivotal for promotion worldwide. This study aimed verify the behavioral pathways leading oral disparities. Oral examinations were conducted 1782 randomly selected preschoolers (3-6 yrs), 1576 (88.4%) participants followed up after 12 months. Parents surveyed on their knowledge (K), attitude (A), practices (P) regarding children's homecare (infant feeding, diet, hygiene) dental attendance. Structural equation modeling...
Objective— Myocardial injury during cardiac surgery is a major cause of perioperative morbidity and mortality. We determined whether statin therapy cardioprotective in patients undergoing noncoronary artery the potential mechanisms. Methods Results— One hundred fifty-one were randomly assigned to either group (n=77) or control (n=74). Simvastatin (20 mg) was administered preoperatively postoperatively. Plasma analyzed for troponin T, isoenzyme creatine kinase, C-reaction protein,...
Normal high-density lipoprotein (nHDL) in normal, healthy subjects is able to promote angiogenesis, but the mechanism remains incompletely understood. HDL from patients with coronary artery disease may undergo a variety of oxidative modifications, rendering it dysfunctional; whether angiogenic effect mitigated by such dysfunctional (dHDL) unknown. We hypothesized that dHDL compromises angiogenesis. The effects nHDL and were assessed using endothelial cell culture, sprouts cardiac tissue...
True fractional Ca absorption (TFCA) was compared in children with different habitual intakes using a double-label stable-isotope technique. Chinese aged 7 years from Hongkong (n22) and Jiangmen (n12) participated the study. An oral administration of 8 mg 44Ca 100 g chocolate milk given shortly after an intravenous injection 0.75 42Ca. isotopic ratios were determined urine samples collected 24 h later thermal-ionization mass spectrometry. There no significant difference TFCA between (P =...
We investigated the relationship between preoperative quantitative magnetic resonance imaging (MRI) T2 relaxometry and volumetry of hippocampi pre- postoperative verbal memory in temporal lobectomy patients who had nonlesional lobe epilepsy.Pre- data based on Logical Memory (LM) subtest Wechsler Scale-Revised (WMS-R) 30-min delayed recall trial Rey Auditory Verbal Learning Test (AVLT) were obtained from 26 left 15 right patients. Coronal MRI maps generated for these 41 as well 61 control...
An apolipoprotein A-I mimetic peptide, D-4F, has been shown to improve vasodilation and inhibit atherosclerosis in hypercholesterolemic low-density lipoprotein receptor-null (LDLr(-/-)) mice. To study the metabolic variations of D-4F ininhibiting atherosclerosis, metabonomics, a novel system biological strategy investigate pathogenesis, was developed. Female LDLr(-/-) mice were fed Western diet injected with or without intraperitoneally. Atherosclerotic lesion formation measured, whereas...
Abstract: Simvastatin treatment is cardioprotective in patients undergoing noncoronary artery cardiac surgery. However, the mechanisms by which simvastatin protects myocardium under these conditions are not fully understood. Seventy surgery, 35 from a group and control group, were enrolled our clinical study. (20 mg/d) was administered preoperatively for 5–7 days. Myocardial tissue biopsies taken before after Apoptosis detected TUNEL staining. The expressions of Bcl-2 Bak myocardial...
Summary The circulatory responses to fibreoptic intubation under general anaesthesia were studied in 60 adult female patients who randomly assigned receive either the oral or nasal route for insertion. Non‐invasive blood pressure and heart rate recorded before induction (baseline values), immediately after (post‐induction at every minute a further 5 min. product of systolic (rate product) time point was also calculated. results showed that both orotracheal nasotracheal resulted significant...
A double-blind controlled Ca supplementation trial was conducted for 6 months in thirty-four 7-year-old Chinese children from Hongkong and Jiangmen, China. The were randomly allocated to the study group ( n 17) or control 17), a CaCO 3 tablet (300 mg Ca) placebo taken daily. True fractional absorption (TFCA) evaluated before after using stable isotopes: 8 44 mixed 100 g chocolate milk given an intravenous injection of 0·75 42 Ca. There no significant difference baseline TFCA between (60·6...
The available data provide inconsistent results on the efficacy of small-dose remifentanil attenuating cardiovascular response to intubation in children. Therefore, this randomized double-blind study was designed assess ability different small doses children, with aim determining optimal dose for purpose.One hundred and twenty-four children aged 3-9 yr were one four groups receive following a manner: normal saline (Group 1), 0.75 microg kg(-1) 2), 1 3) 1.25 4). Non-invasive blood pressure...