A5024300922- Asthma and respiratory diseases
- Neonatal Respiratory Health Research
- Immune Response and Inflammation
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Sinusitis and nasal conditions
- Pulmonary Hypertension Research and Treatments
- COVID-19 Clinical Research Studies
- Pediatric health and respiratory diseases
- SARS-CoV-2 and COVID-19 Research
- Respiratory viral infections research
- Influenza Virus Research Studies
- interferon and immune responses
- Neuroscience of respiration and sleep
- Nitric Oxide and Endothelin Effects
- Inflammatory mediators and NSAID effects
- High Altitude and Hypoxia
- Immunotherapy and Immune Responses
- Biopolymer Synthesis and Applications
- RNA Interference and Gene Delivery
- Long-Term Effects of COVID-19
- Anesthesia and Neurotoxicity Research
- Inhalation and Respiratory Drug Delivery
- Advanced biosensing and bioanalysis techniques
- TGF-β signaling in diseases
- Tracheal and airway disorders
Guangzhou Medical University
2010-2025
Capital Medical University
2024
Chinese Institute for Brain Research
2024
First Hospital of Shanxi Medical University
2024
Shanxi Medical University
2024
State Key Laboratory of Respiratory Disease
2009-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Peking Union Medical College Hospital
2023
Shanghai Electric (China)
2023
Changhai Hospital
2023
Background. Previous studies have shown that common human coronavirus might be neurotropic, although it was first isolated as a pathogen of the respiratory tract. We noticed few patients with severe acute syndrome (SARS) experienced central nervous symptoms during course illness. In present study, we SARS strain from brain tissue specimen obtained patient significant symptoms.
There is currently no optimal treatment or effective drug for severe acute respiratory syndrome (SARS), because the immunopathologic mechanism poorly understood.To explore immune underlying pathogenesis of SARS, we studied expression profile cytokines/chemokines in blood and immunopathology lung lymphoid tissues.Fourteen 23 patients with SARS were dynamically screened, using a bead-based multiassay system. Reverse transcription-polymerase chain reaction was performed to amplify mRNA....
Epithelial to mesenchymal transition (EMT) in alveolar epithelial cells (AECs) has been widely observed patients suffering interstitial pulmonary fibrosis. In vitro studies have also demonstrated that AECs could convert into myofibroblasts following exposure TGF-β1. this study, we examined whether EMT occurs bleomycin (BLM) induced fibrosis, and the involvement of bronchial (BECs) EMT. Using an α-smooth muscle actin-Cre transgenic mouse (α-SMA-Cre/R26R) strain, labelled vivo. We performed a...
Abstract The novel avian origin influenza A (H7N9) virus has caused severe diseases in humans eastern China since the spring of 2013. Fatal outcomes H7N9 infections are often attributed to pneumonia and acute respiratory distress syndrome (ARDS). There is urgent need discover biomarkers predicting progression disease fatal outcome potentially lethal flu infections, based on sound statistical analysis. We discovered that 34 48 cytokines chemokines examined this study were significantly...
ABSTRACT Clear cell renal carcinoma (ccRCC) is a common malignant cancer with high mortality rate. Activating transcription factor 2 (ATF2) and pleckstrin homology domain containing O1 (PLEKHO1) were reported to participate in numerous cancers. However, their roles the detailed mechanisms ccRCC development remain largely unknown. RT‐qPCR western blot used measure levels of PLEKHO1, ATF2, nuclear undecaprenyl pyrophosphate synthase 1 (NUS1). Cell proliferation, apoptosis, invasion, migration...
Abstract Chronic rhinosinusitis with nasal polyps (CRSwNP) is a highly heterogeneous disease different host defence responses. However, whether periostin and vascular endothelial growth factor (VEGF) are similarly impaired in patients eosinophilic CRSwNP (ENP) those non-eosinophilic (nENP) remains unclear. We sought to evaluate the expression possible modulation of VEGF, regulated on activation normal T expressed secreted (RANTES) eotaxin-2 polyp tissues from 30 ENP 36 nENP middle turbinate...
Abstract Background Interstitial pneumonia in connective tissue diseases (CTD-IP) featuring inflammation and fibrosis is a leading cause of death CTD-IP patients. The related autoimmune lung injury disturbed self-healing process make conventional anti-inflammatory drugs ineffective. Equipped with unique immunoregulatory regenerative properties, mesenchymal stem cells (MSCs) may represent promising therapeutic agent CTD-IP. In this study, we aim to define the immunopathology involved...
Abstract: BACKGROUND: Hemorrhagic shock (HS) causes severe organ damage, worsened by high-altitude conditions with lower oxygen and temperatures. Existing research lacks specific insights on brain heart damage under these conditions. This study hypothesizes that cold (HAC) environments exacerbate HS-induced in the heart, aiming to improve treatment strategies. MATERIALS AND METHODS: Twenty-four male Sprague-Dawley (SD) rats (200–250 g of weight) were randomly assigned into sham, HS + normal,...
Abstract Objective This study aims to investigate the clinical and pathological characteristics, treatment approaches, prognosis of gallbladder neuroendocrine carcinoma (GB-NEC). Methods Retrospective analysis was conducted on data 37 patients with GB-NEC admitted Shanxi Cancer Hospital from January 2010 June 2023. The included an examination their general information, regimens, overall prognosis. Results Twelve cases, either due distant metastasis or other reasons, did not undergo surgical...
Summary Background Exposure to allergens or air pollutants often leads asthma exacerbations associated with aggravation of airway inflammation. Although, repeated allergen challenge induces chronic allergic inflammation (CAAI) and remodelling, yet, the effects brief exposure such as SO 2 on development CAAI remodelling remain be clarified. Objective The aim experiment was investigate acute neutrophilic induced by subepithelial fibrosis (SEF) in a murine model asthma. Methods Acute 50 p.p.m....
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a complex inflammatory disease of the and paranasal sinus mucosa. The associated mitochondrial dysfunction, structural changes in mitochondria, reactive oxygen species (ROS) generation. This study investigated whether there are functional morphological mitochondria epithelial cells (NPs) Staphylococcus aureus enterotoxin B (SEB)-stimulated cells.In all, 30 patients CRSwNP 15 healthy subjects were enrolled. Mitochondrial ROS (mtROS)...
Highly pathogenic avian influenza viruses (HPAIVs) cause severe disease in humans. There are no effective vaccines or antiviral therapies currently available to control fatal outbreaks due part the lack of understanding virus-mediated immunopathology. In our study, we used hemagglutinin (HA) H5N1 virus investigate related signaling pathways and their relationship dysregulated innate immune reaction. We found HA triggered an abnormal signalling pulmonary epithelial cells, through unusual...
The host tolerance mechanisms to avian influenza virus (H5N1) infection that limit tissue injury remain unknown. Emerging evidence indicates cystic fibrosis transmembrane conductance regulator (CFTR), a cAMP-dependent Cl− channel, modulates airway inflammation. Janus tyrosine kinase (JAK) 3, JAK family member plays central role in inflammatory responses, prominently contributes the dysregulated innate immune response upon H5N1 attachment; therefore, this study aims elucidate whether JAK3...
Summary Background There is evidence that tumour necrosis factor alpha (TNFα) may be an important mediator in initiating asthmatic airway inflammation. It has been proposed endothelin‐1 (ET‐1) involved bronchoconstriction and remodelling asthma. not known, however, if there any interaction between TNFα ET perpetuating inflammation Objective The present study aimed to determine the activities of ET‐1 ovalbumin‐sensitized guinea pigs their roles development Method Twelve were sensitized by...
Objective: The study was to evaluate neurotoxicity caused by antibiotics in dialysis patients, including incidence, clinical features, treatments and prognosis. Methods: In this retrospective study, we reviewed the medical records of 1066 patients (254 peritoneal [PD] cases 812 hemodialysis [HD] cases) who also received intravenous our hospital during July 2006 – April 2012. Naranjo scale used for estimating probability an adverse drug reaction. Results: incidence antibiotic-induced 5.66%...
The Toll-like receptor 9 (TLR9) signaling pathway is involved in the pathogenesis of chronic rhinosinusitis (CRS) with nasal polyposis. aim this study was to assess therapeutic potential TLR9 inhibitor chloroquine CRS mice.The expression type I interferons (IFNs) human tissues evaluated using quantitative polymerase chain reaction (qPCR), western blotting, and immunofluorescence. Mice were divided into 4 treatment groups: control, polyp (NP), (NP + Chlq), dexamethasone Dexa) groups. effects...
Abstract Background In allergic asthma, Th2 lymphocytes are believed to play important roles in orchestrating airway eosinophilia and inflammation. Resetting the Th1/Th2 imbalance may have a therapeutic role asthma. The mycobacterium tuberculosis 30-kilodalton major secretory protein (antigen 85B, Ag85B) can protect animals from M. infection by inducing Th1-dominant response. Methods this study, Ag85B gene was cloned into pMG plasmids yield pMG-Ag85B plasmid. expression of murine bronchial...
OBJECTIVE Acute respiratory distress syndrome (ARDS) is greatly threatening human health with high morbidity and mortality. The pathogenesis of ARDS closely related to the inflammatory response in patients. micro-ribonucleic acid (miR)-155/nuclear factor-κB (NF-κB) signaling pathway crucial regulating expression inflammation-related genes. Therefore, influences miR-155/NF-κB on factors neonatal pigs were explored this study. MATERIALS AND METHODS model was established first. levels miR-155,...