A5049398736- Laser-Plasma Interactions and Diagnostics
- Laser-induced spectroscopy and plasma
- Laser-Matter Interactions and Applications
- Lung Cancer Research Studies
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Gamma-ray bursts and supernovae
- Medical Imaging Techniques and Applications
- Planetary Science and Exploration
- Thyroid Cancer Diagnosis and Treatment
- Cancer, Stress, Anesthesia, and Immune Response
- Radiomics and Machine Learning in Medical Imaging
- Neuroscience and Neuropharmacology Research
- Streptococcal Infections and Treatments
- T-cell and B-cell Immunology
- Traditional Chinese Medicine Analysis
- Infective Endocarditis Diagnosis and Management
- Cardiac Arrhythmias and Treatments
- Medical Imaging and Pathology Studies
- Acupuncture Treatment Research Studies
- Neuroendocrine Tumor Research Advances
- High-pressure geophysics and materials
- Gestational Trophoblastic Disease Studies
- Advanced X-ray Imaging Techniques
- Effects of Radiation Exposure
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2025
Shanxi Medical University
2020-2024
First Hospital of Shanxi Medical University
2020-2024
Shanghai Institute of Optics and Fine Mechanics
2022-2023
Chinese Academy of Sciences
2022-2023
Zhejiang Cancer Hospital
2022
University of Chinese Academy of Sciences
2022
Hospital of Hebei Province
2015
Huazhong University of Science and Technology
2009
High-energy, high-flux collimated proton beams with high repetition rates are critical for applications such as therapy, radiography, high-energy-density matter generation, and compact particle accelerators. However, achieving beam collimation has typically relied on complex expensive target fabrication or precise control of auxiliary laser pulses, which poses significant limitations high-repetition applications. Here, we demonstrate an all-optical method acceleration using a single...
Graves' disease (GD) is one of the most common autoimmune conditions, but mechanisms underlying associated induction autoimmunity are not known. We explored role peripheral lymphocyte subpopulations in pathogenesis.In total, 32 patients and 40 age- sex-matched healthy controls were recruited this study. Peripheral levels T, B, NK, CD4+ CD8+ Th1, Th2, Th17, Treg cells measured using flow cytometry. For all patients, we compared between GD controls. Changes patient subsets before after...
Abstract Objective This study aims to investigate the clinical and pathological characteristics, treatment approaches, prognosis of gallbladder neuroendocrine carcinoma (GB-NEC). Methods Retrospective analysis was conducted on data 37 patients with GB-NEC admitted Shanxi Cancer Hospital from January 2010 June 2023. The included an examination their general information, regimens, overall prognosis. Results Twelve cases, either due distant metastasis or other reasons, did not undergo surgical...
In this study, an extreme ultraviolet (EUV) conversion efficiency (CE) of 6.9% was obtained in simulation by controlling the delay between a picosecond pre-pulse and main-pulse with wavelength 2 μm; value is about 7.5% higher than ns scheme EUV emission produced μm laser-driven tin-droplet target. simulation, tin droplet expanded into hollow spherical structures after irradiation laser. Notably, compared nanosecond pre-pulse, case, density plasma lower, expansion range wider for same delay....
To explore the role of protein kinase A (PKA) in regulating tau phosphorylation and spatial memory, we injected forskolin, an activator PKA, at different concentrations into rat brains. We found that forskolin up to 80 μM enh
Collimation control of energetic plasma beams is crucial in the laser–plasma field. In this paper, we report on a self-collimated acceleration scheme for beam using an ultra-intense Laguerre–Gaussian (LG) laser irradiating solid target. Three-dimensional (3D) particle-in-cell simulations show that with high current density stably formed by radiation pressure hollow LG laser. The initial interaction target can be approximately researched deformable mirror model. Under effect ponderomotive...
Abstract In this study, three-dimensional particle-in-cell (PIC) simulations were conducted to evaluate a collimated proton beam accelerated by an intense Laguerre–Gaussian (LG) laser with different pulse durations. The flux and energy of the could be simultaneously enhanced selecting optimal duration. This phenomenon can primarily attributed correlation between LG driven self-generated magnetic field duration, enables collimation protons during their interaction transport. results obtained...
An all-optical approach to edge-enhanced proton radiography is realized by using a relativistic vortex laser irradiating on nanometer-thick foil. In the proof-of-principle experiments, hollow beam was successfully produced transparent target normal electric field sheath in break-out after-burner acceleration mechanism, superintense Laguerre–Gauss with highest intensity of exceeded 1020 W/cm2. insect imaged beam; leg structures edge were clearly captured. By contrast, dot source Gaussian...
A micrometer-scale “plasma lens” self-constructed by the prepulse and main pulse of Laguerre–Gaussian (LG) laser is realized to enhance collimation acceleration proton beams in a target normal sheath field mechanism. Hydrodynamic FLASH particle-in-cell simulations are carried out find that collimated source with beam divergence ∼2.7° generated LG laser, which smaller than case driven traditional Gaussian laser. It demonstrates curved on plays an important role collimation. Such approach...
Abstract Background Advanced non-squamous non-small cell lung cancer (NS-NSCLC) patients without driver gene mutations are usually treated with immune checkpoint inhibitors (ICIs) plus pemetrexed as maintenance therapy after first-line ICIs 4–6 cycles of pemetrexed/platinum. Some in the real world receive monotherapy therapy. No clinical study has compared efficacy and safety or Methods We performed a retrospective analyzing data NS-NSCLC who were diagnosed Zhejiang Cancer Hospital from...
Differentiated thyroid cancer is the most frequently diagnosed endocrine tumor. While differentiated cancers often respond to initial treatment, little known about differences in circulating immune cells amongst patients who differently. A prospective study of 39 with was conducted. Serum thyroglobulin levels and immunological functions were tested before after radioactive iodine treatment (RAIT). Efficacy assessments performed 6 12 months treatment. Most showed an excellent response Before...
Anaplastic lymphoma kinase (ALK) fusion is an important oncogenic driver in non-small cell lung cancer (NSCLC). Reports on the intergenic region (IGR) as ALK partner are rare. Here, we report case of a patient with advanced NSCLC harboring human immunodeficiency virus type I enhancer binding protein 1 (HIVEP1)-ALK that responded effectively to alectinib.A 60-year-old non-smoking male was referred 3-month history productive cough secondary adenocarcinoma metastatic mediastinal lymph nodes,...
A novel flying cascaded acceleration mechanism is proposed to generate energetic proton beams with multi-peak energy spectra using a circularly polarized (CP) Laguerre–Gaussian (LG) laser pulse in three-dimensional particle-in-cell simulations. Simulations show that the protons are initially accelerated and compressed into beam center via radiation pressure of CP LG (σz = −1) pulse. Then, they tailored by dipolar electric fields this laser, resulting spectrum. Each shaped peak exhibits...
This study entailed the development of a high-gradient modulation microbunching for traditional radiation frequency accelerators using minimized system driven by relativistic Laguerre–Gaussian (LG) laser in three-dimensional particle-in-cell (PIC) simulations. It was observed that LG could compress transverse dimension beam to within 0.7 µm radius (divergence≈4.3 mrad), which is considerably lower than case tuned Gaussian laser. In addition, electron be efficiently modulated high degree...
Objective To evaluate the differential diagnosis value of enhanced multi-slice spiral CT (MSCT) scan on adrenal adenoma and metastases in patients with malignant tumor. Methods Thirty-nine tumor complicated nodules were chosen, all underwent MSCT plain scan. Features adenomas analyzed. Results Forty-nine gland found 39 patients, 35 metastasis 25 patients. They shown quasi-circular, oval or irregular shaped nodules. The average diameter was (2.6±0.7)cm. Part them uneven density,...
Objective To investigate the effect of Shenqi-Tongmai decoction in Stable Angina pectoris Patients with Qi-deficiency-blood-stasis syndrome and influence on serum associated adhesion factors. Methods A total 110 patients stable angina treated department cardiology traditional Chinese medicine hospital Xinle city from Feb. 2015 to 2017 were divided into 2 groups according number random table method, 55 each group. All given standardized treatment western medicine, group aditionally...
The effects of total thyroidectomy or radioactive iodine therapy on immune activation and suppression the tumor microenvironment remain unknown. We aimed to investigate these treatments function in patients with differentiated thyroid carcinoma (DTC). Our cohort included 45 DTC treated (RAIT). Immune tests were performed by flow cytometry at 0, 30, 90 days post-RAIT. Both percentage absolute number circulating regulatory T cells significantly lower postoperative compared healthy controls....