A5101995858- Asthma and respiratory diseases
- Neuroscience of respiration and sleep
- Respiratory Support and Mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Sulfur Compounds in Biology
- Reproductive System and Pregnancy
- Orthopaedic implants and arthroplasty
- Respiratory and Cough-Related Research
- Neonatal Respiratory Health Research
- Estrogen and related hormone effects
- Obstructive Sleep Apnea Research
- Total Knee Arthroplasty Outcomes
- Reproductive Biology and Fertility
- Protein Interaction Studies and Fluorescence Analysis
- Endometriosis Research and Treatment
- Pelvic floor disorders treatments
- Neuropeptides and Animal Physiology
- Heme Oxygenase-1 and Carbon Monoxide
- Radiomics and Machine Learning in Medical Imaging
- Immune Cell Function and Interaction
- Alzheimer's disease research and treatments
- Neonatal Health and Biochemistry
- Cystic Fibrosis Research Advances
- Infant Health and Development
- Neuroendocrine regulation and behavior
Hangzhou First People's Hospital
2024
Westlake University
2024
Sichuan University
2021-2023
First Affiliated Hospital of Guangzhou Medical University
2017-2022
Sun Yat-sen University
2014-2022
State Key Laboratory of Respiratory Disease
2017-2022
Guangzhou Medical University
2017-2022
University Town of Shenzhen
2022
West China Hospital of Sichuan University
2021
Nanjing Medical University
2017
Abstract Background Neuroinflammation, which ultimately leads to neuronal loss, is considered play a crucial role in numerous neurodegenerative diseases. The neuroinflammatory process characterized by the activation of glial cells such as microglia. Endoplasmic reticulum (ER) stress commonly associated with impairments function and cognition, but its relationship neurodegeneration still controversial. Recently, it was confirmed that nonharmful levels ER protected against experimental...
Postoperative cognitive dysfunction (POCD) is a common postoperative complication in elderly patients, and neuroinflammation key hallmark. Recent studies suggest that the NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome-mediated astrocytes pyroptosis involved regulation of many neurocognitive diseases, while its role POCD remains obscure. Carnosine natural endogenous dipeptide with anti-inflammatory neuroprotective effects. To explore effect carnosine on mechanism, we...
As a novel gasotransmitter, hydrogen sulfide (H2S) elicits various physiological actions including smooth muscle relaxation and promotion of transepithelial ion transport. However, the pro-secretory function H2S in male reproductive system remains largely unclear. The aim this study is to elucidate possible roles modulating rat epididymal intraluminal ionic microenvironment essential for sperm storage. results revealed that endogenous H2S-generating enzymes cystathionine β-synthetase (CBS)...
Sputum symptoms are commonly seen in the elderly. This study aimed to identify an efficacious expectorant treatment stratagem through evaluating secretion-promoting activation and cystic fibrosis transmembrane conductance regulator (CFTR) expression of bioactive herbal monomer naringenin.Vectorial Cl- transport was determined by measuring short-circuit current (ISC) rat airway epithelium. cAMP content measured ELISA primary cultured epithelial cells Calu-3 cells. CFTR qPCR.Addition...
Naringin and its aglycone, naringenin, occur naturally in our regular diet traditional Chinese medicines. This study aimed to detect an effective therapeutic approach for cough variant asthma (CVA) through evaluating the relaxant effect of these two bioactive herbal monomers as antitussive antiasthmatic on rat tracheal smooth muscle. The was determined by measuring muscular tension with a mechanical recording system rings. Cytosolic Ca2+ concentration measured using confocal imaging primary...
Sodium tanshinone IIA sulfonate (STS) is a derivate of IIA, lipophilic compound in Salvia miltiorrhiza. This study aimed to investigate the effect STS on ion transport mouse tracheal epithelium and mechanisms underlying it. Short-circuit current (Isc) was measured evaluate transepithelial transport. Intracellular Ca2+ imaging performed observe intracellular concentration ([Ca2+]i) changes induced by primary cultured epithelial cells. Results showed that apical application at trachea elicited...
Abstract G protein-coupled estrogen receptor (GPER), a seven-transmembrane receptor, mediates the rapid pre-genomic signaling actions of and derivatives thereof. The expression GPER is extensive in mammal male reproductive system. However, functional role mouse sperm has not yet been well recognized. This study revealed that was expressed at acrosome mid-flagellum sperm. endogenous ligand 17β-estradiol selective agonist G1 increased intracellular Ca2+ concentration ([Ca2+]i) sperm, which...
Airway remodeling is an important feature of chronic obstructive pulmonary disease (COPD) that associated with severity and irreversible airflow limitation. An extensive alteration the extracellular matrix (ECM) surrounding airway smooth muscle (ASM) bundle one pathological manifestations remodeling, which contributes to decline in lung function. Tiotropium, a long-acting inhaled muscarinic receptor antagonist, has been confirmed play role preventing including ECM deposition beyond...
Abstract High-pressure non-invasive positive pressure ventilation (NPPV) is a new strategy targeted at maximally reducing arterial carbon dioxide. However, high inspiratory airway (IPAP) might cause respiratory adverse events likely to diminish the benefit of NPPV. In setting ventilatory support, monitoring NPPV efficacy and resolving problems promptly are critical. This study assessed treatment effect low-pressure in chronic hypercapnic COPD using home ventilator with built-in software....
The neurohypophyseal hormone oxytocin (OT) plays critical roles in lactation and parturition, while its function male reproduction system is largely unknown. This study aims to investigate the effect of OT on regulating transepithelial ion transport rat cauda epididymal epithelium. With use RT-PCR, Western blot, immunohistochemical analysis, we found that receptor (OTR) was expressed localized at basal membrane short-circuit current ( I sc ) measurement showed basolateral application primary...
Purpose: Patients with advanced-stage COPD often experience severe hypoxemia. Treatment long-term oxygen therapy (LTOT) may relieve patients’ symptoms and increase survival. As is incurable, improving health-related quality of life important. The Chinese version the Severe Respiratory Insufficiency Questionnaire (SRI) valid for patients hypercapnic undergoing noninvasive positive airway pressure ventilation at home. However, reliability validity SRI LTOT have not been investigated. methods:...
Abstract The vagina provides a characteristic low‐Na + and low‐pH fluid microenvironment that is considered generally protective. Previous studies have shown various types of epithelial cells harbor the capacity intracellular pH (pHi) regulation. However, it remains elusive whether vaginal epithelium could actively regulate pHi by transporting acid–base ions. In this study, we verified after transient exposure to NH 4 Cl, values rapidly recover from acidification via Na ‐H exchanger (NHE),...
Introduction Obesity hypoventilation syndrome (OHS) is a major respiratory complication caused by severe obesity, being associated with significant morbidity, negative impacts on quality of life and reduced survival if not treated appropriately. Positive airway pressure therapy the first-line treatment for OHS although optimal modality remains unclear. The goal this study to identify efficacy home bilevel positive comparison continuous determine best strategy patients OHS. Methods analysis...