A5021761453- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neonatal Respiratory Health Research
- Air Quality and Health Impacts
- Adenosine and Purinergic Signaling
- Neuroscience of respiration and sleep
- Osteoarthritis Treatment and Mechanisms
- Hedgehog Signaling Pathway Studies
- Plant Molecular Biology Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Health, Environment, Cognitive Aging
- T-cell and Retrovirus Studies
- Thermal Regulation in Medicine
- Immune Response and Inflammation
- Climate Change and Health Impacts
- Intensive Care Unit Cognitive Disorders
- Chemokine receptors and signaling
- Polysaccharides and Plant Cell Walls
- Sulfur Compounds in Biology
- Animal Disease Management and Epidemiology
- Plant Reproductive Biology
- COVID-19 Clinical Research Studies
- Pediatric health and respiratory diseases
- Orthopaedic implants and arthroplasty
- Hip disorders and treatments
Beijing Sport University
2025
Sun Yat-sen University
2014-2025
The First Affiliated Hospital, Sun Yat-sen University
2023-2025
Hospital of Hebei Province
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Anhui Agricultural University
2024
Peking University
2020-2024
Peking University Third Hospital
2024
Shanxi University
2022-2024
Harbin Medical University
2024
Abstract Background Healthcare workers are often exposed to stressful working conditions at work which affect their quality of life. The study investigated the relationship between psychosocial risk factors, stress, burnout, and life among primary healthcare in general medical practice Qingyuan Chaozhou cities Guangdong province. Method cross-sectional was conducted 108 health facilities including 36 community centers (CHCs) across two developing A total 873 completed questionnaires. Quality...
TIR1 and its homologues act as auxin receptors play a crucial role in auxin-mediated plant development. While the functions of receptor genes have been widely studied Arabidopsis thaliana, there has no report on consequences overexpression plants that regulate fruit Here putative tomato gene, homologous to AtTIR1, is reported. This designated Solanum lycopersicum (SlTIR1), was found be expressed all parts floral buds flowers at anthesis stages. From bud anthesis, SlTIR1 expression increases...
Abstract Observational studies have reported an association of handgrip strength with risk cardiovascular disease. However, residual confounding and reverse causation may influenced these findings. A Mendelian randomization (MR) study was conducted to examine whether is causally associated Two single nucleotide polymorphisms (SNPs), rs3121278 rs752045 , were used as the genetic instruments for handgrip. The effect each SNP on coronary artery disease/myocardial infarction (CAD/MI) weighted by...
Abstract Severe viral pneumonia caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is characterized a hyperinflammatory state typified elevated circulating pro-inflammatory cytokines, frequently leading to potentially lethal vascular complications including thromboembolism, disseminated intracellular coagulopathy and vasculitis. Though endothelial infection subsequent damage have been described in patients with fatal COVID-19, mechanism which this occurs remains...
Excessive tachycardia is associated with impaired hemodynamics and worse outcome in critically ill patients. Previous studies suggested beneficial effect of β-blockers administration ICU patients, including those septic shock. However, comparisons settings are lacking. Our study aims to compare Landiolol Esmolol regarding heart rate control hemodynamic variables general This retrospective, observational was conducted a 56-bed at university hospital. A propensity score matching (PSM) employed...
<title>Abstract</title> <bold>Purpose</bold> The impact of femoroacetabular impingement syndrome (FAIS) on gait has been reported; however, no studies have documented the effects Borderline Developmental Dysplasia Hip (BDDH) combined with FAIS gait. This study aimed to evaluate kinematic and kinetic abnormalities lower extremities in patients BDDH during level walking. <bold>Methods</bold> A total 42 participants were included, consisting 14 + BDDH, isolated healthy controls. Full-cycle data...
Career success is crucial for both individuals and organizations. Even though career considered an individual result, it depends on the organization's can contribute to its success. This study uses proactive personality needs-supplies fit as independent variables explore potential relationship between of pediatric healthcare workers. The dataset used in was formed through convenience sampling at Children's Hospital Hebei Province September October 2023, using Wenjuanxing online platform,...
Cardiac output (CO) monitoring is essential for diagnosing and managing critically ill patients. Recently, a non-invasive haemodynamic technique, electrical cardiometry (EC), has gathered increasing interest among ICU physicians. This study aimed to explore the accuracy of CO estimated by EC (COEC) compared determined transpulmonary thermodilution (COTPTD) evaluate ability COEC track COTPTD changes (ΔCOTPTD). prospective, observational, single-center was conducted from April 2021 2023,...
Aptamers, which are short, single‐stranded DNA or RNA, capable of binding to a wide array targets with exceptional selectivity. Those high affinity for theophylline have the potential serve as biosensors, crucial tracking levels in treatment respiratory conditions. Despite extensive structural characterization RNA aptamer, counterpart’s ligand‐recognition mechanism has remained unclear. Here, we elucidate aptamer’s ligand‐binding through high‐resolution crystal structures its complexes...
Abstract Objectives This study aims to assess the predictive value of preoperative parameters on recovery outcomes in patients with myelopathy caused by cervical ossification posterior longitudinal ligament (COPLL) undergoing laminoplasty (LAMP). Methods A retrospective analysis was performed COPLL who underwent LAMP between 2017 and 2020. Preoperative variables, including basic epidemiological characteristics, comorbidities, functional scores, K-line-related parameters, Torg-Pavlov ratio,...
Abstract Transition metals are not only residual impurities in β-Ga 2 O 3 single crystals, but also hold significant potential doped substrates and epitaxial films for power electronics, optoelectronics, memory devices. Current research primarily focuses on iron titanium, with limited comprehensive studies manganese. Using first-principles calculations hybrid functionals, we investigated the formation energy, thermodynamic transition levels, nonradiative capture coefficients of Mn dopant ....
Rationale: Genetic association studies have identified rs2076295 in with idiopathic pulmonary fibrosis (IPF). We hypothesized that is the functional variant regulating DSP (desmoplakin) expression human bronchial epithelial cells, and regulates extracellular matrix–related gene cell migration, which relevant to IPF development.Objectives: To determine whether function of airway cells.Methods: Using CRISPR (clustered regularly interspaced short palindromic repeat)/Cas9 editing (including...
Although HHIP locus has been consistently associated with the susceptibility to COPD including airway remodeling and emphysema in genome-wide association studies, molecular mechanism underlying this genetic remains incompletely understood. By utilizing Hhip
Myoglobin is an important biomarker for monitoring critically ill patients. However, the relationship between its dynamic changes and prognosis remains unclear. We retrospectively enrolled 11,218 patients from a general surgical intensive care unit (ICU) of tertiary hospital June 2016 May 2020. Patients with acute cardiovascular events, cardiac major vascular surgeries, rhabdomyolysis were excluded. To investigate early myoglobin distribution, stratified according to highest level within 48...
Objectives This study aims to investigate the diagnostic value of heparin-binding protein (HBP) in sepsis and develop a model incorporating HBP with key biomarkers disease-related scores for rapid, accurate diagnosis intensive care unit (ICU). Design Clinical retrospective cross-sectional study. Setting A comprehensive teaching tertiary hospital China. Participants Adult patients (aged ≥18 years) who underwent testing or whose blood samples were collected when admitted ICU. Main outcome...
P2Y receptors are expressed in virtually all epithelia and responsible for the control of fluid electrolyte transport. In asthmatic inflammation, bronchial damaged by eosinophil-derived, highly toxic cationic proteins, such as major basic protein (MBP). Consequently, extracellular nucleotides released into space from airway epithelial cells, act an autocrine or paracrine fashion to regulate immune functions. Our data show damage human cell line, 16HBE14o-, poly-L-arginine-induced UDP release...
Abnormalities in purine availability or purinergic receptor density are commonly seen patients with lower urinary tract symptoms (LUTS), but the underlying mechanisms relating altered function to LUTS unknown. Here we provide extensive evidence for reciprocal interplay of multiple receptors responding ATP, ADP (adenosine diphosphate), and adenosine, agonists that regulate bladder significantly. stimulated P2Y12 receptors, causing smooth muscle (BSM) contraction, whereas adenosine signaling...
Murine studies have linked TGF-β signaling to emphysema, and human genome-wide association (GWAS) of lung function COPD identified associated regions near genes in the superfamily. However, functional regulatory mechanisms at these loci not been identified. We performed largest GWAS emphysema patterns date, identifying 10 including an peak spanning a 200 kb region downstream from
(1) to investigate the consecutive changes in hip muscle volume patients with femoroacetabular impingement syndrome (FAIS) during initial postoperative period, and (2) determine potential effect of early on clinical outcomes. Data between March 2021 2022 was reviewed. Patients diagnosed FAIS based symptoms radiographic findings, undergoing arthroscopic treatment were included. Exclusion criteria incomplete MRI data, prior history surgery, concomitant conditions including osteoarthritis a...