A5101544175- Diet and metabolism studies
- Liver Disease Diagnosis and Treatment
- Genetics, Aging, and Longevity in Model Organisms
- Pancreatic function and diabetes
- Antioxidants, Aging, Portulaca oleracea
- Metabolism, Diabetes, and Cancer
- Pancreatitis Pathology and Treatment
- Adipose Tissue and Metabolism
- Kidney Stones and Urolithiasis Treatments
- Drug Transport and Resistance Mechanisms
- interferon and immune responses
- Forensic and Genetic Research
- Autophagy in Disease and Therapy
- Streptococcal Infections and Treatments
- Dietary Effects on Health
- Neonatal and Maternal Infections
- Pharmacological Effects of Natural Compounds
- Ferroptosis and cancer prognosis
- Sepsis Diagnosis and Treatment
- Epigenetics and DNA Methylation
Xiamen University
2024-2025
Sun Yat-sen University
2024
The First Affiliated Hospital, Sun Yat-sen University
2024
Calorie restriction (CR) is a dietary intervention used to promote health and longevity1,2. CR causes various metabolic changes in both the production circulation of metabolites1; however, it remains unclear which altered metabolites account for physiological benefits CR. Here we use metabolomics analyse that exhibit abundance during perform subsequent functional validation. We show lithocholic acid (LCA) one alone can recapitulate effects mice. These include activation AMP-activated protein...
Transmembrane-6 superfamily member 2 (TM6SF2) regulates hepatic fat metabolism and is associated with metabolic dysfunction-associated steatohepatitis (MASH). TM6SF2 genetic variants are steatotic liver disease. The pathogenesis of MASH involves factors gut microbiota alteration, yet the role host–microbe interactions in development remains unclear. Here, we discover that mice intestinal epithelial cell-specific knockout Tm6sf2 (Tm6sf2ΔIEC) develop MASH, accompanied by impaired barrier...
Abstract The shift of carbon utilization from primarily glucose to other nutrients is a fundamental metabolic adaptation cope with decreased blood levels and the consequent decline in oxidation. AMP-activated protein kinase (AMPK) plays crucial roles this adaptation. However, underlying mechanism not fully understood. Here, we show that PDZ domain containing 8 (PDZD8), which identify as new substrate AMPK activated low glucose, required for glucose-promoted glutaminolysis. phosphorylates...
Upon encountering antigens, B cells may undergo multiple differentiation paths, including becoming plasma and memory cells. Although it is well-known that transcription factors govern gene expression programs underpinning these fate decisions in transcriptional level, the role of post-transcriptional regulators, with a focus on RNA-binding proteins, determination are lesser known. Here we find by RNA interactome capture-coupled CRISPR/Cas9 functional screening Csde1-Strap complex plays an...
Objectives This study aims to investigate the diagnostic value of heparin-binding protein (HBP) in sepsis and develop a model incorporating HBP with key biomarkers disease-related scores for rapid, accurate diagnosis intensive care unit (ICU). Design Clinical retrospective cross-sectional study. Setting A comprehensive teaching tertiary hospital China. Participants Adult patients (aged ≥18 years) who underwent testing or whose blood samples were collected when admitted ICU. Main outcome...
Key Points Gene deletions of Zbp1 , Ripk3 and Mlkl reduced severity oxalate-induced AKI. Mice with mutation or deletion in the Z-nucleic acid sensing domain (Z α ) Z-DNA binding protein 1 were protected from sensed mitochondrial through its Z domain, recruited receptor-interacting kinase 3 homotypic interaction motif, activated mixed lineage domain-like to induce necroptosis. Background Calcium oxalate–induced acute kidney injury is a severe condition which kidneys suffer rapid damage due...
Dysregulated metabolism in tumor tissues, and para-tumor tissues alike, can lead to immunosuppression, which may underlie cancer development. However, metabolic intervention as a therapeutic strategy has been of no avail. In this study, we explored the anti-cancer effect aldometanib that specifically targets lysosome-associated aldolase mimic glucose starvation thereby activates lysosomal AMP-activated protein kinase (AMPK), master regulator homeostasis. We show inhibits growth HCC an...