A5010504879- RNA modifications and cancer
- Cancer-related gene regulation
- RNA Research and Splicing
- Peroxisome Proliferator-Activated Receptors
- Pancreatic function and diabetes
- Adipose Tissue and Metabolism
- Metabolism, Diabetes, and Cancer
- Nutritional Studies and Diet
- Mitochondrial Function and Pathology
- Natural Compounds in Disease Treatment
- Health Systems, Economic Evaluations, Quality of Life
- Arsenic contamination and mitigation
- Cell Adhesion Molecules Research
- ATP Synthase and ATPases Research
- Cancer-related molecular mechanisms research
- Nutrition and Health in Aging
- Circular RNAs in diseases
- Extracellular vesicles in disease
- Chronic Disease Management Strategies
- Frailty in Older Adults
- MicroRNA in disease regulation
- Platelet Disorders and Treatments
- Carcinogens and Genotoxicity Assessment
- Health disparities and outcomes
- Ubiquitin and proteasome pathways
Center for Life Sciences
2023-2024
Tsinghua University
2023-2024
Peking University
2023-2024
Second Affiliated Hospital of Zhejiang University
2023
Zhejiang University
2019-2023
Sir Run Run Shaw Hospital
2019-2023
Abstract Migrasomes are organelles that generated by migrating cells. Here we report the key role of neutrophil-derived migrasomes in haemostasis. We found a large number exist blood mice and humans. Compared with neutrophil cell bodies platelets, these adsorb enrich coagulation factors on surface. Moreover, they highly enriched adhesion molecules, which enable them to preferentially accumulate at sites injury, where trigger platelet activation clot formation. Depletion neutrophils, or...
Abstract The shift of carbon utilization from primarily glucose to other nutrients is a fundamental metabolic adaptation cope with decreased blood levels and the consequent decline in oxidation. AMP-activated protein kinase (AMPK) plays crucial roles this adaptation. However, underlying mechanism not fully understood. Here, we show that PDZ domain containing 8 (PDZD8), which identify as new substrate AMPK activated low glucose, required for glucose-promoted glutaminolysis. phosphorylates...
Abstract Obesity, one of the most serious public health issues, is caused by imbalance energy intake and expenditure. N(6)-methyladenosine (m 6 A) RNA modification has been recently identified as a key regulator obesity, while detailed mechanism elusive. Here, we find that YTH binding protein 1 (YTHDF1), an m A reader, acts essential white adipose tissue metabolism. The expression YTHDF1 decreases in male mice fed high-fat diet. Adipocyte-specific Ythdf1 deficiency exacerbates...
Upregulation of RNA polymerase (Pol) III products, including tRNAs and 5S rRNA, in tumor cells leads to enhanced protein synthesis formation, making it a potential target for cancer treatment. In this study, we evaluated the inhibition Pol transcription by triptolide anti-cancer effect drug colorectal tumorigenesis.The on development was assessed mouse models, 3D organoids, cultured cells. Colorectal were treated with triptolide. measured real-time quantitative chain reaction (PCR). The...
The induction of beige adipocytes in white adipose tissue (WAT), also known as WAT beiging, improves glucose and lipid metabolism. However, the regulation beiging at posttranscriptional level remains to be studied. Here, we report that METTL3, methyltransferase N6-methyladenosine (m6A) mRNA modification, is induced during mice. Adipose-specific depletion Mettl3 gene undermines impairs metabolic capability mice fed with a high-fat diet. Mechanistically, METTL3-catalyzed m6A installation on...
<p>The induction of beige adipocytes in white adipose tissue, also known as WAT beiging, improves glucose and lipid metabolism. However, the regulation beiging at posttranscriptional level remains to be studied. Here, we report that METTL3, methyltransferase N6-methyladenosine (m6A) mRNA modification, is induced during mice. Adipose-specific depletion <em>Mettl3</em> gene undermines impairs metabolic capability mice fed with a high-fat diet (HFD). Mechanistically,...
<p>The induction of beige adipocytes in white adipose tissue, also known as WAT beiging, improves glucose and lipid metabolism. However, the regulation beiging at posttranscriptional level remains to be studied. Here, we report that METTL3, methyltransferase N6-methyladenosine (m6A) mRNA modification, is induced during mice. Adipose-specific depletion <em>Mettl3</em> gene undermines impairs metabolic capability mice fed with a high-fat diet (HFD). Mechanistically,...
The shift of carbon utilisation from glucose to other nutrients is a fundamental metabolic adaptation cope with the decreased oxidation during fasting or starvation 1 . AMP-activated protein kinase (AMPK) plays crucial roles in manifesting physiological benefits accompanying calorie restriction 2 However, underlying mechanisms are unclear. Here, we show that low glucose-induced activation AMPK decisive role glutamine. We demonstrate endoplasmic reticulum (ER)-localised PDZD8, which identify...
Background: The induction of beige adipocytes in white adipose tissue (WAT), also known as WAT beiging, improves glucose and lipid metabolism. However, the function METTL3, methyltransferase N6-methyladenosine (m6A) mRNA modification, this process remains to be studied.Methods: Mettl3 conditional knockout mice were generated by mating Mettl3fl/fl with Adipoq-Cre mice. Beiging was successfully induced cold exposure (4 °C). histology expression thermogenic genes determined. RNA-sequencing,...