A5101998577- Pancreatic function and diabetes
- Heavy Metal Exposure and Toxicity
- Photoreceptor and optogenetics research
- Antioxidants, Aging, Portulaca oleracea
- Mitochondrial Function and Pathology
- Neuroscience and Neuropharmacology Research
- Aluminum toxicity and tolerance in plants and animals
- Calcium signaling and nucleotide metabolism
- Memory and Neural Mechanisms
- Metabolism, Diabetes, and Cancer
- Diet and metabolism studies
- Acute Kidney Injury Research
- Trace Elements in Health
- Electrochemical sensors and biosensors
- Pharmacological Effects of Natural Compounds
- Genetics, Aging, and Longevity in Model Organisms
- Cardiac and Coronary Surgery Techniques
- Cardiac, Anesthesia and Surgical Outcomes
Xiamen University
2019-2025
General Hospital of Shenyang Military Region
2023
University of Cincinnati Medical Center
2000
University of Cincinnati
1996
Fructose-1,6-bisphosphate (FBP) aldolase links sensing of declining glucose availability to AMPK activation via the lysosomal pathway. However, how transmits lack occupancy by FBP remains unclear. Here, we show that FBP-unoccupied interacts with and inhibits endoplasmic reticulum (ER)-localized transient receptor potential channel subfamily V, inhibiting calcium release in low glucose. The decrease at contact sites between ER lysosome renders inhibited TRPV accessible bind v-ATPase then...
Calorie restriction (CR) is a dietary intervention used to promote health and longevity1,2. CR causes various metabolic changes in both the production circulation of metabolites1; however, it remains unclear which altered metabolites account for physiological benefits CR. Here we use metabolomics analyse that exhibit abundance during perform subsequent functional validation. We show lithocholic acid (LCA) one alone can recapitulate effects mice. These include activation AMP-activated protein...
Off-pump coronary artery bypass grafting-associated acute kidney injury (OPCAB-AKI) is related to 30-day perioperative mortality. Existing mathematical models cannot be applied help clinicians make early diagnosis and intervention decisions.
The shift of carbon utilisation from glucose to other nutrients is a fundamental metabolic adaptation cope with the decreased oxidation during fasting or starvation 1 . AMP-activated protein kinase (AMPK) plays crucial roles in manifesting physiological benefits accompanying calorie restriction 2 However, underlying mechanisms are unclear. Here, we show that low glucose-induced activation AMPK decisive role glutamine. We demonstrate endoplasmic reticulum (ER)-localised PDZD8, which identify...