A5026371074- Diet and metabolism studies
- Gut microbiota and health
- Health disparities and outcomes
- Chronic Disease Management Strategies
- Probiotics and Fermented Foods
- Nutritional Studies and Diet
- Liver Disease Diagnosis and Treatment
- Health Systems, Economic Evaluations, Quality of Life
- MicroRNA in disease regulation
- Inflammatory Biomarkers in Disease Prognosis
- Adipokines, Inflammation, and Metabolic Diseases
- Retinoids in leukemia and cellular processes
- Agriculture Sustainability and Environmental Impact
- Carcinogens and Genotoxicity Assessment
- Peroxisome Proliferator-Activated Receptors
- Arsenic contamination and mitigation
- Diabetes Treatment and Management
- Natural Compounds in Disease Treatment
- Cancer survivorship and care
- Psychosomatic Disorders and Their Treatments
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Algal biology and biofuel production
- Gout, Hyperuricemia, Uric Acid
- Cardiovascular Health and Disease Prevention
- Ubiquitin and proteasome pathways
Sun Yat-sen University
2022-2025
Sir Run Run Shaw Hospital
2019-2025
Zhejiang University
2019-2025
State Key Laboratory of Food Science and Technology
2024
Second Affiliated Hospital of Zhejiang University
2021-2023
Zhejiang A & F University
2020
Dysbiosis of gut microbiota plays a pivotal role in vascular dysfunction and microbial diversity was reported to be inversely correlated with arterial stiffness. However, the causal progression stiffness specific species along molecular mechanisms underlying this change remain largely unknown.Participants elevated normal controls free medication were matched for age sex. The composition metabolic capacities between 2 groups compared integration metagenomics metabolomics. Subsequently, Ang II...
Abstract Diet rich in chicken protein has gained a widespread popularity for its profound effect on weight loss and glycemic control; however, long‐term cardiovascular health the underlying mechanisms remains obscure. Here, we demonstrated that higher intake of was an independent risk factor sub‐clinical atherosclerosis. Adherence to high diet (HCD) alleviated excessive gain control regardless presence gut microbiota apolipoprotein E–deficient mice. In contrast, HCD administration enhanced...
Infertility presents a substantial challenge for women of reproductive age, exerting profound effects on both individual well-being and healthcare systems. Despite its critical role in folate homocysteine pathways, the influence methylenetetrahydrofolate reductase (MTHFR) success assisted techniques (ART) remains insufficiently understood. This knowledge gap impedes development personalized therapeutic strategies. Our study seeks to elucidate relationship between MTHFR ART outcomes,...
Upregulation of RNA polymerase (Pol) III products, including tRNAs and 5S rRNA, in tumor cells leads to enhanced protein synthesis formation, making it a potential target for cancer treatment. In this study, we evaluated the inhibition Pol transcription by triptolide anti-cancer effect drug colorectal tumorigenesis.The on development was assessed mouse models, 3D organoids, cultured cells. Colorectal were treated with triptolide. measured real-time quantitative chain reaction (PCR). The...
Evidence has suggested the potential of tumor-educated platelets as a biomarker trove for cancer diagnostics, but difficulty in isolation limits its application. Since most circulating RNAs are derived from platelets, change RNA profile may lead to altered expression serum. Here, we identified panel platelet-associated long non-coding (lncRNAs) and evaluated diagnostic capacity serum colorectal (CRC) patients. Four lncRNAs, LNCAROD, SNHG20, LINC00534, TSPOAP-AS1, were upregulated both CRC A...
Non-high-density lipoprotein cholesterol (non-HDL-c) was a strong risk factor for incident cardiovascular diseases and proved to be better target of lipid-lowering therapies. Recently, gut microbiota has been implicated in the regulation host metabolism. However, its causal role variation non-HDL-c remains unclear. Microbial species metabolic capacities were assessed with fecal metagenomics, their associations evaluated by Spearman correlation, followed LASSO linear regression adjusted...
Retinol binding protein 4 (RBP4) has been implicated in the progression of cardiovascular diseases. However, its association with major adverse events (MACEs) patients acute coronary syndrome (ACS) remains obscure.Here, we examined prognostic value baseline RBP4 and derived multimarker score for MACEs ACS patients.A total 826 were consecutively recruited from department cardiology prospectively followed up a median 1.95 years (interquartile range, 1.02-3.25 years). Plasma was measured using...
Background: Though emerging evidence suggests a modulatory effect of sleep behaviors on gut microbiota, the dysbiosis which is implicated in development fatty liver, whether and how microbial metabolism link quality to hepatic steatosis remain obscure. Methods: Integrative analysis metagenomics metabolomics were performed 1,384 community residents. Hepatic was evaluated, collected through Pittsburgh Sleep Quality Index questionnaire. Findings: After adjustment for demographics, lifestyles...
Background: Body pain was associated with many individual somatic and mental chronic conditions, but the association of body multimorbidity (SMM) remains unclear. We aimed to evaluate prevalence onset SMM patterns.Methods: Participants aged ≥45 years at baseline (2011) from China Health Retirement Longitudinal Study were included. included sites in head, neck/shoulder, upper limb, torso, lower limb. Five patterns categorized by number condition (MC, depression) conditions (SC): 1 MC, SC, SC...