A5039752340- Inflammasome and immune disorders
- Acute Kidney Injury Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Kidney Stones and Urolithiasis Treatments
- Renal and related cancers
- Single-cell and spatial transcriptomics
- Liver Disease Diagnosis and Treatment
- Forensic and Genetic Research
- Systemic Lupus Erythematosus Research
- Vasculitis and related conditions
- Liver Diseases and Immunity
First Affiliated Hospital of Fujian Medical University
2022-2024
Fujian Medical University
2022-2024
Renal fibrosis is a common consequence of various progressive nephropathies, including obstructive nephropathy, and ultimately leads to kidney failure. Infiltration inflammatory cells prominent feature renal injury after draining blockages from the kidney, correlates closely with development fibrosis. However, underlying molecular mechanism behind promotion by remains unclear. Herein, we showed that unilateral ureteral obstruction (UUO) induced Gasdermin D (GSDMD) activation in neutrophils,...
ABSTRACT Background and hypothesis Acute kidney injury (AKI) could progress to chronic disease (CKD) the AKI-CKD transition has major clinical significance. A growing body of evidence unveiled role pyroptosis in injury. We postulate that GSDMD GSDME exert cumulative effects on by modulating different cellular responses. Methods established an model induced folic acid wildtype (WT), Gsdmd−/−, Gsdme−/−, Gsdmd−/−Gsdme−/− mice. Tubular injury, renal fibrosis inflammatory responses were...
Abstract Homogeneity and heterogeneity of the cytopathological mechanisms in different etiology-induced acute kidney injury (AKI) are poorly understood. Here, we performed single-cell sequencing (scRNA) on mouse kidneys with five common AKI etiologies (CP-Cisplatin, IRI-Ischemia-reperfusion injury, UUO-Unilateral ureteral obstruction, FA-Folic acid, SO-Sodium oxalate). We constructed a potent multi-model scRNA atlas containing 20 celltypes 80,689 high-quality cells. The data suggest that...
Key Points Gene deletions of Zbp1 , Ripk3 and Mlkl reduced severity oxalate-induced AKI. Mice with mutation or deletion in the Z-nucleic acid sensing domain (Z α ) Z-DNA binding protein 1 were protected from sensed mitochondrial through its Z domain, recruited receptor-interacting kinase 3 homotypic interaction motif, activated mixed lineage domain-like to induce necroptosis. Background Calcium oxalate–induced acute kidney injury is a severe condition which kidneys suffer rapid damage due...
A comprehensive bioinformatics analysis was conducted to investigate potential new diagnostic biomarkers and immune infiltration characteristics associated with tubulointerstitial injury in lupus nephritis (LN), examine possible correlations between key genes infiltrating cells. The GSE32591, GSE113342, GSE200306 datasets were downloaded from the Gene Expression Omnibus database differentially expressed (DEGs) identified pooled dataset. Support vector machine-recursive feature elimination...