A5074689589- Chronic Obstructive Pulmonary Disease (COPD) Research
- Inflammasome and immune disorders
- Hormonal Regulation and Hypertension
- Autoimmune and Inflammatory Disorders Research
- Traditional Chinese Medicine Studies
- Streptococcal Infections and Treatments
- Blood Pressure and Hypertension Studies
- Health and Wellbeing Research
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Cerebrovascular and Carotid Artery Diseases
- Systemic Lupus Erythematosus Research
- Medical Research and Treatments
- Autophagy in Disease and Therapy
- Respiratory Support and Mechanisms
- Cardiac Ischemia and Reperfusion
- Mathematical Approximation and Integration
- Phosphodiesterase function and regulation
- Acute Ischemic Stroke Management
- Parkinson's Disease Mechanisms and Treatments
- Gastrointestinal motility and disorders
- Lipid metabolism and disorders
- Nuclear Receptors and Signaling
- Cardiovascular Health and Risk Factors
- Adrenal Hormones and Disorders
- Gout, Hyperuricemia, Uric Acid
Guangxi Medical University
2020-2025
First Affiliated Hospital of GuangXi Medical University
2020-2025
Fujian Medical University
2024
Dongguan People’s Hospital
2011-2017
State Key Laboratory of Respiratory Disease
2007-2008
Guangzhou Medical University
2007-2008
Sun Yat-sen University
2004-2007
Third Affiliated Hospital of Sun Yat-sen University
2006-2007
Chinese University of Hong Kong
2004-2006
The First Affiliated Hospital, Sun Yat-sen University
2004
Cerebral white matter changes (WMC) and lacunar infarct are both believed to be consequence of small vessel disease. Whether the extent WMC affect type degree cognitive impairment in patients with is not clear. The study was undertaken determine if influences cognition infarcts. We recruited consecutive who were admitted acute stroke unit because infarcts, mainly documented by diffusion-weighted magnetic resonance imaging. measured qualitatively quantitatively. Patients divided into...
MicroRNA (miR)-143-3p is a potential regulatory molecule in myocardial ischemia/reperfusion injury (MI/RI), wherein its expression and pathological effects remains controversial. Thus, mouse MI/RI cell hypoxia/reoxygenation (H/R) models were built for clarifying the miR-143-3p's role MI/RI. Following ischemia 30 min, mice underwent reperfusion 3, 6, 12 24 h. It was found miR-143-3p increased ischemic heart tissue over time after reperfusion. Cardiomyocytes transfected with more susceptible...
Environmental and genetic factors may both affect the risk of vascular cognitive impairment developing after a stroke. To identify affecting this risk, status 121 patients was examined 3 months an ischemic In all in 270 control subjects, 7 polymorphisms reported to disease were genotyped. 51 (42.1%), resulted, defined by Mini-Mental State Examination score less than 24. These older more likely be women. Alleles none differed between with or without impairment, except for glutamate-cysteine...
Background: Rheumatic heart disease (RHD) is caused by inflammatory cells mistakenly attacking the valve due to Group A Streptococcus (GAS) infection, but it still unclear which or genes are involved in process of infiltrating valve. Inflammatory infiltration into target tissue requires an increase expression phosphorylated vascular endothelial-cadherin (p-VE-cad), p-VE-cad can endothelial permeability and promote migration across endothelium. P-VE-cad potentially regulated RAS-related C3...
The relationship between the apolipoprotein E (APOE) exon 4 polymorphism and white matter changes (WMC) in elderly subjects or patients with Alzheimer's disease is controversial. To investigate this relation to WMC lacunar infarcts, we prospectively observed 67 acute infarct 134 age‐ sex‐matched controls. Genotypes were determined using a nested polymerase chain reaction. measured quantitatively divided into two groups, severe mild, mean volume of as cut point. Twenty‐two (33%) had WMC....
Rheumatic heart disease (RHD) affects numerous individuals annually; however, its pathogenesis remains unclear. The sphingosine 1‑phosphate receptor 1 (S1PR1) and signal transducer activator of transcription 3 (STAT3) have recently been shown to be involved in valvular damage via the promotion differentiation T helper 17 (Th17) cells during development RHD‑induced damage. present study investigated whether altering expression S1PR1 or STAT3 attenuates due RHD. Inactivated group A...
Purpose: To investigate the role of renal denervation (RDN) on endogenous ouabain (EO) secretion in spontaneously hypertensive rats (SHR). Methods: Sixteen 12-week-old male SHR were randomly separated into group (RDNX group) and sham operation (sham group), eight age-matched Wistar Kyoto (WKY) served as control group. EO concentrations, Na+- K+-ATPaseactivity, expression Na+-K+-ATPase assessed. Results: levels serum, kidneys hypothalamus higher than RDNX (p < 0.05). Renal activity subjected...
Dysregulated metabolism in tumor tissues, and para-tumor tissues alike, can lead to immunosuppression, which may underlie cancer development. However, metabolic intervention as a therapeutic strategy has been of no avail. In this study, we explored the anti-cancer effect aldometanib that specifically targets lysosome-associated aldolase mimic glucose starvation thereby activates lysosomal AMP-activated protein kinase (AMPK), master regulator homeostasis. We show inhibits growth HCC an...
Here, we aimed to study the important cytokines in plasma identify aldosterone-producing adenoma (APA). 19 unilateral primary aldosteronism (UPA) patients and healthy people were divided into UPA group Control group, serum of bilateral adrenal veins inferior vena cava collected by blood sampling (AVS) from subjects all used detect multiple Luminex immunoassays. Additionally, The subjected laparoscopic adrenalectomy different groups pathological results for further study. According our...
Long-QT syndrome type 2 (LQT2) is a life-threatening Mendelian disease caused by genetic variants in KCNH2. Herein, we generated human embryonic stem cell line (WAe009-A-88) carrying LQT2 related mutation KCNH2, c.1720 A>G. The WAe009-A-88 maintained cell-like morphology, expressed high levels of pluripotent markers, had normal karyotype, and could differentiate into all three germ layers vivo. can serve as valuable tools for modeling vitro investigating the pathological mechanisms to KCNH2...
Objective To investigate the correlation between pulmonary function and left ventricular ejection fraction(LVEF) in chronic heart failure(CHF) patients. Methods 101 patients from January 2008 to May 2010 our hospital for failure treatment were chosen, divided into two groups according LVEF levels: EF decrease group (EF value of 50%) normal values＞50%). Pulmonary was observed FVC, FEV1, FEV 1%, FVC%, PEF%, TLCO-SB% difference groups. Results Compared with group, 1%,FVC% declined had...
Objective To study the effect of multimedia healthy education on lung function test.Methods Totals 851 cases between March 2009 and September 2011 were randomly divided into routine group ( n =427 ) =424 ).The quality forced vital capacity examination two groups observed.Results The target rate exterpolation volume respectively 87.82％ 93.16％,and difference was statistically significant x2 =7.04,P ＜0.01 repeatability 81.97％ 87.50,and finish time less 10 min 85.95％ 92.45％ groups,and...
[Objective]To evaluate the efficacy of antidepressant drug therapy in COPD-associated depression.[Methods]Outpatients were evaluated with moderate to severe,stable COPD completed Hospital Anxiety and Depression (HAD).Those psychiatrist interviewed high score s [HADS scale(anxiety or depression score) ＞ 10]were brought into study.Depressed anxious patients took a selective serotonin reuptake inhibitor,paroxetine 20 mg daily.All paroxetine for 16 weeks.After 2,8,12 weeks,the HADS was...
Objective To explore the effects of continuous versus interval trainings for patients with chronic obstructive pulmonary disease (COPD). Methods This was a controlled, prospective randomized study. 35 COPD took part in rehabilitation program and were randomly divided into group an group. Among patients, 29 completed program, 15 14 9 set as control Bicycle exercise training conducted 2 days each week 12 weeks. The trained intensity corresponding to Borg scale 4 (moderate dyspnea) 30...