A5100685558- Hormonal Regulation and Hypertension
- Head and Neck Cancer Studies
- RNA modifications and cancer
- Chronic Lymphocytic Leukemia Research
- Ferroptosis and cancer prognosis
- Adrenal Hormones and Disorders
- Natural Language Processing Techniques
- Cancer, Lipids, and Metabolism
- Cardiac Ischemia and Reperfusion
- Machine Learning in Bioinformatics
- Airway Management and Intubation Techniques
- Gastrointestinal Tumor Research and Treatment
- Anesthesia and Neurotoxicity Research
- MicroRNA in disease regulation
- Phytochemicals and Antioxidant Activities
- Antifungal resistance and susceptibility
- Blood Pressure and Hypertension Studies
- Fungal Infections and Studies
- Cancer Research and Treatments
- Cancer-related gene regulation
- Adrenal and Paraganglionic Tumors
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Dietary Effects on Health
- Topic Modeling
- Sodium Intake and Health
Guangxi Medical University
2012-2025
Xinxiang Central Hospital
2014-2025
First Affiliated Hospital of GuangXi Medical University
2012-2025
Xihua University
2025
Qinghai University
2025
Chengde Medical University
2022-2024
Xinxiang Medical University
2024
First Affiliated Hospital of Jinan University
2019-2024
Xiangya Hospital Central South University
2008-2023
Central South University
2008-2023
Single-agent ibrutinib has shown substantial activity in patients with relapsed Waldenström's macroglobulinemia, a rare form of B-cell lymphoma. We evaluated the effect adding to rituximab this disease, both those who had not received previous treatment and disease recurrence.We randomly assigned 150 symptomatic receive plus or placebo rituximab. The primary end point was progression-free survival, as assessed by an independent review committee. Key secondary points were response rates,...
BACKGROUND AND PURPOSE Inflammation is involved in the development and/or progression of many diseases including diabetic complications. Investigations on novel anti‐inflammatory agents may offer new approaches for prevention nephropathy. Our previous bioscreening synthetic analogues curcumin revealed C66 as a compound against LPS challenge macrophages. In this study, we hypothesized that affects high glucose (HG)‐induced inflammation profiles vitro and vivo then prevents renal injury rats...
Abstract Background Exposure to antibiotics predisposes dysbiosis and Clostridioides difficile infection (CDI) that can be severe, recurrent (rCDI), life-threatening. Nonselective drugs treat CDI perpetuate are associated with rCDI, in part due loss of microbiome-derived secondary bile acid (SBA) production. Ridinilazole is a highly selective drug designed prevent rCDI. Methods In this phase 3 superiority trial, adults CDI, confirmed stool toxin test, were randomized receive 10 days...
Abstract Background The prognosis for many cancers could be improved dramatically if they detected while still at the microscopic disease stage. It follows from a comprehensive statistical analysis that number of antigens such as hTERT, PCNA and Ki-67 can considered cancer markers, another set P27KIP1 FHIT are possible markers normal tissue. Because more than one marker must to obtain classification or no cancer, classify it malignant, borderline, benign, we develop an intelligent decision...
Accumulating evidence has suggested an oncogenic effect of diurnal disruption on cancer progression. To test whether targeting circadian rhythm by dietary strategy suppressed lung progression, we adopted 6-h time-restricted feeding (TRF) paradigm to elucidate and how TRF impacts progression.This study used multiple cell lines, two xenograft mouse models, a chemical-treated model. Stable TIM-knockdown TIM-overexpressing A549 cells were constructed. Cancer behaviors in vitro determined colony...
Isolates of Candida africana and C. dubliniensis were recovered from patients with vulvovaginal candidiasis (VVC). The isolates initially identified as albicans through use the API System. We retrospectively reexamined 1014 vaginal presumptively determined to be at Department Obstetrics Gynecology Peking University Shenzhen Hospital 1 January 2003 31 December 2012. Our objective was determine, via detection HWP1 gene, if any or dubliniensis. One a half percent these (15/1014) found africana,...
Phytosterols (PS) showed anti-inflammatory activities in acute lung injury (ALI), but the mechanism needs to be further elucidated. In this study, male C57BL/6J mice were gavaged with PS (75 mg/kg or 150 mg/kg) for 7 consecutive days, ALI induced by tracheal instillation of LPS (50 μL, 1 mg/mL). vitro, RAW264.7 cells incubated presence absence 50 μM β-sitosterol. Enzyme-linked immunosorbent assay was used detect levels inflammatory cytokines. Real-time quantitative PCR and western blot...
To identify novel proteins associated with the pathogenesis of nasopharyngeal carcinoma (NPC), a proteomic approach was used to screen for differential between NPC and adjacent noncancerous epithelial tissue (ANNET). As result, 21 were identified by two-dimensional electrophoresis mass spectrometer. Raf kinase inhibitor protein (RKIP), one downregulated in compared ANNET, investigated its role metastasis NPC. Western blot analysis immunohistochemistry detect RKIP expression 5-8F 6-10B cell...
Radiology reports play a critical role in communicating medical findings to physicians.In each report, the impression section summarizes essential radiology findings.In clinical practice, writing is highly demanded yet time-consuming and prone errors for radiologists.Therefore, automatic generation has emerged as an attractive research direction facilitate such practice.Existing studies mainly focused on introducing salient word information general text summarization framework guide...
Objective: Primary aldosteronism (PA) is the most common secondary hypertension. In this study, we performed pathway enrichment analysis based on metabolomics and transcriptomic data to find metabolic perturbations in PA, which could provide new targets for PA further understand biology of PA. Methods: 24 patients healthy adults served as control group study. Six participants were chosen from each have their peripheral blood serum samples analyzed omics investigations. Another eighteen...
Triton, a high-level Python-like language designed for building efficient GPU kernels, is widely adopted in deep learning frameworks due to its portability, flexibility, and accessibility. However, programming parallel optimization still require considerable trial error from Triton developers. Despite advances large models (LLMs) conventional code generation, these struggle generate accurate, performance-optimized code, as they lack awareness of specifications the complexities programming....
BACKGROUND Experts and experience in the medical profession are required for diagnosis of pelvic endometriosis. The objective this study was to compare diagnostic parameters transvaginal ultrasound versus magnetic resonance imaging (MRI) diagnose MATERIAL AND METHODS Our analysis included results examinations, MRI scans, laparoscopy histopathologic evaluation 144 women who had positive examination RESULTS Transvaginal scans inferior a higher clinical risk missing endometriosis than...
With the continuous advancement of precision nutrition, researchers have increasingly recognized need for tailored, stable delivery food bioactive compounds, such as anthocyanins, in response to varying conditions gastrointestinal (GI) environment. In this proof-of-concept study, we hypothesize that by modulating number pH-responsive -COOH groups peptide gels, can precisely control their pH responsiveness, rheological properties, and other physicochemical characteristics, enabling efficient...
The unique climatic conditions of Qinghai are highly suitable for the growth goji berry (Lycium barbarum), with superior yield and quality to other production areas. Screening areas similar can guide scientific cultivation high-yield high-quality berry, thereby increasing income. Based on characteristics area, we utilized optimized MaxEnt model ArcGIS identify key meteorological factors affecting distribution habitats predict under different climate scenarios. results showed that feature...
Background: The aim of this study was to describe the sleep quality and its influencing factors among medical workers different working statuses staff types during coronavirus disease 2019 (COVID-19) epidemic. Methods: Through an online questionnaire survey, all staffs in Xiangya Hospital were invited complete sections on general information, Self-Rating Scale Sleep (SRSS), Depression, Anxiety Stress (DASS-21), Social Support Rating (SSRS), Simplified Coping Style Questionnaire (CSQ)....
Cardiomyopathy is particularly common in septic patients. Our previous studies have shown that activation of the alpha 1 adrenergic receptor (α
Objective: Osteocalcin can regulate energy metabolism and increase testosterone production. Although previous studies have shown the positive association between osteocalcin testosterone, effect of metabolic factors in is unclear. Design Setting: Osteocalcin, were accessed 2400 men aged 20 to 69 years, who participated population-based Fangchenggang Area Male Health Examination Survey Guangxi province China from September 2009 December 2009. Main Outcome Measures: Metabolic syndrome was...