Evaluation on efficacy of long period antidepressant drug therapy in COPD-associated depression

• DOI: 10.3760/cma.j.issn.1007-1245.2012.14.017
• Publication Date: 2012-07-15
• Authors: Hong Wen; Li Xu; Xue-zhen Ou; Ping Zhang; Nian-qiang Deng
• Keywords: Depression; Paroxetine

[Objective]To evaluate the efficacy of antidepressant drug therapy in COPD-associated depression.[Methods]Outpatients were evaluated with moderate to severe,stable COPD completed Hospital Anxiety and Depression (HAD).Those psychiatrist interviewed high score s [HADS scale(anxiety or depression score) ＞ 10]were brought into study.Depressed anxious patients took a selective serotonin reuptake inhibitor,paroxetine 20 mg daily.All paroxetine for 16 weeks.After 2,8,12 weeks,the HADS was repeated.[Results]Among 41outpatients who entered study,29 study.Anxiety (only anxiety 10) indicated 9 patienta 5,anxiety (HADS anxiety+depression all 15.12 weeks' treatment produced significant improvement either depression(P＜ 0.05).However,there no differences scales at 12 weeks weeks(P＞ 0.05).[Conclusion]We conclude that least can produce depression.Longer period could not acquire better curative effect.

Key words: Chronic obstructive pulmonary disease; Anxiety; Depression; Drug