Jarrett D. Morrow
A5004570027- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neonatal Respiratory Health Research
- Epigenetics and DNA Methylation
- Asthma and respiratory diseases
- Antenna Design and Analysis
- Microwave Engineering and Waveguides
- Respiratory Support and Mechanisms
- Delphi Technique in Research
- Pediatric health and respiratory diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Childhood Cancer Survivors' Quality of Life
- Advanced Antenna and Metasurface Technologies
- RNA modifications and cancer
- Genetic Associations and Epidemiology
- Cancer-related gene regulation
- Air Quality and Health Impacts
- Cancer-related molecular mechanisms research
- IL-33, ST2, and ILC Pathways
- Pleural and Pulmonary Diseases
- Congenital Diaphragmatic Hernia Studies
- Dementia and Cognitive Impairment Research
- Pulmonary Hypertension Research and Treatments
- Bioinformatics and Genomic Networks
- Lung Cancer Diagnosis and Treatment
- Hepatitis C virus research
Harvard University
2014-2024
Brigham and Women's Hospital
2015-2024
Harvard University Press
2022
Vision Technology (United States)
2021
University of New Hampshire
1992-2012
Johns Hopkins University
2012
Computercraft (United States)
2004
University of Houston
1994-2002
In utero smoke exposure has been shown to have detrimental effects on lung function and be associated with persistent wheezing asthma in children. One potential mechanism of IUS could alterations DNA methylation, which may life-long implications. The goal this study was examine the association between methylation nicotine fetal placental tissue early development; analysis represents a likely surrogate for in-utero smoke. We performed an epigenome-wide (n = 85, 41 exposed (48%), 44 controls)...
In comparison to genome-wide association studies (GWAS), there has been poor replication of gene expression in chronic obstructive pulmonary disease (COPD). We performed microarray profiling on a large sample resected lung tissues from subjects with severe COPD. Comparing 111 COPD cases and 40 control smokers, 204 genes were differentially expressed; none at significant GWAS loci. The top expressed was HMGB1, which interacts AGER, known gene. Differentially showed enrichment for putative...
Cardiovascular disease (CVD) is the most important comorbidity in patients with chronic obstructive pulmonary (COPD). COPD exacerbations not only contribute to progression but may also elevate risk of CVD. This study aimed determine whether increase subsequent CVD events using up 15 years prospective longitudinal follow-up data from COPDGene (Genetic Epidemiology Chronic Obstructive Pulmonary Disease) study.
Chronic obstructive pulmonary disease (COPD) is a smoking-related characterized by genetic and phenotypic heterogeneity. Although association studies have identified multiple genomic regions with replicated associations to COPD, variation only partially explains the susceptibility lung disease, suggests relevance of epigenetic investigations. We performed genome-wide DNA methylation profiling in homogenized tissue samples from 46 control subjects normal function 114 all former smokers. The...
As the third leading cause of death in United States, impact chronic obstructive pulmonary disease (COPD) makes identification its molecular mechanisms great importance. Genome-wide association studies (GWASs) have identified multiple genomic regions associated with COPD. However, genetic variation only explains a small fraction susceptibility to COPD, and sub-genome-wide significant loci may play role pathogenesis.
Exacerbations of chronic obstructive pulmonary disease (COPD), characterized by acute deterioration in symptoms, may be due to bacterial or viral infections, environmental exposures, unknown factors. Exacerbation frequency a stable trait COPD patients, which could imply genetic susceptibility. Observing the genes, networks, and pathways that are up- down-regulated patients with differing susceptibility exacerbations will help elucidate molecular signature pathogenesis exacerbations.Gene...
Multiple gene expression studies have been performed separately in peripheral blood, lung, and airway tissues to study COPD. We RNA-sequencing profiling of large-airway epithelium, alveolar macrophage blood samples from the same subset COPD cases controls COPDGene who underwent bronchoscopy at a single center. Using statistical set enrichment approaches, we sought improve understanding by studying sets pathways across these tissues, beyond individual genomic determinants. differential...
Cigarette smoking contributes to the risk of death through different mechanisms.
The space-filling fractal geometry of the Hilbert curve is examined in terms its effectiveness lowering resonant frequency. It demonstrated that complex associated with inherently ineffective frequency compared to other less geometries same size and total wire length. a direct function current vector alignment established by layout.
Chronic obstructive pulmonary disease (COPD) is a phenotypically heterogeneous disease. In COPD, the presence of emphysema associated with increased mortality and risk lung cancer. High resolution computed tomography (HRCT) scans are useful in quantifying but radiation exposure high incidence false positive findings (i.e., nodules). Using comprehensive biomarker panel, we sought to determine if there was peripheral blood signature emphysema. 114 plasma biomarkers were measured using custom...
Section:ChooseTop of pageAbstract <<Materials and MethodsResultsDiscussionReferencesCITING ARTICLES
Chronic obstructive pulmonary disease (COPD) is the third-leading cause of death worldwide. Identifying COPD-associated DNA methylation marks in African-Americans may contribute to our understanding racial disparities COPD susceptibility. We determined differentially methylated genes and co-methylation network modules associated with recruited during exacerbations smoking controls from Pennsylvania Study Obstructive Pulmonary Exacerbations (PA-SCOPE) cohort. assessed whole blood samples 362...
Rationale: Chronic obstructive pulmonary disease (COPD) susceptibility is in part related to genetic variants. Most studies have been focused on genome-wide common variants without a specific focus coding variants, but and rare may also affect COPD susceptibility.Objectives: To identify associated with COPD.Methods: We tested nonsynonymous, splice, stop derived from the Illumina HumanExome array for association five study populations enriched COPD. evaluated single minor allele frequency...
Abstract Chronic obstructive pulmonary disease (COPD) is a complex and heterogeneous syndrome. Network-based analysis implemented by SWIM software can be exploited to identify key molecular switches - called “switch genes” for the disease. Genes contributing common biological processes or defining given cell types are usually co-regulated co-expressed, forming expression network modules. Consistently, we found that COPD correlation built consists of three well-characterized modules: one...
Acute exacerbations of chronic obstructive pulmonary disease (AE-COPDs) are associated with a significant burden. Blood immune phenotyping may improve our understanding COPD endotype at increased risk exacerbations.
Genomic regions identified by genome-wide association studies explain only a small fraction of heritability for chronic obstructive pulmonary disease (COPD). Alpha-1 antitrypsin deficiency shows that rare coding variants large effect also influence COPD susceptibility. We hypothesized exome sequencing in families through proband with severe, early-onset would identify additional genetic determinants effect.To severe COPD.We applied filtering approaches to potential causal whole exomes from...
Multiple studies have demonstrated an increased risk of chronic obstructive pulmonary disease (COPD) in heterozygous carriers the AAT (alpha-1 antitrypsin) Z allele. However, it is not known if MZ subjects with COPD are phenotypically different from noncarriers (MM genotype) COPD.
Chronic obstructive pulmonary disease (COPD) and idiopathic fibrosis (IPF) are characterized by shared exposures clinical features, but distinct genetic pathologic features exist. These have not been well-studied using large-scale gene expression datasets. We hypothesized that there divergent gene, pathway, cellular signatures between COPD IPF.We performed RNA-sequencing on lung tissues from individuals with IPF (n = 231) 377) compared to control 267), defined as normal spirometry. grouped...
Cigarette smoking has a significant impact on global health. Although cessation positive health benefits, some molecular changes to intercellular communications may persist in the lung. In this study we created framework generate hypotheses by predicting altered cell-cell communication smoker lungs using single-cell and spatial transcriptomic data. We integrated publicly available lung data with from never-smoker current-smoker tissue samples create at virtual resolution mapping individual...
Section:ChooseTop of pageAbstract <<Materials and MethodsResultsDiscussionReferencesCITING ARTICLES
Background Patterns of gene expression human pregnancy are poorly understood. In a trial vitamin D supplementation in pregnant women, peripheral blood transcriptomes were measured longitudinally on 30 women and used to characterize co-expression networks. Objective Studies suggest that increased maternal Vitamin levels may reduce the risk asthma early life, yet underlying mechanisms have not been examined. this study, we network-based approach examine changes profiles during course normal...
Genome-wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) significantly associated with chronic obstructive pulmonary disease (COPD). However, many genetic variants show suggestive evidence for but do not meet the strict threshold genome-wide significance. Integrative analysis of multiple omics datasets has potential to identify novel genes involved in pathogenesis by leveraging these a functional, regulatory context.We performed expression quantitative...