Pietro Nardelli
A5043665507- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pulmonary Hypertension Research and Treatments
- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Venous Thromboembolism Diagnosis and Management
- Respiratory Support and Mechanisms
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cardiac Imaging and Diagnostics
- Medical Imaging and Pathology Studies
- Cardiovascular Function and Risk Factors
- Asthma and respiratory diseases
- Pediatric health and respiratory diseases
- Respiratory and Cough-Related Research
- Tracheal and airway disorders
- Cardiovascular Disease and Adiposity
- Ultrasound in Clinical Applications
- Cystic Fibrosis Research Advances
- Advanced X-ray and CT Imaging
- Radiation Dose and Imaging
- COVID-19 diagnosis using AI
- Neonatal Respiratory Health Research
- Inhalation and Respiratory Drug Delivery
- Parasites and Host Interactions
- Advanced Radiotherapy Techniques
- Atrial Fibrillation Management and Outcomes
Brigham and Women's Hospital
2016-2024
Harvard University
2016-2024
Vall d'Hebron Hospital Universitari
2023
Gentofte Hospital
2023
IRCCS Humanitas Research Hospital
2022
Humanitas University
2022
University of Colorado Anschutz Medical Campus
2022
Colorado School of Public Health
2022
Laboratory Imaging (Czechia)
2019
University College Cork
2014-2017
Recent studies show that pulmonary vascular diseases may specifically affect arteries or veins through different physiologic mechanisms. To detect changes in the two trees, physicians manually analyze chest computed tomography (CT) image of patients search abnormalities. This process is time consuming, difficult to standardize, and thus not feasible for large clinical useful real-world decision making. Therefore, automatic separation CT images becoming great interest, as it help accurately...
Cor pulmonale (right ventricular [RV] dilation) and cor parvus (RV shrinkage) are both described in chronic obstructive pulmonary disease (COPD). The identification of emphysema as a shared risk factor suggests that additional characterization is needed to understand these widely divergent cardiac processes.
Prior studies of clinical prognostication in idiopathic pulmonary fibrosis (IPF) using computed tomography (CT) have often used subjective analyses or evaluated quantitative measures isolation. This study examined associations between both densitometric and local histogram based CT measurements with function test (PFT) parameters mortality. In addition, this sought to compare risk prediction scores that incorporate previously described systems.Forty six patients biopsy proven IPF were...
Cardiovascular disease (CVD) is the most important comorbidity in patients with chronic obstructive pulmonary (COPD). COPD exacerbations not only contribute to progression but may also elevate risk of CVD. This study aimed determine whether increase subsequent CVD events using up 15 years prospective longitudinal follow-up data from COPDGene (Genetic Epidemiology Chronic Obstructive Pulmonary Disease) study.
Background Exposure to cigarette smoke has been shown lead vascular remodelling. Computed tomography (CT) imaging measures of pruning have associated with pulmonary disease, an important morbidity smoking. In this study we compare CT-based distal vessel loss histological and parenchymal changes. Methods A retrospective review 80 patients who had undergone lung resection identified appropriate for three-dimensional (3D) reconstruction (n=18) a second group two-dimensional (2D) analysis...
Cigarette smoking contributes to the risk of death through different mechanisms.
Multiple studies have demonstrated an increased risk of chronic obstructive pulmonary disease (COPD) in heterozygous carriers the AAT (alpha-1 antitrypsin) Z allele. However, it is not known if MZ subjects with COPD are phenotypically different from noncarriers (MM genotype) COPD.
Background CT is the standard method used to assess bronchiectasis. A higher airway-to-artery diameter ratio (AAR) typically identify enlarged bronchi and bronchiectasis; however, current imaging methods are limited in assessing extent of this metric scans. Purpose To determine AARs using an artificial intelligence–based chest association with exacerbations over time. Materials Methods In a secondary analysis ever-smokers from prospective, observational, multicenter COPDGene study, were...
Chronic obstructive pulmonary disease (COPD) and idiopathic fibrosis (IPF) are characterized by shared exposures clinical features, but distinct genetic pathologic features exist. These have not been well-studied using large-scale gene expression datasets. We hypothesized that there divergent gene, pathway, cellular signatures between COPD IPF.We performed RNA-sequencing on lung tissues from individuals with IPF (n = 231) 377) compared to control 267), defined as normal spirometry. grouped...
Thirty‐two patients suffering from migraine without aura were assessed during the interictal period to evaluate contribution of cytokines pathophysiology migraine. To this end, plasma levels IFN‐γ, IL‐4, IL‐5, and IL‐10 measured by enzyme‐linked immunosorbent assay (ELlSA) techniques. Plasma both IFN‐γ not increased in did differ significantly healthy controls. Of interest, we observed a strong increase IL‐5 84.3% as well IL‐4 37.5% with aura. These results suggest preferential enhancement...
Pulmonary hypertension is a heterogeneous disease, and significant portion of patients at risk for it have CT imaging available. Advanced automated processing techniques could be leveraged early detection, screening, development quantitative phenotypes. Pruning vascular tortuosity been previously described in pulmonary arterial (PAH), but the extent these phenomena vs venous vasculature exercise (ePH) not described.What are manifestations pruning using PAH, do they also occur ePH?A cohort...
The ability of peripheral blood biomarkers to assess chronic obstructive pulmonary disease (COPD) risk and progression is unknown. Genetics gene expression may capture important aspects COPD-related biology that predict activity.
Objectives Since pulmonary hypertension (PH) worsens the prognosis of idiopathic fibrosis (IPF), early prediction PH is crucial for timely intervention. This study aims to develop and validate a machine learning model predict using automated CT-based 3D measurements, particularly central cardiovascular structures, segmented by publicly available tool. Methods We retrospectively studied 163 IPF patients who underwent both thin-section chest CT (contrast-enhanced non-contrast) right heart...
Computed tomography (CT) helps physicians locate and diagnose pathological conditions. In some conditions, having an airway segmentation method which facilitates reconstruction of the from chest CT images can help hugely in assessment lung diseases. Many efforts have been made to develop algorithms, but methods are usually not optimized be reliable across different scan parameters. this paper, we present a simple semi-automatic algorithm segment tracheal bronchial anatomy using open-source...