Kim de Jong
A5026850316- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Pediatric health and respiratory diseases
- Air Quality and Health Impacts
- Epigenetics and DNA Methylation
- Respiratory and Cough-Related Research
- Neonatal Respiratory Health Research
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Lung Cancer Diagnosis and Treatment
- Glutathione Transferases and Polymorphisms
- Allergic Rhinitis and Sensitization
- Genetic Associations and Epidemiology
- Lung Cancer Treatments and Mutations
- Delphi Technique in Research
- Climate Change and Health Impacts
- Occupational exposure and asthma
- Fixed Point Theorems Analysis
- Tracheal and airway disorders
- Cavitation Phenomena in Pumps
- Energy and Environment Impacts
- Urban Green Space and Health
- IL-33, ST2, and ILC Pathways
- Urban Agriculture and Sustainability
Medisch Centrum Leeuwarden
2017-2025
Ruhr University Bochum
2024
Rheumazentrum Ruhrgebiet
2024
National Institute for Public Health and the Environment
2023
Migration Institute of Australia
2022
STMicroelectronics (France)
2022
Leiden University
2021
University Medical Center Groningen
2011-2020
University of Groningen
1990-2020
Institute for Asthma and Allergy
2018
Background: Long-term air pollution exposure is negatively associated with lung function, yet the mechanisms underlying this association are not fully clear. Differential DNA methylation may explain association. Objectives: Our main aim was to study between long-term and methylation. Methods: We performed a genome-wide using robust linear regression models in 1,017 subjects from LifeLines cohort analyze nitrogen dioxide ( NO2) particulate matter PM2.5, fine aerodynamic diameter ≤2.5μm; PM10,...
<h3>Objectives</h3> Occupational exposures are important and possibly modifiable contributors to the global burden of chronic obstructive pulmonary disease (COPD). Exposure vapours, gases, dusts fumes (VGDF) has been associated with a two- threefold higher COPD risk. Less is known about effects occupational exposure pesticides solvents. In current study, we assessed if VGDF, solvents level lung function prevalence airway obstruction in general population. <h3>Methods</h3> We included 11 851...
Objectives Occupational pesticide exposure is associated with a wide range of diseases, including lung but it largely unknown how pesticides influence airway disease pathogenesis. A potential mechanism might be through epigenetic mechanisms, like DNA methylation. Therefore, we assessed associations between occupational to and genome-wide methylation sites. Methods 1561 subjects LifeLines were included either no (n=1392), low (n=108) or high (n=61) any type (estimated based on current last...
Previous reports link differential DNA methylation (DNAme) to environmental exposures that are associated with lung function. Direct evidence on function DNAme is, however, limited. We undertook an agnostic epigenome-wide association study (EWAS) pre-bronchodilation and its change in adults. In a discovery–replication EWAS design, blood spirometry were measured twice, 6–15 years apart, the same participants of three adult population-based discovery cohorts (n=2043). Associated markers...
Abstract Background Most studies assessing health effects of neighborhood characteristics either use self-reports or objective assessments the environment, latter often based on Geographical Information Systems (GIS). While measures require detailed landscape data, self-assessments may yield confounded results. In this study we demonstrate how green environments aggregated to narrow area units serve as an appealing compromise between and individual self-assessments. Methods The uses...
Cross-sectional studies have shown that occupational exposure to vapors, gases, dusts, and fumes (VGDF) pesticides is associated with a lower level of lung function. These associations seem be stronger in ever smokers. In the current study, we aimed assess whether VGDF longitudinal decline We used 12,772 observations from 2,527 participants Vlagtwedde-Vlaardingen Study, general-population-based cohort study followed subjects for 25 years, 1965 last survey 1989/1990. Job-specific was...
Purpose: To examine the associations between residents' personality traits, type of specialty, and symptoms burnout.Method: A cross-sectional online survey among Dutch residents was conducted (see Supplementary Material). The 20-item translation Maslach Burnout Inventory used to ascertain burnout. Personality traits were assessed with 44-item Big Five Inventory. Logistic regression analyses, including all five assess Analyses stratified by specialties.Results: One thousand two hundred thirty...
Abstract Background Adherence to topical corticosteroids is low among atopic dermatitis patients and their parents. This can lead treatment failure decreased quality of life. Objective To assess compare the worries beliefs concerning parents children with dermatitis, involved health care professionals, between different professionals. Also, we identify factors associated corticosteroid phobia (corticophobia) in Methods Parents professionals were invited complete a questionnaire about...
Smoking is the strongest environmental risk factor for reduced pulmonary function. The genetic component of various traits has also been demonstrated, and at least 26 loci have reproducibly associated with either FEV 1 (forced expiratory volume in second) or /FVC (FEV /forced vital capacity). Although main effects smoking are well established, question potential gene-by-smoking interaction effect remains unanswered. aim present study was to assess, using a score approach, whether these on...
The Dutch national open database on COVID-19 has been incrementally expanded since its start 30 April 2020 and now includes datasets symptoms, tests performed, individual-level positive cases deaths, deaths among vulnerable populations, settings of transmission, hospital ICU admissions, SARS-CoV-2 variants, viral loads in sewage, vaccinations the effective reproduction number. This data is collected by municipal health services, laboratories, hospitals, sewage treatment plants, vaccination...
Surfactant protein D (SP-D) is produced primarily in the lung and involved regulating pulmonary surfactants, lipid homeostasis innate immunity. Circulating SP-D levels blood are associated with chronic obstructive disease (COPD), although causality remains elusive.In 4061 subjects COPD, we identified genetic variants serum levels. We then determined whether these affected tissue gene expression 1037 individuals. A Mendelian randomisation framework was applied, whereby SP-D-associated were...
Causal genes of chronic obstructive pulmonary disease (COPD) remain elusive. The current study aims at integrating genome-wide association studies (GWAS) and lung expression quantitative trait loci (eQTL) data to map COPD candidate causal gain biological insights into the recently discovered susceptibility loci. Two complementary genomic datasets on were studied. First, eQTL dataset which included whole-genome gene genotyping from 1038 individuals. Second, largest GWAS date International...
BackgroundPatients with severe asthma have been shown to low muscle mass, but the clinical consequences are unknown.ObjectiveIn a cohort of patients moderate asthma, we aimed assess mass and strength their relation functional outcomes, as well systemic inflammatory markers.MethodsMuscle were assessed by fat-free index (FFMI), creatinine excretion in 24-hour urine sample, handgrip test. Functional outcomes included pulmonary function tests 6-minute walking distance, whereas questionnaires on...
While many disease-associated single nucleotide polymorphisms (SNPs) are associated with gene expression (expression quantitative trait loci, eQTLs), a large proportion of complex disease genome-wide association study (GWAS) variants unknown function. Some these SNPs may contribute to by regulating splicing. Here, we investigate whether that alternative splicing (splice QTL or sQTL) can identify novel functions for existing GWAS suggest new in chronic obstructive pulmonary (COPD). RNA...
Introduction Dynamic hyperinflation has been documented in asthma, yet its impact on overall health and daily life activities is unclear. We assessed the prevalence of dynamic moderate to severe asthma relationship with scores a set specific general respiratory questionnaires. Methods 77 nonsmoking patients (Global Initiative for Asthma steps 4–5) were recruited consecutively completed five questionnaires: Control Questionnaire, Clinical COPD (chronic obstructive pulmonary disease) St...
Dietary factors have been suggested as drivers of the rising prevalence adult-onset asthma, but evidence is inconclusive, possibly due to complex interrelation with obesity. We aim explore relation diet quality and food intake incident asthma in normal weight overweight adults prospective population-based Lifelines Cohort Study.Incident was defined self-reported at ± 4-year follow-up, free airway disease baseline. Diet scores group were assessed Log-binomial regression analyses used estimate...