A5069219045- Animal Disease Management and Epidemiology
- COVID-19 epidemiological studies
- Vector-Borne Animal Diseases
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Immunology Research
- Vaccine Coverage and Hesitancy
- Influenza Virus Research Studies
- COVID-19 and Mental Health
- Viral gastroenteritis research and epidemiology
- Viral Infections and Vectors
- COVID-19 Pandemic Impacts
- Health disparities and outcomes
- SARS-CoV-2 detection and testing
- Yersinia bacterium, plague, ectoparasites research
- Bacillus and Francisella bacterial research
- Herpesvirus Infections and Treatments
- Microbial infections and disease research
- Poxvirus research and outbreaks
- COVID-19 Clinical Research Studies
- Human Mobility and Location-Based Analysis
- Data-Driven Disease Surveillance
- Animal Virus Infections Studies
- Respiratory viral infections research
- Privacy, Security, and Data Protection
- COVID-19 and healthcare impacts
National Institute for Public Health and the Environment
2015-2024
Health Forecasting
2020
Wageningen University & Research
2009-2018
International Crisis Group
2013-2014
A novel coronavirus (2019-nCoV) is causing an outbreak of viral pneumonia that started in Wuhan, China. Using the travel history and symptom onset 88 confirmed cases were detected outside Wuhan early phase, we estimate mean incubation period to be 6.4 days (95% credible interval: 5.6–7.7), ranging from 2.1 11.1 (2.5th 97.5th percentile). These values should help inform 2019-nCoV case definitions appropriate quarantine durations.
In May 2022, monkeypox outbreaks have been reported in countries not endemic for monkeypox. We estimated the incubation period, using exposure and symptom-onset times 18 cases detected confirmed Netherlands up to 31 2022. Mean period was 9.0 days* (5th–95th percentiles: 4.2–17.3), underpinning current recommendation monitor or isolate/quarantine case contacts 21 days. However, as may differ between different transmission routes, further epidemiological investigations are needed.
The SARS-CoV-2 Omicron variant has a growth advantage over the Delta because of higher transmissibility, immune evasion or shorter serial interval. Using S gene target failure (SGTF) as indication for BA.1, we identified 908 SGTF and 1,621 non-SGTF intervals in same period. Within households, mean interval cases was 0.2-0.6 days than cases. This suggests that is partly due to
Whole-genome sequencing of pathogens from host samples becomes more and routine during infectious disease outbreaks. These data provide information on possible transmission events which can be used for further epidemiologic analyses, such as identification risk factors infectivity transmission. However, the relationship between sequence is obscured by uncertainty arising four largely unobserved processes: transmission, case observation, within-host pathogen dynamics mutation. To properly...
BackgroundDuring the COVID-19 pandemic, many countries have implemented physical distancing measures to reduce transmission of SARS-CoV-2.AimTo measure actual reduction contacts when are implemented.MethodsA cross-sectional survey was carried out in Netherlands 2016-17, which participants reported number and age their previous day. The repeated among a subsample April 2020, after strict were implemented, an extended sample June some relaxed.ResultsThe average community per day reduced from...
We estimated SARS-CoV-2 vaccine effectiveness against onward transmission by comparing secondary attack rates among household members for vaccinated and unvaccinated index cases, based on source contact tracing data collected when the Delta variant was dominant. Effectiveness of full vaccination case to fully contacts, respectively, 63% (95% confidence interval (CI): 46–75) 40% CI: 20–54), in addition direct protection contacts infection.
Abstract Background SARS-CoV-2 dynamics are driven by human behaviour. Social contact data of utmost importance in the context transmission models close-contact infections. Methods Using online representative panels adults reporting on their own behaviour as well parents one children, we collect mixing (CoMix) various phases COVID-19 pandemic over 20 European countries. We provide these timely, repeated observations using an platform: SOCRATES-CoMix. In addition to providing cleaned datasets...
Estimating the differences in incubation-period, serial-interval, and generation-interval distributions of SARS-CoV-2 variants is critical to understanding their transmission. However, impact epidemic dynamics often neglected estimating timing infection—for example, when an growing exponentially, a cohort infected individuals who developed symptoms at same time are more likely have been recently. Here, we reanalyze incubation-period serial-interval data describing transmissions Delta Omicron...
Abstract This large, nationwide, population-based, seroepidemiological study provides evidence of the effectiveness physical distancing (>1.5 m) and indoor group size reductions in reducing severe acute respiratory syndrome coronavirus 2 infection. Additionally, young adults may play an important role viral spread, contrary to children up until age 12 years with whom close contact is permitted. Clinical Trials Registration NTR8473.
The COVID-19 pandemic was in 2020 and 2021 for a large part mitigated by reducing contacts the general population. To monitor how these changed over course of Netherlands, longitudinal survey conducted where participants reported on their at-risk every two weeks, as European CoMix survey. included 1659 from April to August 2514 December September 2021. We categorized number unique contacted persons excluding household members, per participant day into six activity levels, defined 0, 1, 2,...
Mpox has spread rapidly to many countries in nonendemic regions. After reviewing detailed exposure histories of 109 pairs mpox cases the Netherlands, we identified 34 where transmission was likely and infectee reported a single potential infector with mean serial interval 10.1 days (95% credible interval, 6.6-14.7 days). Further investigation into from 1 regional public health service revealed that presymptomatic may have occurred 5 18 pairs. These findings emphasize precaution remains key,...
The COVID-19 pandemic led to unprecedented changes in behaviour. To estimate if these persisted, a final round of the CoMix social contact survey was conducted four countries at time when all societal restrictions had been lifted for several months. We on nationally representative sample UK, Netherlands (NL), Belgium (BE), and Switzerland (CH). Participants were asked about their contacts behaviours previous day. calculated matrices compared levels pre-pandemic baseline R
Hepatitis E virus (HEV) genotype 3 and 4 can cause liver disease in human has its main reservoir pigs. HEV investigations pigs worldwide have been performed but there is still a lack of information on the infection dynamics pig populations.The transmission commercial farms six different European countries was studied. The data collected show prevalence weaners ranging from 8% to 30%. average growers between 20% 44%. fatteners ranged 73%. Sows similar all countries. Boar faeces were tested...
In a recent update of the Dutch contingency plan for controlling outbreaks classical swine fever (CSF), emergency vaccination is preferred to large-scale pre-emptive culling. This policy change raised two questions: can be as effective culling, and what are implications showing freedom infection? Here, we integrate quantitative information available on CSF virus transmission effects into stochastic mathematical model that describes dynamics at level animals, farms livestock areas. multilevel...
In 2014–2016, Guinea, Sierra Leone and Liberia in West Africa experienced the largest longest Ebola epidemic since discovery of virus 1976. During epidemic, incidence data were collected published at increasing resolution. To monitor as it spread within between districts, we develop an analysis method that exploits full spatiotemporal resolution by combining a local model for time-varying effective reproduction numbers with gravity-type spatial dispersion infection. We test this simulations...
Abstract Currently, a novel coronavirus 2019-nCoV causes an outbreak of viral pneumonia in Wuhan, China. Little is known about its epidemiological characteristics. Using the travel history and symptom onset 88 confirmed cases that were detected outside we estimate mean incubation period to be 6.4 (5.6 – 7.7, 95% CI) days, ranging from 2.1 11.1 days (2.5 th 97.5 percentile). These values help inform case definitions for appropriate durations quarantine.
The Dutch national open database on COVID-19 has been incrementally expanded since its start 30 April 2020 and now includes datasets symptoms, tests performed, individual-level positive cases deaths, deaths among vulnerable populations, settings of transmission, hospital ICU admissions, SARS-CoV-2 variants, viral loads in sewage, vaccinations the effective reproduction number. This data is collected by municipal health services, laboratories, hospitals, sewage treatment plants, vaccination...
SUMMARY Simulation models can offer valuable insights into the effectiveness of different control strategies and act as important decision support tools when comparing evaluating outbreak scenarios strategies. An international modelling study was performed to compare a range vaccination in foot-and-mouth disease (FMD). Modelling groups from five countries (Australia, New Zealand, USA, UK, The Netherlands) participated study. Vaccination is increasingly being recognized potentially tool FMD,...
Abstract The impact of COVID-19 on population health is recognised as being substantial, yet few studies have attempted to quantify what extent infection causes mild or moderate symptoms only, requires hospital and/or ICU admission, results in prolonged and chronic illness, leads premature death. We aimed the total disease burden acute Netherlands 2020 using disability-adjusted life-years (DALY) measure, investigate how varies between age-groups occupations. Using standard methods diverse...
African horse sickness (AHS) is an equine viral disease that spread by Culicoides spp. Since the closely related bluetongue established itself in The Netherlands 2006, AHS considered a potential threat for Dutch population. A vector-host model incorporates current knowledge of infection biology used to explore effect different parameters on whether and how will spread, assess control measures. time introduction important determinant depending temperature vector season. Given most favourable...
Hepatitis E is a viral disease that causes serious concerns for public health. virus (HEV) genotype 3 endemic in commercial pig farms worldwide act as reservoir. Pig-to-human transmission may occur when infectious animals enter the food chain at slaughter, through consumption of contaminated meat, direct exposure or use by-products. To reduce fraction slaughter age and thus risk health, it important to understand dynamics HEV populations. In this study, we estimate rate parameter mean period...
Between 2006 and 2009 the largest human Q fever epidemic ever described occurred in Netherlands. The source of infection was traced back to dairy goat herds with abortion problems due fever. first aim control measures taken these reduction exposure. To analyze dynamics study effect measures, a within-herd model Coxiella burnetii transmission developed. With this individual-based stochastic we evaluated six strategies three herd management styles studied which strategy leads lower prevalence...