A5014289730- Hepatitis B Virus Studies
- Hepatitis C virus research
- Hepatitis Viruses Studies and Epidemiology
- COVID-19 epidemiological studies
- Mosquito-borne diseases and control
- SARS-CoV-2 and COVID-19 Research
- Antifungal resistance and susceptibility
- Liver Disease Diagnosis and Treatment
- Vaccine Coverage and Hesitancy
- Respiratory viral infections research
- Poxvirus research and outbreaks
- Bacillus and Francisella bacterial research
- Viral Infections and Vectors
- HIV, Drug Use, Sexual Risk
- COVID-19 Digital Contact Tracing
- Water Treatment and Disinfection
- Vector-borne infectious diseases
- Insect symbiosis and bacterial influences
- Reproductive tract infections research
- Antimicrobial Resistance in Staphylococcus
- Infection Control in Healthcare
- Microbial infections and disease research
- Urinary Tract Infections Management
- Viral gastroenteritis research and epidemiology
- Influenza Virus Research Studies
Public Health Service of Amsterdam
2020-2024
Radboud University Medical Center
2012-2024
Radboud University Nijmegen
2012-2024
National Institute for Public Health and the Environment
2020-2023
Maastricht University
2016-2022
National Centre for Infectious Diseases
2022
Office of Infectious Diseases
2022
GGD West-Brabant
2012-2019
Maastricht University Medical Centre
2019
In October 2020, the first case of autochthonous West Nile virus neuroinvasive disease was diagnosed in Netherlands with a presumed infection last week August. Investigations revealed five more cases local (WNV) infection. The resided region where WNV detected bird and mosquitoes August 2020. Molecular analysis successful for two identified presence lineage 2.
Mpox has spread rapidly to many countries in nonendemic regions. After reviewing detailed exposure histories of 109 pairs mpox cases the Netherlands, we identified 34 where transmission was likely and infectee reported a single potential infector with mean serial interval 10.1 days (95% credible interval, 6.6-14.7 days). Further investigation into from 1 regional public health service revealed that presymptomatic may have occurred 5 18 pairs. These findings emphasize precaution remains key,...
Source and contact tracing (SCT) is a core public health measure that used to contain the spread of infectious diseases. It aims identify source infection, advise those who have been exposed this source. Due rapid increases in incidence COVID-19 Netherlands, capacity conduct full SCT quickly became insufficient. Therefore, services (PHS) might benefit from restricted strategy targeted geographical regions where (predicted) case-to-case transmission high. In study, we set out develop...
Abstract Background Day care centres (DCCs) are ideal settings for drug-resistant bacteria to emerge. Prevalence numbers of faecal carriage antimicrobial resistant in these rare. We aimed determine the prevalence children attending DCCs and assess identify infection risk factors within The Netherlands Belgium. Methods A point-prevalence study was conducted 28 Dutch (499 children) 18 Belgian (448 DCCs. Stool samples were taken from children’s diapers a questionnaire filled by their parents....
Wastewater treatment plants (WWTPs) are increasingly identified as Legionnaires’ disease (LD) sources. An outbreak investigation was initiated following five LD cases reported in September 2022 Houten, the Netherlands. Case identification based on European case definition, with symptom onset from 1 2022, residence or within 5 km of visit to Houten incubation period, without other likely We sampled potential sources and genotyped environmental clinical isolates. 15 between 13 23 October 2022....
BackgroundDifferential SARS-CoV-2 exposure between vaccinated and unvaccinated individuals may confound vaccine effectiveness (VE) estimates.AimWe conducted a test-negative case-control study to determine VE against infection the presence of confounding by exposure.MethodsWe included adults tested for at community facilities 4 July 8 December 2021 (circulation period Delta variant). The after primary vaccination with an mRNA (Comirnaty or Spikevax) vector-based (Vaxzevria Janssen) was...
SUMMARY We investigated the positive predictive value (PPV) of a solitary immunoglobulin M (IgM) phase II response for serodiagnosis acute Q fever detected with either an indirect immunofluorescence assay (IFA) or enzyme-linked immunosorbent (ELISA). Initial and follow-up sera from patients suspected were included if initially only IgM tested IFA in 2008 ( n =92), ELISA 2009 =85). A seroconversion was defined as initial sample being IgG negative but sample. The PPV isolated result by 65%...
Abstract Mpox has spread rapidly to many countries in non-endemic regions. After reviewing detailed exposure histories of 109 pairs mpox cases the Netherlands, we identified 34 where transmission was likely and infectee reported a single potential infector with mean serial interval 10.1 days (95% CI: 6.6–14.7 days). Pre-symptomatic may have occurred five out eighteen pairs. These findings emphasize that precaution remains key, regardless presence recognizable symptoms mpox.
To determine the longitudinal changes in viral load of hepatitis B virus (HBV)-infected healthcare workers (HCWs) and its consequences for exclusion infected HCWs performing exposure-prone procedures, various HBV DNA safety thresholds, frequency monitoring.Retrospective cohort study June 1, 1996-January 31, 2013. Participants In Netherlands, chronically HBV-infected procedures are notified to Committee Prevention Iatrogenic Hepatitis B. Of 126 HCWs, 45 had 2 or more levels determined without...
Abstract Background A tool, the Infection Risk Scan has been developed to measure quality of infection control and antimicrobial use. This tool measures various patient-, ward- care-related variables in a standardized way. We describe implementation this nine hospitals Dutch/Belgian border area obtained results. Methods The IRIS consists set objective reproducible measurements: patient comorbidities, (appropriate) use indwelling medical devices, therapy, rectal carriage Extended-spectrum...
SARS-CoV-2 prevention measures impact the circulation of other respiratory viruses. Surveillance in network general practitioners is hampered by widespread testing for public facilities.To evaluate integrated community surveillance and viruses describe epidemiological trends.Respiratory was set up within an existing facility. Community-dwelling (a)symptomatic persons provided consent completion a questionnaire additional on residual material from swabs taken RT-PCR (Allplex Seegene). Daily,...
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The detection of low levels antibodies against HBsAg (anti-HBs) below 10 IU/L in non-responders after a primary hepatitis B vaccination, is associated with seroconversion revaccination. We compared the diagnostic performance four anti-HBs assays their ability to differentiate between absence or presence and propose revaccination strategy guided by titres.Non-responders were revaccinated Fendrix 20 μg at 0, 1 2 months. Anti-HBs titres determined Abbott Architect, Diasorin Liaison, Roche Cobas...
Objectives Case finding is one of the priority actions to reduce disease burden chronic hepatitis B (CHB). We estimated contribution CHB case at sexual health centres (SHCs) total national number newly diagnosed cases in Netherlands and determined characteristics detected SHCs. Methods This observational study used surveillance data from all outpatient SHCs (SOAP database) notification (Osiris) 2008 2016. The proportion notifications (hepatitis surface antigen positive serology) was...
Abstract During 6 weeks in February–March 2021, the Dutch municipal health service Utrecht studied epidemiological effects on test incidence and detection of acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with mass testing (MT). MT, inhabitants Bunschoten could repeatedly regardless symptoms as often desired at close-by facilities municipality. Data from regular COVID-19 registration was used for analysis. In Bunschoten, MT caused a significant increase an immediate number detected...