Leo‐Pekka Lyytikäinen

ORCID: 0000-0002-7200-5455
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Research Areas
  • Genetic Associations and Epidemiology
  • Birth, Development, and Health
  • Nutrition, Genetics, and Disease
  • Cardiac electrophysiology and arrhythmias
  • Adipokines, Inflammation, and Metabolic Diseases
  • Epigenetics and DNA Methylation
  • RNA modifications and cancer
  • Cardiovascular Function and Risk Factors
  • Lipoproteins and Cardiovascular Health
  • Adipose Tissue and Metabolism
  • Atherosclerosis and Cardiovascular Diseases
  • Cancer-related molecular mechanisms research
  • Lipid metabolism and disorders
  • Genetic Mapping and Diversity in Plants and Animals
  • Metabolomics and Mass Spectrometry Studies
  • Heart Rate Variability and Autonomic Control
  • Diabetes, Cardiovascular Risks, and Lipoproteins
  • Bioinformatics and Genomic Networks
  • Obesity, Physical Activity, Diet
  • Blood groups and transfusion
  • Regulation of Appetite and Obesity
  • Atrial Fibrillation Management and Outcomes
  • Cardiac Arrhythmias and Treatments
  • Health, Environment, Cognitive Aging
  • Chronic Kidney Disease and Diabetes

Tampere University
2016-2025

Tampere University Hospital
2016-2025

Fimlab (Finland)
2015-2024

Cardiovascular Research Center
2018-2024

Pirkanmaa Hospital District
2010-2021

UK Biobank
2021

University of Rochester Medical Center
2021

Faculty of Public Health
2019

Netherlands Heart Institute
2019

University of the West Indies System
2019

Cristen J. Willer Ellen M. Schmidt Sebanti Sengupta Gina M. Peloso Stefan Gustafsson and 95 more Stavroula Kanoni Andrea Ganna Ming‐Huei Chen Martin L. Buchkovich Samia Mora J. Beckmann Jennifer L. Bragg‐Gresham Hsing‐Yi Chang Ayşe Demirkan Heleen M. den Hertog Ron Do Louise A. Donnelly Georg Ehret Tõnu Esko Mary F. Feitosa Teresa Ferreira Krista Fischer Pierre Fontanillas Ross M. Fraser Daniel F. Freitag Deepti Gurdasani Kauko Heikkilä Elina Hyppönen Aaron Isaacs Anne Jackson Åsa Johansson Toby Johnson Marika Kaakinen Johannes Kettunen Marcus E. Kleber Xiaohui Li Jian’an Luan Leo‐Pekka Lyytikäinen Patrik K. E. Magnusson Massimo Mangino Evelin Mihailov May E. Montasser Martina Müller‐Nurasyid Ilja M. Nolte Jeffrey R. O’Connell Cameron D. Palmer Markus Perola Ann-Kristin Petersen Serena Sanna Richa Saxena Susan K. Service Sonia Shah Dmitry Shungin Carlo Sidore Ci Song Rona J. Strawbridge Ida Surakka Toshiko Tanaka Tanya M. Teslovich Guðmar Þorleifsson Evita G. van den Herik Benjamin F. Voight Kelly A. Volcik Lindsay L. Waite Andrew Wong Ying Wu Weihua Zhang Devin Absher Gershim Asiki Inês Barroso Latonya Been Jennifer L. Bolton Lori L. Bonnycastle Paolo Brambilla Mary Susan Burnett Giancarlo Cesana Maria Dimitriou Alex S. F. Doney Angela Döring Paul Elliott Stephen E. Epstein Guðmundur I. Eyjólfsson Bruna Gigante Mark O. Goodarzi Harald Grallert Martha L. Gravito Christopher J. Groves Göran Hallmans Anna-Liisa Hartikainen Caroline Hayward Dena Hernández Andrew A. Hicks Hilma Hólm Yi-Jen Hung Thomas Illig Michelle R. Jones Pontiano Kaleebu John J.P. Kastelein Kay‐Tee Khaw Eric H. Kim

10.1038/ng.2797 article EN Nature Genetics 2013-10-06
Panos Deloukas Stavroula Kanoni Christina Willenborg Martin Farrall Themistocles L. Assimes and 95 more John R. Thompson Erik Ingelsson Danish Saleheen Jeanette Erdmann Benjamin A. Goldstein Kathleen Stirrups Inke R. König Jean‐Baptiste Cazier Åsa Johansson Alistair S. Hall Jong‐Young Lee Cristen J. Willer John C. Chambers Tõnu Esko Lasse Folkersen Anuj Goel Elin Grundberg Aki S. Havulinna Weang-Kee Ho Jemma C. Hopewell Niclas Eriksson Marcus E. Kleber Kati Kristiansson Per Lundmark Leo‐Pekka Lyytikäinen Suzanne Rafelt Dmitry Shungin Rona J. Strawbridge Guðmar Þorleifsson Emmi Tikkanen Natalie Van Zuydam Benjamin F. Voight Lindsay L. Waite Weihua Zhang Andreas Ziegler Devin Absher David Altshuler Anthony J. Balmforth Inês Barroso Peter S. Braund Christof Burgdorf Xueling Sim David Cox Maria Dimitriou Ron Do Alex S. F. Doney NourEddine El Mokhtari Per Eriksson Krista Fischer Pierre Fontanillas Anders Franco‐Cereceda Bruna Gigante Per‐Henrik Groop Stefan Gustafsson Jörg Hager Göran Hallmans Bok-Ghee Han Sarah Hunt Hyun Min Kang Thomas Illig Thorsten Kessler Joshua Knowles Genovefa Kolovou Johanna Kuusisto Claudia Langenberg Cordelia Langford Karin Leander Marja‐Liisa Lokki Anders Lundmark Mark I. McCarthy Christa Meisinger Olle Melander Evelin Mihailov Seraya Maouche Andrew D. Morris Martina Müller‐Nurasyid Kjell Nikus John F. Peden Nigel W. Rayner Asif Rasheed Silke Rosinger Deborah C. Rubin Moritz Rumpf Arne Schäfer Mohan U. Sivananthan Ci Song Alexandre F.R. Stewart Sian-Tsung Tan Guðmundur Þorgeirsson C. Ellen van der Schoot Peter J. Wagner George A. Wells Philipp S. Wild Tsun-Po Yang Philippe Amouyel

10.1038/ng.2480 article EN Nature Genetics 2012-12-02
Ron Do Cristen J. Willer Ellen M. Schmidt Sebanti Sengupta Chi Gao and 95 more Gina M. Peloso Stefan Gustafsson Stavroula Kanoni Andrea Ganna Jin Chen Martin L. Buchkovich Samia Mora J. Beckmann Jennifer L. Bragg‐Gresham Hsing‐Yi Chang Ayşe Demirkan Heleen M. den Hertog Louise A. Donnelly Georg Ehret Tõnu Esko Mary F. Feitosa Teresa Ferreira Krista Fischer Pierre Fontanillas Ross M. Fraser Daniel F. Freitag Deepti Gurdasani Kauko Heikkilä Elina Hyppönen Aaron Isaacs Anne Jackson Åsa Johansson Toby Johnson Marika Kaakinen Johannes Kettunen Marcus E. Kleber Xiaohui Li Jian’an Luan Leo‐Pekka Lyytikäinen Patrik K. E. Magnusson Massimo Mangino Evelin Mihailov May E. Montasser Martina Müller‐Nurasyid Ilja M. Nolte Jeffrey R. O’Connell Colin N. A. Palmer Markus Perola Ann-Kristin Petersen Serena Sanna Richa Saxena Susan K. Service Sonia Shah Dmitry Shungin Carlo Sidore Ci Song Rona J. Strawbridge Ida Surakka Toshiko Tanaka Tanya M. Teslovich Guðmar Þorleifsson Evita G. van den Herik Benjamin F. Voight Kelly A. Volcik Lindsay L. Waite Andrew Wong Ying Wu Weihua Zhang Devin Absher Gershim Asiki Inês Barroso Latonya Been Jennifer L. Bolton Lori L. Bonnycastle Paolo Brambilla Mary Susan Burnett Giancarlo Cesana Maria Dimitriou Alex S. F. Doney Angela Döring Paul Elliott Stephen E. Epstein Guðmundur I. Eyjólfsson Bruna Gigante Mark O. Goodarzi Harald Grallert Martha L. Gravito Christopher J. Groves Göran Hallmans Anna-Liisa Hartikainen Caroline Hayward Dena Hernandez Andrew A. Hicks Hilma Hólm Yi-Jen Hung Thomas Illig Michelle R. Jones Pontiano Kaleebu John J.P. Kastelein Kay‐Tee Khaw

10.1038/ng.2795 article EN Nature Genetics 2013-10-06

Genome-wide association studies have identified numerous loci linked with complex diseases, for which the molecular mechanisms remain largely unclear. Comprehensive profiling of circulating metabolites captures highly heritable traits, can help to uncover metabolic pathophysiology underlying established disease variants. We conduct an extended genome-wide study genetic influences on 123 traits quantified by nuclear magnetic resonance metabolomics from up 24,925 individuals and identify eight...

10.1038/ncomms11122 article EN cc-by Nature Communications 2016-03-23
Paolo Zanoni Sumeet A. Khetarpal Daniel B. Larach William Hancock‐Cerutti John S. Millar and 95 more Marina Cuchel Stephanie DerOhannessian Anatol Kontush Praveen Surendran Danish Saleheen Stella Trompet J. Wouter Jukema Anton de Craen Panos Deloukas Naveed Sattar Ian Ford Chris J. Packard Abdullah Al Shafi Majumder Dewan S Alam Emanuele Di Angelantonio Gonçalo R. Abecasis Rajiv Chowdhury Jeanette Erdmann Børge G. Nordestgaard Sune F. Nielsen Anne Tybjærg‐Hansen Ruth Frikke‐Schmidt Kari Kuulasmaa Dajiang J. Liu Markus Perola Stefan Blankenberg Veikko Salomaa Satu Männistö Philippe Amouyel Dominique Arveiler Jean Ferrières Martina Müller‐Nurasyid Maurizio Ferrario Frank Kee Cristen J. Willer Nilesh J. Samani Heribert Schunkert Adam S. Butterworth Joanna M. M. Howson Gina M. Peloso Nathan O. Stitziel John Danesh Sekar Kathiresan Daniel J. Rader Sarah Watson Ellen M. Schmidt Sebanti Sengupta Stefan Gustafsson Stavroula Kanoni Andrea Ganna Ming‐Huei Chen Martin L. Buchkovich Samia Mora J. Beckmann Jennifer L. Bragg‐Gresham Hsing‐Yi Chang Ayşe Demirkan Heleen M. den Hertog Ron Do Louise A. Donnelly Georg Ehret Tõnu Esko Mary F. Feitosa Teresa Ferreira Krista Fischer Pierre Fontanillas Ross M. Fraser Daniel F. Freitag Deepti Gurdasani Kauko Heikkilä Elina Hyppönen Aaron Isaacs Anne Jackson Åsa Johansson Toby Johnson Marika Kaakinen Johannes Kettunen Marcus E. Kleber Xiaohui Li Jian’an Luan Leo‐Pekka Lyytikäinen Patrik K. E. Magnusson Massimo Mangino Evelin Mihailov May E. Montasser Ilja M. Nolte Jeffrey R. O’Connell Colin N. A. Palmer Ann-Kristin Petersen Serena Sanna Richa Saxena Susan K. Service Sonia Shah Dmitry Shungin Carlo Sidore

A scavenger that protects the heart Coronary disease is a tale of two forms plasma cholesterol. In contrast to well-established effects “bad” cholesterol (LDL-C), role “good” (HDL-C) mysterious. Elevated HDL-C correlates with lower risk disease, yet drugs raise levels do not reduce risk. Zanoni et al. found some people exceptionally high carry rare sequence variant in gene encoding major receptor, receptor BI. This destroys receptor's ability take up HDL-C. Interestingly, this have higher...

10.1126/science.aad3517 article EN Science 2016-03-10
Xia Jiang Paul F. O’Reilly Hugues Aschard Yi-Hsiang Hsu J. Brent Richards and 95 more Josée Dupuis Erik Ingelsson David Karasik Stefan Pilz Diane J. Berry Bryan Kestenbaum Ju‐Sheng Zheng Jian’an Luan Eleni Sofianopoulou Elizabeth A. Streeten Demetrius Albanes Pamela L. Lutsey Lu Yao Weihong Tang Michael J. Econs Henri Wallaschofski Henry Völzke Ang Zhou Chris Power Mark I. McCarthy Erin D. Michos Eric Boerwinkle Stephanie J. Weinstein Neal D. Freedman Wen‐Yi Huang Natasja M. van Schoor Nathalie van der Velde C.P.G.M. de Groot Anke W. Enneman L. Adrienne Cupples Sarah L. Booth Ramachandran S. Vasan Yongmei Liu Yanhua Zhou Samuli Ripatti Claes Ohlsson Liesbeth Vandenput Mattias Lorentzon Johan G. Eriksson M. Kyla Shea Denise K. Houston Stephen B. Kritchevsky Yongmei Liu Kurt K. Lohman Luigi Ferrucci Munro Peacock Christian Gieger Marian Beekman P. Eline Slagboom Joris Deelen Diana van Heemst Marcus E. Kleber Winfried März Ian H. de Boer Alexis C. Wood Jerome I. Rotter Stephen S. Rich Cassianne Robinson‐Cohen Martin den Heijer Marjo‐Riitta Järvelin Alana Cavadino Peter K. Joshi James F. Wilson Caroline Hayward Lars Lind Karl Michaëlsson Stella Trompet M. Carola Zillikens André G. Uitterlinden Fernando Rivadeneira Linda Broer Lina Zgaga Harry Campbell Evropi Τheodoratou Susan M. Farrington Maria Timofeeva Malcolm G. Dunlop Ana M. Valdes Emmi Tikkanen Terho Lehtimäki Leo‐Pekka Lyytikäinen Mika Kähönen Olli T. Raitakari Vera Mikkilä M. Arfan Ikram Naveed Sattar J. Wouter Jukema Nicholas J. Wareham Claudia Langenberg Nita G. Forouhi Thomas E. Gundersen Kay‐Tee Khaw Adam S. Butterworth John Danesh Timothy D. Spector

Vitamin D is a steroid hormone precursor that associated with range of human traits and diseases. Previous GWAS serum 25-hydroxyvitamin concentrations have identified four genome-wide significant loci (GC, NADSYN1/DHCR7, CYP2R1, CYP24A1). In this study, we expand the previous SUNLIGHT Consortium discovery sample size from 16,125 to 79,366 (all European descent). This larger yields two additional harboring variants (P = 4.7×10

10.1038/s41467-017-02662-2 article EN cc-by Nature Communications 2018-01-11
Norihiro Kato Marie Loh Fumihiko Takeuchi Niek Verweij Xu Wang and 95 more Weihua Zhang Tanika N Kelly Danish Saleheen Benjamin Lehne Irene Mateo Leach Alexander Drong James Abbott Simone Wahl Sian-Tsung Tan William R. Scott Gianluca Campanella Marc Chadeau‐Hyam Uzma Afzal Tarunveer S. Ahluwalia Marc Jan Bonder Peng Chen Abbas Dehghan Todd L. Edwards Tõnu Esko Min Jin Go Sarah E. Harris Jaana Hartiala Silva Kasela Anuradhani Kasturiratne Chiea Chuen Khor Marcus E. Kleber Huaixing Li Zuan Yu Mok Masahiro Nakatochi Nur Sabrina Sapari Richa Saxena Alexandre F.R. Stewart Lisette Stolk Yasuharu Tabara Ai Ling Teh Ying Wu Jer-Yuarn Wu Yi Zhang Imke Aits Alexessander Couto Alves Shikta Das Rajkumar Dorajoo Jemma C Hopewell Yun Kyoung Kim Robert W Koivula Jian’an Luan Leo‐Pekka Lyytikäinen Quang N Nguyen Mark A. Pereira Iris Postmus Olli T Raitakari Molly Scannell Bryan Robert A. Scott Rossella Sorice Vinicius Tragante Michela Traglia Jon White Ken Yamamoto Yonghong Zhang Linda S. Adair Alauddin Ahmed Koichi Akiyama Rasheed Asif Tin Aung Inês Barroso Andrew Bjonnes Timothy R. Braun Hui Cai Li-Ching Chang Chien‐Hsiun Chen Ching‐Yu Cheng Yap Seng Chong Rory Collins Regina Courtney Gail Davies Graciela Delgado Loi D. Pieter A. Doevendans Ron T. Gansevoort Yu-Tang Gao Tanja B. Grammer Niels Grarup Jagvir Grewal Dongfeng Gu Gurpreet S Wander Anna-Liisa Hartikainen Stanley L. Hazen Jing He Chew‐Kiat Heng James E. Hixson Albert Hofman Chris Hsu Wei Huang Lise Lotte N. Husemoen Joo‐Yeon Hwang

10.1038/ng.3405 article EN Nature Genetics 2015-09-21
Pim van der Harst Weihua Zhang Irene Mateo Leach Augusto Rendon Niek Verweij and 95 more Joban Sehmi Dirk S. Paul Ulrich Elling Hooman Allayee Man Li Aparna Radhakrishnan Sian-Tsung Tan Katrin Voß Christian X. Weichenberger Cornelis A. Albers Abtehale Al-Hussani Folkert W. Asselbergs Marina Ciullo Fabrice Danjou Christian Dina Tõnu Esko David M. Evans Lude Franke Martin Gögele Jaana Hartiala Micha Hersch Hilma Hólm Jouke‐Jan Hottenga Stavroula Kanoni Marcus E. Kleber Vasiliki Lagou Claudia Langenberg Lorna M. Lopez Leo‐Pekka Lyytikäinen Olle Melander Federico Murgia Ilja M. Nolte Paul F. O’Reilly Sandosh Padmanabhan Afshin Parsa Nicola Pirastu Eleonora Porcu Laura Portas Inga Prokopenko Janina S. Ried So-Youn Shin Clara Sze-Man Tang Alexander Teumer Michela Traglia Sheila Ulivi Harm-Jan Westra Jian Yang Wei Zhao Franco Anni Abdel Abdellaoui Antony Attwood Beverley Balkau Stefania Bandinelli François Bastardot Beben Benyamin Bernhard O. Boehm William Cookson Debashish Das Paul I. W. de Bakker Rudolf A. de Boer Eco J. C. de Geus Marleen H. M. de Moor Maria Dimitriou Francisco S. Domingues Angela Döring Gunnar Engström Guðmundur I. Eyjólfsson Luigi Ferrucci Krista Fischer Renzo Galanello Stephen F. Garner Bernd Genser Quince Gibson Giorgia Girotto Daníel F. Guðbjartsson Sarah E. Harris Anna-Liisa Hartikainen Claire E. Hastie Bo Hedblad Thomas Illig Jennifer Jolley Mika Kähönen Ido P. Kema John P. Kemp Liming Liang Heather Lloyd-Jones Ruth J. F. Loos Stuart Meacham Sarah E. Medland Christa Meisinger Yasin Memari Evelin Mihailov Kathy Ann Miller Miriam F. Moffatt Matthias Nauck

10.1038/nature11677 article EN Nature 2012-12-01
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