Leo‐Pekka Lyytikäinen
- Genetic Associations and Epidemiology
- Birth, Development, and Health
- Nutrition, Genetics, and Disease
- Cardiac electrophysiology and arrhythmias
- Adipokines, Inflammation, and Metabolic Diseases
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Cardiovascular Function and Risk Factors
- Lipoproteins and Cardiovascular Health
- Adipose Tissue and Metabolism
- Atherosclerosis and Cardiovascular Diseases
- Cancer-related molecular mechanisms research
- Lipid metabolism and disorders
- Genetic Mapping and Diversity in Plants and Animals
- Metabolomics and Mass Spectrometry Studies
- Heart Rate Variability and Autonomic Control
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Bioinformatics and Genomic Networks
- Obesity, Physical Activity, Diet
- Blood groups and transfusion
- Regulation of Appetite and Obesity
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Health, Environment, Cognitive Aging
- Chronic Kidney Disease and Diabetes
Tampere University
2016-2025
Tampere University Hospital
2016-2025
Fimlab (Finland)
2015-2024
Cardiovascular Research Center
2018-2024
Pirkanmaa Hospital District
2010-2021
UK Biobank
2021
University of Rochester Medical Center
2021
Faculty of Public Health
2019
Netherlands Heart Institute
2019
University of the West Indies System
2019
Genome-wide association studies have identified numerous loci linked with complex diseases, for which the molecular mechanisms remain largely unclear. Comprehensive profiling of circulating metabolites captures highly heritable traits, can help to uncover metabolic pathophysiology underlying established disease variants. We conduct an extended genome-wide study genetic influences on 123 traits quantified by nuclear magnetic resonance metabolomics from up 24,925 individuals and identify eight...
A scavenger that protects the heart Coronary disease is a tale of two forms plasma cholesterol. In contrast to well-established effects “bad” cholesterol (LDL-C), role “good” (HDL-C) mysterious. Elevated HDL-C correlates with lower risk disease, yet drugs raise levels do not reduce risk. Zanoni et al. found some people exceptionally high carry rare sequence variant in gene encoding major receptor, receptor BI. This destroys receptor's ability take up HDL-C. Interestingly, this have higher...
Vitamin D is a steroid hormone precursor that associated with range of human traits and diseases. Previous GWAS serum 25-hydroxyvitamin concentrations have identified four genome-wide significant loci (GC, NADSYN1/DHCR7, CYP2R1, CYP24A1). In this study, we expand the previous SUNLIGHT Consortium discovery sample size from 16,125 to 79,366 (all European descent). This larger yields two additional harboring variants (P = 4.7×10