M. Carola Zillikens
A5067726769- Bone health and osteoporosis research
- Genetic Associations and Epidemiology
- Bone health and treatments
- Nutrition, Genetics, and Disease
- Vitamin D Research Studies
- Parathyroid Disorders and Treatments
- Nutrition and Health in Aging
- Bone Metabolism and Diseases
- Bone and Joint Diseases
- Advanced Glycation End Products research
- Adipose Tissue and Metabolism
- Connective tissue disorders research
- Folate and B Vitamins Research
- Genetic Mapping and Diversity in Plants and Animals
- Diet and metabolism studies
- Hip and Femur Fractures
- Genetic Syndromes and Imprinting
- Genetic and phenotypic traits in livestock
- Nutritional Studies and Diet
- RNA modifications and cancer
- Genetics and Physical Performance
- Medical Imaging and Pathology Studies
- Obesity, Physical Activity, Diet
- Magnesium in Health and Disease
- Regulation of Appetite and Obesity
Erasmus MC
2016-2025
Erasmus University Rotterdam
2015-2024
University Medical Center
2024
Society of Nuclear Medicine and Molecular Imaging
2023
ERN BOND
2022
ERN GUARD-Heart
2022
Netherlands Consortium for Healthy Ageing
2010-2018
John Wiley & Sons (United Kingdom)
2018
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2018
Massachusetts General Hospital
2018
Given the anthropometric differences between men and women previous evidence of sex-difference in genetic effects, we conducted a genome-wide search for sexually dimorphic associations with height, weight, body mass index, waist circumference, hip waist-to-hip-ratio (133,723 individuals) took forward 348 SNPs into follow-up (additional 137,052 total 94 studies. Seven loci displayed significant (FDR<5%), including four previously established (near GRB14/COBLL1, LYPLAL1/SLC30A10, VEGFA,...
Vitamin D is a steroid hormone precursor that associated with range of human traits and diseases. Previous GWAS serum 25-hydroxyvitamin concentrations have identified four genome-wide significant loci (GC, NADSYN1/DHCR7, CYP2R1, CYP24A1). In this study, we expand the previous SUNLIGHT Consortium discovery sample size from 16,125 to 79,366 (all European descent). This larger yields two additional harboring variants (P = 4.7×10
Individuals with type 2 diabetes have increased fracture risk despite higher bone mineral density (BMD). Our aim was to examine the influence of glucose control on skeletal complications.Data 4,135 participants Rotterdam Study, a prospective population-based cohort, were available (mean follow-up 12.2 years). At baseline, 420 classified by (according HbA1c calculated from fructosamine), resulting in three comparison groups: adequately controlled (ACD; n = 203; <7.5%), inadequately (ICD; 217;...
Central abdominal fat is a strong risk factor for diabetes and cardiovascular disease. To identify common variants influencing central fat, we conducted two-stage genome-wide association analysis waist circumference (WC). In total, three loci reached significance. stage 1, 31,373 individuals of Caucasian descent from eight cohort studies confirmed the role FTO MC4R identified one novel locus associated with WC in neurexin 3 gene [NRXN3 (rs10146997, p = 6.4x10(-7))]. The NRXN3 was 2 by...
Abstract Recent studies suggest that mild hyponatremia is associated with fractures, but prospective are lacking. We studied whether falls, and/or bone mineral density (BMD). A total of 5208 elderly subjects serum sodium assessed at baseline were included from the population-based Rotterdam Study. The following data analyzed: BMD, vertebral fractures (mean follow-up 6.4 years), nonvertebral (7.4 recent comorbidity, medication, and mortality. Hyponatremia was detected in 399 (7.7%, 133.4 ±...
The role of estrogens in ischemic heart disease (IHD) is uncertain. Evidence suggests that genetic variations the estrogen receptor alpha (ESR1) gene may influence IHD risk, but common sequence ESR1 unclear.To determine whether haplotype created by c.454-397T>C (PvuII) and c.454-351A>G (XbaI) polymorphisms associated with myocardial infarction (MI) risk.In 2617 men 3791 postmenopausal women from Rotterdam Study (enrollment between 1989-1993 follow-up to January 2000), a population-based,...
Osteoporosis is a complex disorder and commonly leads to fractures in elderly persons. Genome-wide association studies (GWAS) have become an unbiased approach identify variations the genome that potentially affect health. However, genetic variants identified so far only explain small proportion of heritability for traits. Due modest effect size inadequate power, true signals may not be revealed based on stringent genome-wide significance threshold. Here, we take advantage SNP transcript...
Plastin 3 (PLS3), a protein involved in the formation of filamentous actin (F-actin) bundles, appears to be important human bone health, on basis pathogenic variants PLS3 five families with X-linked osteoporosis and osteoporotic fractures that we report here. The bone-regulatory properties were supported by vivo analyses zebrafish. Furthermore, an additional (described less detail) referred for diagnosis or ruling out osteogenesis imperfecta type I, rare variant (rs140121121) was found. This...