Philippa J. Talmud
A5007875460- Diabetes, Cardiovascular Risks, and Lipoproteins
- Lipoproteins and Cardiovascular Health
- Genetic Associations and Epidemiology
- Lipid metabolism and disorders
- Cancer, Lipids, and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Cholesterol and Lipid Metabolism
- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Liver Disease Diagnosis and Treatment
- Lipid metabolism and biosynthesis
- Nutrition, Genetics, and Disease
- Bioinformatics and Genomic Networks
- Cardiovascular Function and Risk Factors
- Biomedical Text Mining and Ontologies
- Blood Coagulation and Thrombosis Mechanisms
- Atherosclerosis and Cardiovascular Diseases
- Renin-Angiotensin System Studies
- Diet, Metabolism, and Disease
- Cancer-related molecular mechanisms research
- Hormonal Regulation and Hypertension
- Folate and B Vitamins Research
- Blood properties and coagulation
- Diabetes and associated disorders
- Protease and Inhibitor Mechanisms
University College London
2009-2019
University of Oxford
2015-2018
Queen Mary University of London
1997-2018
University of Cambridge
2008-2018
European Bioinformatics Institute
2018
Medical College of Wisconsin
2018
Phoenix Bioinformatics
2018
University of Oregon
2018
Jackson Laboratory
2018
University of Bristol
2010-2017
The Gene Ontology (GO) Consortium (GOC, http://www.geneontology.org) is a community-based bioinformatics resource that classifies gene product function through the use of structured, controlled vocabularies. Over past year, GOC has implemented several processes to increase quantity, quality and specificity GO annotations. First, number manual, literature-based annotations grown at an increasing rate. Second, as result new 'phylogenetic annotation' process, manually reviewed, homology-based...
Abstract. There is abundant evidence that the risk of atherosclerotic vascular disease directly related to plasma cholesterol levels. Accordingly, all national and transnational screening therapeutic guidelines are based on total or LDL cholesterol. This presumes most important lipoprotein‐related proatherogenic variable. On contrary, appears be more number circulating atherogenic particles contact enter arterial wall than measured concentration in these lipoprotein fractions. Each contains...
<b>Objectives</b> To assess the performance of a panel common single nucleotide polymorphisms (genotypes) associated with type 2 diabetes in distinguishing incident cases future (discrimination), and to examine effect adding genetic information previously validated non-genetic (phenotype based) models developed estimate absolute risk diabetes. <b>Design</b> Workplace based prospective cohort study three 5 yearly medical screenings. <b>Participants</b> 5535 initially healthy people (mean age...
Abstract BACKGROUND Familial hypercholesterolemia (FH) is an autosomal-dominant disorder caused by mutations in 1 of 3 genes. In the 60% patients who are mutation negative, we have recently shown that clinical phenotype can be associated with accumulation common small-effect LDL cholesterol (LDL-C)-raising alleles use a 12–single nucleotide polymorphism (12-SNP) score. The aims study were to improve selection SNPs and replicate results additional samples. METHODS We used ROC curves determine...
Since triglycerides (TG) are a major independent risk factor for coronary heart disease, understanding their genetic and environmental determinants is of importance. Mouse models indicate an inverse relationship between levels the newly identified apolipoprotein AV (APOAV) TG concentrations. We have examined relative influence human APOA5 variants on plasma lipids, compared to impact variation in APOC3 APOA4 which lie same cluster. Single nucleotide polymorphisms (SNPs) (S19W, -1131T>C)...
Background The absence (deletion allele [ D ]) of a 287–base pair marker in the ACE gene is associated with higher levels than its presence (insertion I ]). If renin-angiotensin systems regulate left ventricular (LV) growth, then individuals DD genotype might show greater hypertrophic response those II genotype. We tested this hypothesis by studying exercise-induced LV hypertrophy. Methods and Results Echocardiographically determined dimensions mass (n=140), electrocardiographically...
Objective— The Apolipoprotein-related Mortality Risk (AMORIS) study concluded that the apolipoprotein (apo)B/apoA-I ratio was best predictor of coronary heart disease (CHD) risk. We have compared pairwise combinations total cholesterol, triglycerides (TGs), apoB, high density lipoprotein (HDL) low and apoA-I on CHD risk prediction in middle–aged men. Methods Results— Healthy middle-aged men (n=2508), free at baseline, were examined prospectively. Over 6 years follow-up, there 163 events...
The study assessed the efficacy of fish oil supplementation in counteracting classic dyslipidemia atherogenic lipoprotein phenotype (ALP). In addition, impact common apolipoprotein E (apoE) polymorphism on fasting and postprandial lipid profile responsiveness to dietary intervention was established. Fifty-five ALP males (aged 34 69 years, body mass index 22 35 kg/m(2), triglyceride [TG] levels 1.5 4.0 mmol/L, high density cholesterol [HDL-C] <1.1 mmol/l, percent low [LDL]-3 >40% total LDL)...
The Gene Ontology (GO) (http://www.geneontology.org) is a community bioinformatics resource that represents gene product function through the use of structured, controlled vocabularies. number GO annotations products has increased due to curation efforts among Consortium (GOC) groups, including focused literature-based annotation and ortholog-based functional inference. ontologies continue expand improve as result targeted ontology development, introduction computable logical definitions...