A5090498118- Lipoproteins and Cardiovascular Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiac Imaging and Diagnostics
- Cardiac Valve Diseases and Treatments
- Cancer, Lipids, and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Function and Risk Factors
- Cardiovascular Effects of Exercise
- Atherosclerosis and Cardiovascular Diseases
- Infective Endocarditis Diagnosis and Management
- Advanced MRI Techniques and Applications
- Congenital Heart Disease Studies
- Health Systems, Economic Evaluations, Quality of Life
- Cardiovascular Disease and Adiposity
- Genetic Associations and Epidemiology
- Lipid metabolism and disorders
- Cardiovascular Health and Risk Factors
- Cardiac Arrhythmias and Treatments
- Blood Pressure and Hypertension Studies
- Atrial Fibrillation Management and Outcomes
- Cholesterol and Lipid Metabolism
- Cardiac Health and Mental Health
- Antiplatelet Therapy and Cardiovascular Diseases
- Aortic Disease and Treatment Approaches
- Nutritional Studies and Diet
Amsterdam University Medical Centers
2018-2025
Vrije Universiteit Amsterdam
2025
Amsterdam UMC Location University of Amsterdam
2015-2024
University of Amsterdam
2015-2024
Amsterdam Neuroscience
2021-2023
GGD Amsterdam
2019-2023
OLVG
2022
Health & Safety in Sports
2022
Sport Medisch Centrum Papendal
2022
Vrije Universiteit Brussel
2022
<h3>Context</h3>The value of assessing various emerging lipid-related markers for prediction first cardiovascular events is debated.<h3>Objective</h3>To determine whether adding information on apolipoprotein B and A-I, lipoprotein(a), or lipoprotein-associated phospholipase A<sub>2</sub> to total cholesterol high-density lipoprotein (HDL-C) improves disease (CVD) risk prediction.<h3>Design, Setting, Participants</h3>Individual records were available 165 544 participants without baseline CVD...
Body fat distribution has been cross-sectionally associated with atherosclerotic disease risk factors, but the prospective relation coronary heart remains uncertain.We examined between indices and among 24,508 men women 45 to 79 years of age using proportional hazards regression. During a mean 9.1 follow-up, 1708 892 developed disease. The for developing subsequent increased continuously across range waist-hip ratio. Hazard ratios (95% CI) top versus bottom fifth ratio were 1.55 (1.28 1.73)...
Low-density lipoprotein (LDL) cholesterol is the principal target of lipid-lowering therapy, but recent evidence has suggested more appropriate targets. We compared relationships on-treatment levels LDL cholesterol, non-high-density (HDL) and apolipoprotein B, as well ratios total/HDL LDL/HDL B/A-I, with occurrence cardiovascular events in patients receiving statin therapy.A post hoc analysis was performed that combined data from 2 prospective, randomized clinical trials which 10,001...
<h2>Summary</h2><h3>Background</h3> Although HDL cholesterol concentrations are strongly and inversely associated with risk of coronary heart disease, interventions that raise do not reduce disease. efflux capacity—a prototypical measure function—has been disease after adjusting for cholesterol, but its effect on incident is uncertain. <h3>Methods</h3> We measured capacity assessed relation vascular factors events in a nested case-control sample from the prospective EPIC-Norfolk study 25 639...
Genetic studies might provide new insights into the biological mechanisms underlying lipid metabolism and risk of CAD. We therefore conducted a genome-wide association study to identify novel genetic determinants low-density lipoprotein cholesterol (LDL-C), high-density (HDL-C), triglycerides.We combined data from 8 studies, comprising up 17 723 participants with information on circulating concentrations. did independent replication in 37 774 populations also population Indian Asian descent....
Atherosclerotic cardiovascular disease is the most important public health problem of our time in both Europe and rest world, accounting for greatest expenditure healthcare budgets. Achieving consistency clinical care, incorporating new evidence their synthesis into practical recommendations clinicians task various guideline committees throughout world. Any change a set guidelines therefore can have far reaching consequences, particularly if they appear to be at variance with existing...
Although a previous study has suggested that genetic variant in the LPA region was associated with presence of aortic valve stenosis (AVS), no prospective role for lipoprotein(a) levels pathophysiology AVS. Our objective to determine whether and common is strongly are an increased risk developing AVS.Serum were measured 17 553 participants European Prospective Investigation into Cancer (EPIC)-Norfolk study. Among these participants, 118 developed AVS during mean follow-up 11.7 years. The...
Lipoprotein(a) [Lp(a)], a major carrier of oxidized phospholipids (OxPL), is associated with an increased incidence aortic stenosis (AS). However, it remains unclear whether elevated Lp(a) and OxPL drive disease progression are therefore targets for therapeutic intervention.This study investigated on apolipoprotein B-100 (OxPL-apoB) levels activity, progression, clinical events in AS patients, along the mechanisms underlying any associations.This combined 2 prospective cohorts measured...
Abstract Aim Lipoprotein(a) [Lp(a)] is a potential causal factor in the pathogenesis of aortic valve disease. However, relationship Lp(a) with new onset and progression calcium (AVC) has not been studied. The purpose study was to assess whether high serum levels are associated AVC incidence progression. Methods results A total 922 individuals from population-based Rotterdam Study (mean age 66.0±4.2 years, 47.7% men), whose measurements were available, underwent non-enhanced cardiac computed...
Background— The novel anticoagulant fondaparinux proved to be effective and safe in the postoperative prevention of venous thrombosis. Current phase III trials with this synthetic selective factor Xa inhibitor focus on its use treatment patients arterial As any therapy, there is a risk bleeding complications; hence, strategy reverse effects desirable. aim study was investigate whether recombinant VIIa (rFVIIa) could neutralize subcutaneously administered fondaparinux. Methods Results— In...