A5060603669- Lipoproteins and Cardiovascular Health
- Coronary Interventions and Diagnostics
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Genetic Associations and Epidemiology
- Antiplatelet Therapy and Cardiovascular Diseases
- Epigenetics and DNA Methylation
- Telomeres, Telomerase, and Senescence
- Adipokines, Inflammation, and Metabolic Diseases
- Growth Hormone and Insulin-like Growth Factors
- Liver Disease Diagnosis and Treatment
- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- Lipid metabolism and disorders
- Cardiac Valve Diseases and Treatments
- Nutritional Studies and Diet
- vaccines and immunoinformatics approaches
- Immunotherapy and Immune Responses
- Acute Myocardial Infarction Research
- Diabetes and associated disorders
- Advanced Causal Inference Techniques
- HIV-related health complications and treatments
- Birth, Development, and Health
- Cancer-related molecular mechanisms research
- Child Nutrition and Water Access
- Iron Metabolism and Disorders
The University of Texas Medical Branch at Galveston
2025
UC Irvine Health
2025
Imperial College London
2021-2023
Hospital Kuala Lumpur
2023
Wellcome Sanger Institute
2010-2021
The Priory Hospital
2021
University of Cambridge
2004-2019
Artemis Hospitals
2014-2019
Uganda Virus Research Institute
2013-2017
Artemis (United States)
2015
<h3>Context</h3>The value of assessing various emerging lipid-related markers for prediction first cardiovascular events is debated.<h3>Objective</h3>To determine whether adding information on apolipoprotein B and A-I, lipoprotein(a), or lipoprotein-associated phospholipase A<sub>2</sub> to total cholesterol high-density lipoprotein (HDL-C) improves disease (CVD) risk prediction.<h3>Design, Setting, Participants</h3>Individual records were available 165 544 participants without baseline CVD...
Abstract The poor transferability of genetic risk scores (GRSs) derived from European ancestry data in diverse populations is a cause concern. We set out to evaluate whether GRSs African American individuals and multiancestry perform better sub-Saharan Africa (SSA) compared ancestry-derived scores. Using summary statistics the Million Veteran Program (MVP), we showed that enhance polygenic prediction lipid traits SSA However, our GRS varied greatly within between South Zulu (low-density...
Experimental and observational studies in humans animals suggest that insulin-like growth factor 1 (IGF1) its principal binding protein, IGFBP3, may influence breast cancer susceptibility. We have examined the association of nine four single nucleotide polymorphisms (SNPs) IGF1 gene IGFBP3 genes, respectively, with circulating levels their products a population-based study 600 middle-aged men women, case-control study, comprised 4647 cases 4564 controls. All participants are from East...
Background: An elevated apolipoprotein B–apolipoprotein A-I (apo B–apo A-I) ratio is a risk factor for future coronary artery disease (CAD). It not known whether this better than traditional lipid values assessment and prediction it adds predictive value to the Framingham score. Objective: To evaluate apo associated with CAD events independent of measurements score ability predict occurrence CAD. Design: Prospective, nested case–control study. Setting: Norfolk, United Kingdom. Participants:...
Abstract Previous studies have reported that shorter mean telomere length in lymphocytes was associated with increased susceptibility to common diseases of aging, and may be predictive cancer risk. However, most analyses examined retrospectively collected case-control studies. Mean measured using high-throughput quantitative real-time PCR. Blood for DNA extraction after diagnosis the East Anglian SEARCH Breast (2,243 cases 2,181 controls) Colorectal (2,249 2,161 Prospective were conducted...
The General Population Cohort (GPC) was set up in 1989 to examine trends HIV prevalence and incidence, their determinants rural south-western Uganda. Recently, the research questions have included epidemiology genetics of communicable non-communicable diseases (NCDs) address limited data on burden risk factors for NCDs sub-Saharan Africa. cohort comprises all residents (52% aged ≥13years, men women equal proportions) within one-half a sub-county, residing scattered houses, largely farmers...
The imprinted insulin-like growth factor 2 (IGF2) gene is expressed predominantly from the paternal allele. Loss of imprinting (LOI) associated with hypomethylation at promoter proximal sequence (DMR0) IGF2 was proposed as a predisposing constitutive risk biomarker for colorectal cancer. We used pyrosequencing to assess whether DMR0 methylation either present constitutively prior cancer or it acquired tissue-specifically after onset DNA samples tumour tissues and matched non-tumour 22 breast...
To study the prospective relationship between serum levels of type II secretory phospholipase A2 (sPLA2) and risk future coronary artery disease (CAD) in apparently healthy men women.We conducted a nested case-control among women aged 45 to 79 years. Cases (n=1105) were people whom fatal or nonfatal CAD developed during follow-up. Controls (n=2209) matched by age, sex, enrollment time. sPLA2 significantly higher cases than controls (9.5 ng/mL; interquartile range [IQR], 6.4 14.8 versus 8.3...
<h3>Objective:</h3> To evaluate the role of inflammatory biomarkers C-reactive protein (CRP), myeloperoxidase, paraoxonase, secretory phospholipase A2 group IIA (sPLA2), lipoprotein-associated A2, fibrinogen, macrophage chemoattractant protein-1 and adiponectin, in predicting risk coronary heart disease (CHD) among people estimated to be at intermediate according Framingham Risk Score (FRS). <h3>Design:</h3> Prospective case–control study nested EPIC-Norfolk cohort. <h3>Setting:</h3>...
Objective Glycated haemoglobin (HbA1c) is recommended as an additional tool to glucose-based measures (fasting plasma glucose [FPG] and 2-hour [2PG] during oral tolerance test [OGTT]) for the diagnosis of diabetes; however, its use in sub-Saharan African populations not established. We assessed prevalence estimates detection diabetes based on OGTT, FPG, HbA1c urban black South population. Research Design Methods conducted a population-based cross-sectional survey using multistage cluster...
ABSTRACT Background Higher physical activity (PA) is associated with better neuropsychiatric health, but prior studies have been limited by cross‐sectional designs, self‐reported PA measures, and small numbers of older individuals. We examined associations between baseline changes in accelerometer‐measured moderate‐vigorous (MVPA) health among individuals aged ≥ 70 years the National Health Aging Trends Study. Methods used average daily minutes MVPA above a validated threshold 2184 counts...
Abstract Iron is an essential trace element for both humans and pathogens, but its genetic determinants are understudied in Africa where iron deficiency infectious diseases highly prevalent. We conducted genome-wide association studies six iron-related biomarkers 3928 children from five sites across with replication 2868 African American adults. identify a previously unreported loci transferrin GTF3C5, gene regulating cellular iron-uptake, soluble receptor FREM3 , the Dantu locus, hepcidin...
Low plasma levels of IGF-I, particularly when coupled with low the potentially inhibitory IGF binding protein (IGFBP)-1 and higher C-reactive (CRP), have been implicated in pathogenesis metabolic syndrome X cardiovascular disease. We report relative contributions IGFBP-1 CRP to occurrence a healthy population cohort establish extent which these factors may contribute subsequent risk disease.The volunteers study were all participants Ely study, continuing population-based Ely, Cambridgeshire,...
Objectives To evaluate, in the FLEX Registry, clinical outcomes of an ultrathin (60 µm) biodegradable polymer-coated Supraflex sirolimus-eluting stent (SES) for treatment coronary artery disease. Additionally, to determine vascular response SES through optical coherence tomography (OCT) analysis. Setting Multicentre, single-arm, all-comers, observational registry patients who were treated with SES, between July 2013 and May 2014, at nine different centres India. Participants 995 (1242...
Omega-3 fatty acids, especially alpha-linolenic acid (ALA), which are present in nuts may reduce cardiovascular disease (CVD) risk, by changing vascular inflammation and improving endothelial dysfunction. The objective of the study was to evaluate acute effects two different diets, one containing walnuts other almonds on function. Twenty-seven overweight volunteers underwent a randomized 2-period, crossover, controlled intervention study. subjects were given either walnut or almond diets...
Abstract Joint fine-mapping that leverages information between quantitative traits could improve accuracy and resolution over single-trait fine-mapping. Using summary statistics, flashfm (flexible shared fine-mapping) fine-maps signals for multiple traits, allowing missing trait measurements use of related individuals. In a Bayesian framework, prior model probabilities are formulated to favour combinations share causal variants capitalise on traits. Simulation studies demonstrate both...