A5074687621- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes Management and Research
- Diabetes and associated disorders
- Genetic Associations and Epidemiology
- Diabetes Treatment and Management
- Pancreatic function and diabetes
- Liver Disease Diagnosis and Treatment
- HIV-related health complications and treatments
- Cardiovascular Function and Risk Factors
- Obesity, Physical Activity, Diet
- Cancer-related molecular mechanisms research
- HIV/AIDS Research and Interventions
- T-cell and B-cell Immunology
- Pituitary Gland Disorders and Treatments
- Diet and metabolism studies
- Parathyroid Disorders and Treatments
- RNA modifications and cancer
- HIV Research and Treatment
- Pancreatitis Pathology and Treatment
- Global Public Health Policies and Epidemiology
- Genetics, Bioinformatics, and Biomedical Research
- Muscle metabolism and nutrition
- Chronic Disease Management Strategies
- Lipoproteins and Cardiovascular Health
- Epigenetics and DNA Methylation
University of KwaZulu-Natal
2015-2024
London School of Hygiene & Tropical Medicine
2023
Uganda Virus Research Institute
2023
University of Cape Town
2013-2023
Icahn School of Medicine at Mount Sinai
2023
Research Network (United States)
2020
Southeastern University
2015
Nova Southeastern University
2015
Florida State University
2015
University of the Witwatersrand
2013
Given the importance of Africa to studies human origins and disease susceptibility, detailed characterization African genetic diversity is needed. The Genome Variation Project provides a resource with which design, implement interpret genomic in sub-Saharan worldwide. represents dense genotypes from 1,481 individuals whole-genome sequences 320 across Africa. Using this resource, we find novel evidence complex, regionally distinct hunter-gatherer Eurasian admixture We identify new loci under...
With population ageing worldwide, dementia poses one of the greatest global challenges for health and social care in 21st century. In 2019, around 55 million people were affected by dementia, with majority living low- middle-income countries. Dementia leads to increased costs governments, communities, families individuals. is overwhelming family caregivers person who are cornerstone support systems throughout world. To assist countries addressing burden World Health Organisation (WHO)...
Abstract The poor transferability of genetic risk scores (GRSs) derived from European ancestry data in diverse populations is a cause concern. We set out to evaluate whether GRSs African American individuals and multiancestry perform better sub-Saharan Africa (SSA) compared ancestry-derived scores. Using summary statistics the Million Veteran Program (MVP), we showed that enhance polygenic prediction lipid traits SSA However, our GRS varied greatly within between South Zulu (low-density...
To determine the prevalence of metabolic syndrome and to define optimal ethnic-specific waist-circumference cutoff points in a rural South African black community.This was cross-sectional survey conducted by random-cluster sampling adults aged >15 years. Participants had demographic, anthropometric, biochemical measurements taken, including 75-g oral glucose tolerance test. Metabolic defined using 2009 Joint Interim Statement (JIS) definition.Of 947 subjects (758 women) studied, age-adjusted...
The purpose of this study was to determine the prevalence diabetes, impaired glucose tolerance (IGT), fasting glycemia (IFG), and associated risk factors in a rural South African black community.This cross-sectional survey conducted by random cluster sampling adults aged >15 years. Participants had 75-g oral test using 1998 World Health Organization criteria for disorders glycemia.Of 1,300 subjects selected, 1,025 (815 women) participated (response rate 78.9%). overall age-adjusted diabetes...
Genome-wide association studies (GWAS) for type 2 diabetes have uncovered >400 risk loci, primarily in populations of European and Asian ancestry. Here, we aimed to discover additional loci (including African-specific variants) fine-map signals by performing genetic analysis African populations. We conducted two genome-wide 4347 Africans from South Africa, Nigeria, Ghana Kenya meta-analysed both together. Likely causal variants were identified using fine-mapping approaches. The most...
Hypertension and obesity are the most important modifiable risk factors for cardiovascular diseases, but their association is not well characterized in Africa. We investigated regional patterns of with hypertension among 30 044 continental Africans. harmonized data on (defined as previous diagnosis/use antihypertensive drugs or blood pressure [BP]≥140/90 mmHg/BP≥130/80 mmHg) from individuals Cardiovascular H3Africa Innovation Resource across 13 African countries. analyzed population-based...
Until recently, there was a paucity of data on the epidemiology diabetes mellitus in Africa. Over past decade, information prevalence type 2 has increased, albeit still limited, but is lack adequate 1 sub-Saharan Africa (SSA). For diabetes, although low some rural populations, moderate and even high rates have been reported from other countries. In to impaired glucose tolerance possible indicator early stage epidemic. Diabetes higher urban, migrant African-origin populations living abroad....
OBJECTIVE To determine the prevalence of diabetes mellitus and impaired glucose tolerance (IGT) to test for bimodality in plasma distribution South African Indians. RESEARCH DESIGN AND METHODS Subjects were selected by systematic cluster sampling various areas Durban. They underwent a modified whereby fasting 2-h postglucose (75 g) levels measured. The program MIX was used distribution. RESULTS We tested 2,479 subjects (1,441 women 1,038 men). Based on revised World Health Organization...
Waist circumference (WC) thresholds derived from western populations continue to be used in sub-Saharan Africa (SSA) despite increasing evidence of ethnic variation the association between adiposity and cardiometabolic disease availability data African populations. We aimed derive a SSA-specific optimal WC cut-point for identifying individuals at increased risk.
Existing electronic data capture options are often financially unfeasible in resource-poor settings or difficult to support technically the field. To help facilitate large-scale multicenter studies sub-Saharan Africa, African Partnership for Chronic Disease Research (APCDR) has developed an open-source questionnaire (EQ).To assess its relative validity, we compared EQ against traditional pen-and-paper methods using 200 randomized interviews conducted ongoing type 2 diabetes case-control...