Eric J. Brunner
A5037452603- Health disparities and outcomes
- Nutritional Studies and Diet
- Obesity, Physical Activity, Diet
- School Choice and Performance
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Employment and Welfare Studies
- Diet and metabolism studies
- Dementia and Cognitive Impairment Research
- Workplace Health and Well-being
- Global Health Care Issues
- Blood Pressure and Hypertension Studies
- Fiscal Policy and Economic Growth
- Cardiovascular Health and Disease Prevention
- Cardiac Health and Mental Health
- Housing Market and Economics
- Urban, Neighborhood, and Segregation Studies
- Physical Activity and Health
- Health Promotion and Cardiovascular Prevention
- Chronic Disease Management Strategies
- Consumer Attitudes and Food Labeling
- Health, psychology, and well-being
- Adipokines, Inflammation, and Metabolic Diseases
- Health Systems, Economic Evaluations, Quality of Life
- Birth, Development, and Health
- Nutrition and Health in Aging
University of Connecticut
2015-2025
University College London
2016-2025
Klinik Donaustauf
2025
The University of Texas Southwestern Medical Center
2025
Connecticut Department of Public Health
2021-2024
Otsuka (United States)
2024
Lundbeck (United States)
2021-2023
Deerfield (United States)
2021-2023
Idaho National Laboratory
2023
National Bureau of Economic Research
2008-2022
<h3>Abstract</h3> <b>Objectives</b> To investigate the association between stress at work and metabolic syndrome. <b>Design</b> Prospective cohort study investigating <b>Participants</b> 10 308 men women, aged 35-55, employed in 20 London civil service departments baseline (the Whitehall II study); follow-up was an average of 14 years. <b>Main outcome measures</b> Work based on iso-strain model, measured four occasions (1985-99). Biological measures syndrome, National Cholesterol Education...
There is debate about the value of assessing levels C-reactive protein (CRP) and other biomarkers inflammation for prediction first cardiovascular events.We analyzed data from 52 prospective studies that included 246,669 participants without a history disease to investigate adding CRP or fibrinogen conventional risk factors risk. We calculated measures discrimination reclassification during follow-up modeled clinical implications initiation statin therapy after assessment fibrinogen.The...
<h3>Context</h3>Previous studies may have underestimated the contribution of health behaviors to social inequalities in mortality because were assessed only at baseline study.<h3>Objective</h3>To examine role association between socioeconomic position and compare whether their differs when 1 point time with that longitudinally through follow-up period.<h3>Design, Setting, Participants</h3>Established 1985, British Whitehall II longitudinal cohort study includes 10 308 civil servants, aged 35...
Abstract Aims The aim of this study was to develop, validate, and illustrate an updated prediction model (SCORE2) estimate 10-year fatal non-fatal cardiovascular disease (CVD) risk in individuals without previous CVD or diabetes aged 40–69 years Europe. Methods results We derived models using individual-participant data from 45 cohorts 13 countries (677 684 individuals, 30 121 events). used sex-specific competing risk-adjusted models, including age, smoking status, systolic blood pressure,...
To determine the association between adverse psychosocial characteristics at work and risk of coronary heart disease among male female civil servants.Prospective cohort study (Whitehall II study). At baseline examination (1985-8) twice during follow up a self report questionnaire provided information on factors environment disease. Independent assessments were obtained from personnel managers baseline. Mean length was 5.3 years.London based office staff in 20 service departments.10,308...
To help adapt cardiovascular disease risk prediction approaches to low-income and middle-income countries, WHO has convened an effort develop, evaluate, illustrate revised models. Here, we report the derivation, validation, illustration of charts that have been adapted circumstances 21 global regions.
<h3>Importance</h3> The prevalence of cardiometabolic multimorbidity is increasing. <h3>Objective</h3> To estimate reductions in life expectancy associated with multimorbidity. <h3>Design, Setting, and Participants</h3> Age- sex-adjusted mortality rates hazard ratios (HRs) were calculated using individual participant data from the Emerging Risk Factors Collaboration (689 300 participants; 91 cohorts; years baseline surveys: 1960-2007; latest follow-up: April 2013; 128 843 deaths). HRs...
The Whitehall studies have come to be closely associated with the investigation of socioeconomic differences in physical and mental illness mortality: social gradient.1,2 That was not initial purpose first study. Donald Reid Geoffrey Rose set up Whitehall, 1960s, as a kind British Framingham:3 ‘Framingham’ insofar it longitudinal study cardiorespiratory disease diabetes, looking at individual risk factors for disease; ‘British’ that done on cheap—a simple screening examination follow-up...
To determine the biological and behavioural factors linking work stress with coronary heart disease (CHD).A total of 10 308 London-based male female civil servants aged 35-55 at phase 1 (1985-88) Whitehall II study were studied. Exposures included (assessed phases 2), outcomes risk (phase 3), metabolic syndrome rate variability, morning rise in cortisol 7), incident CHD (phases 2-7) on basis death, non-fatal myocardial infarction, or definite angina. Chronic was associated this association...
Background Studies of diet and depression have focused primarily on individual nutrients. Aims To examine the association between dietary patterns using an overall approach. Method Analyses were carried data from 3486 participants (26.2% women, mean age 55.6 years) Whitehall II prospective cohort, in which two identified: ‘whole food’ (heavily loaded by vegetables, fruits fish) ‘processed sweetened desserts, fried food, processed meat, refined grains high-fat dairy products). Self-reported...
Background A lack of longitudinal studies has made it difficult to establish the direction associations between circulating concentrations low-grade chronic inflammatory markers, such as C-reactive protein and interleukin-6, cognitive symptoms depression. The present study sought assess whether interleukin-6 predict depression or these markers. Method In a prospective occupational cohort British white-collar civil servants (the Whitehall II study), serum protein, were measured at baseline in...
Socioeconomic disadvantage is a risk factor for many diseases. We characterised cascades of these conditions by using data-driven approach to examine the association between socioeconomic status and temporal sequences in development 56 common diseases health conditions.In this multi-cohort study, we used data from two Finnish prospective cohort studies: Health Social Support study Public Sector study. Our pooled primary analysis comprised 109 246 adults aged 17-77 years at entry. captured...
Background— The causes of metabolic syndrome (MS), which may be a precursor coronary disease, are uncertain. We hypothesize that disturbances in neuroendocrine and cardiac autonomic activity (CAA) contribute to development MS. examine reversibility the power psychosocial behavioral factors explain adaptations accompany Methods Results— This was double-blind case-control study working men aged 45 63 years drawn from Whitehall II cohort. MS cases (n=30) were compared with healthy controls...
Although overweight and obesity have been studied in relation to individual cardiometabolic diseases, their association with risk of multimorbidity is poorly understood. Here we aimed establish the incident (ie, at least two from: type 2 diabetes, coronary heart disease, stroke) adults who are obese compared those a healthy weight.
<h3>Context</h3>The value of assessing various emerging lipid-related markers for prediction first cardiovascular events is debated.<h3>Objective</h3>To determine whether adding information on apolipoprotein B and A-I, lipoprotein(a), or lipoprotein-associated phospholipase A<sub>2</sub> to total cholesterol high-density lipoprotein (HDL-C) improves disease (CVD) risk prediction.<h3>Design, Setting, Participants</h3>Individual records were available 165 544 participants without baseline CVD...
Although sleep curtailment has become widespread in industrialised societies, little work examined the effects on mortality of change duration. We investigated associations duration and with all-cause, cardiovascular, non-cardiovascular mortality. Prospective cohort study. Data are from baseline (Phase 1, 1985–88) Phase 3 (1991–93), follow-up 17 12 years respectively. The Whitehall II study 10,308 white-collar British civil servants aged 35–55 at baseline. 9,781 participants complete data...