A5070026765- Dementia and Cognitive Impairment Research
- Health disparities and outcomes
- Obesity, Physical Activity, Diet
- Physical Activity and Health
- Nutritional Studies and Diet
- Frailty in Older Adults
- Nutrition and Health in Aging
- Sleep and related disorders
- Alzheimer's disease research and treatments
- Diet and metabolism studies
- Blood Pressure and Hypertension Studies
- Health Systems, Economic Evaluations, Quality of Life
- Chronic Disease Management Strategies
- Cardiovascular Health and Risk Factors
- Birth, Development, and Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Health, Environment, Cognitive Aging
- Aging, Elder Care, and Social Issues
- Acute Ischemic Stroke Management
- Aging and Gerontology Research
- Sleep and Wakefulness Research
- Alcohol Consumption and Health Effects
- Balance, Gait, and Falls Prevention
- Health and Wellbeing Research
- Cardiac Health and Mental Health
Inserm
2016-2025
Université Paris Cité
2019-2025
University College London
2016-2025
Sorbonne Paris Cité
2019-2025
Centre de Recherche Épidémiologie et Statistique
2019-2024
Hôtel-Dieu de Paris
2021-2024
Institut Droit et Santé
2024
Université Paris-Saclay
2008-2023
University of Tasmania
2023
Faculty (United Kingdom)
2023
<h3>Context</h3>Previous studies may have underestimated the contribution of health behaviors to social inequalities in mortality because were assessed only at baseline study.<h3>Objective</h3>To examine role association between socioeconomic position and compare whether their differs when 1 point time with that longitudinally through follow-up period.<h3>Design, Setting, Participants</h3>Established 1985, British Whitehall II longitudinal cohort study includes 10 308 civil servants, aged 35...
Recent technological advances have transformed the research on physical activity initially based questionnaire data to most recent objective from accelerometers. The shift availability of raw accelerations has increased measurement accuracy, transparency, and potential for harmonization. However, it also shifted need considerable processing expertise researcher. Many users do not this expertise. R package GGIR been made available all as a tool convermulti-day high resolution accelerometer...
Wrist-worn accelerometers are increasingly being used for the assessment of physical activity in population studies, but little is known about their value sleep assessment. We developed a novel method assessing duration using data from 4,094 Whitehall II Study (United Kingdom, 2012–2013) participants aged 60–83 who wore accelerometer 9 consecutive days, filled log and reported via questionnaire. Our detection algorithm defined (nocturnal) as period sustained inactivity, itself detected...
Neuropsychiatric symptoms, depressive symptoms in particular, are common patients with dementia but whether adulthood increases the risk for remains subject of debate.To characterize trajectory over 28 years prior to diagnosis determine carry dementia.Up 10 308 persons, aged 35 55 years, were recruited Whitehall II cohort study 1985, end follow-up 2015. Data analysis this a UK general community was conducted from October December 2016.Depressive assessed on 9 occasions between 1985 and 2012...
Sleep dysregulation is a feature of dementia but it remains unclear whether sleep duration prior to old age associated with incidence. Using data from 7959 participants the Whitehall II study, we examined association between and incidence (521 diagnosed cases) using 25-year follow-up. Here report higher risk six hours or less at 50 60, compared normal (7 h) duration, although this was imprecisely estimated for 70 (hazard ratios (HR) 1.22 (95% confidence interval 1.01-1.48), 1.37 (1.10-1.72),...
Abstract Wrist worn raw-data accelerometers are used increasingly in large-scale population research. We examined whether sleep parameters can be estimated from these data the absence of diaries. Our heuristic algorithm uses variance z-axis angle and makes basic assumptions about interruptions. Detected period time window (SPT-window) was compared against diary 3752 participants (range = 60–82 years) polysomnography clinic patients (N 28) healthy good sleepers 22). The SPT-window derived...
<h3>Abstract</h3> <h3>Objective</h3> To test the hypotheses that physical activity in midlife is not associated with a reduced risk of dementia and preclinical phase characterised by decline activity. <h3>Design</h3> Prospective cohort study mean follow-up 27 years. <h3>Setting</h3> Civil service departments London (Whitehall II study). <h3>Participants</h3> 10 308 participants aged 35-55 years at inception (1985-88). Exposures included time spent mild, moderate to vigorous, total assessed...
Differences in morbidity and mortality between socioeconomic groups constitute one of the most consistent findings epidemiologic research. However, research on social inequalities health has yet to provide a comprehensive understanding mechanisms underlying this association. In recent analysis, we showed behaviours, assessed longitudinally over follow-up, explain major proportion association status (SES) with British Whitehall II study. whether behaviours are equally important mediators...
We examined whether obesity at ages 50, 60, and 70 years is associated with subsequent dementia. Changes in body mass index (BMI) for more than 28 before dementia diagnosis were compared changes BMI those free of dementia.A total 10,308 adults (33% women) aged 35 to 55 1985 followed up until 2015. was assessed six times 329 cases recorded.Obesity (BMI ≥30 kg/m2) age 50 (hazard ratio = 1.93; 1.35-2.75) but not 60 or risk Trajectories differed all others (P < .0001) matched control subjects...
The correlation between objective and self-reported measures of physical activity varies studies. We examined this association whether it differed by demographic factors or socioeconomic status (SES). Data were from 3,975 Whitehall II (United Kingdom, 2012–2013) participants aged 60–83 years, who completed a questionnaire wore an accelerometer on their wrist for 9 days. There was moderate questionnaire- accelerometer-assessed (Spearman's r = 0.33, 95% confidence interval: 0.30, 0.36)....
Abstract Sleep is an essential human function but its regulation poorly understood. Using accelerometer data from 85,670 UK Biobank participants, we perform a genome-wide association study of 8 derived sleep traits representing quality, quantity and timing, validate our findings in 5,819 individuals. We identify 47 genetic associations at P < 5 × 10 −8 , which 20 reach stricter threshold −10 . These include 26 novel with measures quality nocturnal duration. The majority identified...
Background— Inflammatory processes are putative mechanisms underlying the cardioprotective effects of physical activity. An inverse association between activity and inflammation has been demonstrated, but no long-term prospective data available. We therefore examined inflammatory markers over a 10-year follow-up period. Methods Results— Participants were 4289 men women (mean age, 49.2 years) from Whitehall II cohort study. Self-reported (serum high-sensitivity C-reactive protein...
<h3>Importance</h3> Trends in type 2 diabetes show an increase prevalence along with younger age of onset. While vascular complications early-onset are known, the associations dementia remains unclear. <h3>Objective</h3> To determine whether at onset is more strongly associated incidence dementia. <h3>Design, Setting, and Participants</h3> Population-based study UK, Whitehall II prospective cohort study, established 1985-1988, clinical examinations 1991-1993, 1997-1999, 2002-2004, 2007-2009,...
<h3>Importance</h3> It is well established that selected lifestyle factors are individually associated with lower risk of chronic diseases, but how combinations these disease-free life-years unknown. <h3>Objective</h3> To estimate the association between healthy and number life-years. <h3>Design, Setting, Participants</h3> A prospective multicohort study, including 12 European studies as part Individual-Participant-Data Meta-analysis in Working Populations Consortium, was performed....
<h3>Abstract</h3> <h3>Objective</h3> To examine the association between alcohol consumption and risk of dementia. <h3>Design</h3> Prospective cohort study. <h3>Setting</h3> Civil service departments in London (Whitehall II study). <h3>Participants</h3> 9087 participants aged 35-55 years at study inception (1985/88). <h3>Main outcome measures</h3> Incident dementia, identified through linkage to hospital, mental health services, mortality registers until 2017. Measures were mean from three...
BackgroundSocial inequalities in mortality persist high-income countries with universal health care, and the mechanisms by which these are generated remain unclear. We aimed to examine whether social were present before or after onset of adverse conditions (multimorbidity, frailty, disability).MethodsOur analysis was based on data from ongoing Whitehall II cohort study, enrolled British civil servants aged 35–55 years 1985–88. Participants assessed for three indicators socioeconomic status...
To examine associations of diastolic and systolic blood pressure (SBP) at age 50, 60, 70 years with incidence dementia, whether cardiovascular disease (CVD) over the follow-up mediates this association.
To examine the association between Life Simple 7 cardiovascular health score at age 50 and incidence of dementia.Prospective cohort study.Civil service departments in London (Whitehall II study; study inception 1985-88).7899 participants with data on 50.The included four behavioural (smoking, diet, physical activity, body mass index) three biological (fasting glucose, blood cholesterol, pressure) metrics, coded a point scale (0, 1, 2). The was sum seven metrics (score range 0-14) categorised...
There is need to identify targets for preventing or delaying dementia. Social contact a potential target clinical and public health studies, but previous observational studies had short follow-up, making findings susceptible reverse causation bias. We therefore examined the association of social with subsequent incident dementia cognition 28 years' follow-up.We conducted retrospective analysis Whitehall II longitudinal prospective cohort study employees London civil service departments, aged...
Approximately 25% of the general population carries at least one ε4 allele Apolipoprotein E (APOE ε4), strongest genetic risk factor for late onset Alzheimer's disease. Beyond its association with late-onset dementia, between APOE and change in cognition over adult life course remains uncertain. This study aims to examine whether (APOE) zygosity function is modified midlife old age.A cohort 5561 participants (mean age 55.5 (SD = 5.9) years, 27.1% women) genotyping repeated cognitive tests...
Abstract Objective To examine the association of midlife and late life multimorbidity, including severity with incident dementia. Design Prospective cohort study. Setting Civil service departments in London (Whitehall II study, study inception 1985-88). Participants 10 095 participants, aged 35 to 55 at baseline. Main outcome measure Incident dementia follow-up between 1985 2019. Cause specific Cox proportional hazards regression was used multimorbidity overall age 55, 60, 65, 70 subsequent...