Ashley van der Spek
A5045499040- Metabolomics and Mass Spectrometry Studies
- Genetic Associations and Epidemiology
- Telomeres, Telomerase, and Senescence
- Birth, Development, and Health
- Diet and metabolism studies
- Sleep and related disorders
- Tryptophan and brain disorders
- Epigenetics and DNA Methylation
- Liver Disease Diagnosis and Treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Single-cell and spatial transcriptomics
- Genetics, Aging, and Longevity in Model Organisms
- Cytomegalovirus and herpesvirus research
- Nutritional Studies and Diet
- Cognitive Abilities and Testing
- Nutrition, Genetics, and Disease
- Genomic variations and chromosomal abnormalities
- Cholesterol and Lipid Metabolism
- Lipid metabolism and biosynthesis
- Sleep and Wakefulness Research
- Digestive system and related health
- Acute Lymphoblastic Leukemia research
- Advanced Biosensing Techniques and Applications
Erasmus MC
2012-2023
Erasmus University Rotterdam
2011-2021
Rotterdam University of Applied Sciences
2019
Massachusetts General Hospital
2015
Center for Human Genetics
2015
University of Amsterdam
2014
Abstract Predicting longer-term mortality risk requires collection of clinical data, which is often cumbersome. Therefore, we use a well-standardized metabolomics platform to identify metabolic predictors long-term in the circulation 44,168 individuals (age at baseline 18–109), whom 5512 died during follow-up. We apply stepwise (forward-backward) procedure based on meta-analysis results and 14 circulating biomarkers independently associating with all-cause mortality. Overall, these...
Abstract Sleep is an essential human function but its regulation poorly understood. Using accelerometer data from 85,670 UK Biobank participants, we perform a genome-wide association study of 8 derived sleep traits representing quality, quantity and timing, validate our findings in 5,819 individuals. We identify 47 genetic associations at P < 5 × 10 −8 , which 20 reach stricter threshold −10 . These include 26 novel with measures quality nocturnal duration. The majority identified...
Leukocyte telomere length (LTL) is a heritable biomarker of genomic aging. In this study, we perform genome-wide meta-analysis LTL by pooling densely genotyped and imputed association results across large-scale European-descent studies including up to 78,592 individuals. We identify 49 regions at false dicovery rate (FDR) < 0.05 threshold prioritize genes 31, with five highlighting nucleotide metabolism as an important regulator LTL. report six significant loci in or near SENP7, MOB1B,...
Abstract Both short and long sleep are associated with an adverse lipid profile, likely through different biological pathways. To elucidate the biology of sleep-associated we conduct multi-ancestry genome-wide sleep-SNP interaction analyses on three traits (HDL-c, LDL-c triglycerides). In total study sample (discovery + replication) 126,926 individuals from 5 ancestry groups, when considering either or time interactions in joint analyses, identify 49 previously unreported loci, 10 additional...
Abstract Metabolome reflects the interplay of genome and exposome at molecular level thus can provide deep insights into pathogenesis a complex disease like major depression. To identify metabolites associated with depression we performed metabolome-wide association analysis in 13,596 participants from five European population-based cohorts characterized for depression, circulating using ultra high-performance liquid chromatography/tandem accurate mass spectrometry (UHPLC/MS/MS) based...
End-stage renal disease (ESRD) patients treated with replacement therapy (RRT) have premature immunologically aged T cells which may underlie uremia-associated immune dysfunction. The aim of this study was to investigate whether uremia able induce ageing the cell compartment. For purpose, we examined degree immunological by examining differentiation status, thymic output via receptor excision circle (TREC) content and proliferative history relative telomere length in ESRD not on RRT.Compared...
Educational attainment is a key behavioural measure in studies of cognitive and physical health, socioeconomic status. We measured DNA methylation at 410,746 CpGs (N = 4152) identified 58 associated with educational loci characterized by pleiotropic functions shared neuronal, immune developmental processes. Associations overlapped those for smoking behaviour, but remained after accounting many CpGs: Effect sizes were on average 28% smaller genome-wide significant 11 adjusting 62% never...
Summary Cytomegalovirus (CMV) infection has been implicated in accelerated T cell ageing. End-stage renal disease (ESRD) patients have a severely immunologically aged compartment but also high prevalence of CMV infection. We investigated whether contributes to ageing ESRD patients. determined the thymic output by receptor excision circle (TREC) content and percentage CD31+ naïve cells. The proliferative history determination relative telomere length (RTL) differentiation status was...
Abstract Coffee is one of the most consumed beverages world-wide and primary sources caffeine intake. Given its important health economic impact, underlying genetics consumption has been widely studied. Despite these efforts, much still to be uncovered. In particular, use non-additive genetic models may uncover new information about variants driving coffee consumption. We have conducted a genome-wide association study in two Italian populations using additive, recessive dominant for...
Background: Alterations in insulin-like growth factor I (IGF-I) signaling have been associated with dementia and Alzheimer's disease (AD). Studies on the association between IGF-I levels risk inconclusive. We reported earlier that higher of receptor stimulating activity are a prevalence incidence dementia. Objective: In present study, we test robustness by extending follow-up period to 16 years investigate possible effect modification apolipoprotein E (ApoE). Methods: At baseline,...
Abstract Background Chronic obstructive pulmonary disease (COPD) is a common lung disorder characterized by persistent and progressive airflow limitation as well systemic changes. Metabolic changes in blood may help detect COPD an earlier stage predict prognosis. Methods We conducted comprehensive study of circulating metabolites, measured proton Nuclear Magnetic Resonance Spectroscopy, relation with function. The discovery sample consisted 5557 individuals from two large population-based...
ABSTRACT Sleep is an essential human function but its regulation poorly understood. Identifying genetic variants associated with quality, quantity and timing of sleep will provide biological insights into the potential links disease. Using accelerometer data from 85,670 individuals in UK Biobank, we performed a genome-wide association study 8 accelerometer-derived traits, 5 which are not accessible through self-report alone. We identified 47 associations across traits ( P <5×10 -8 )...
Abstract Telomere shortening has been associated with multiple age-related diseases such as cardiovascular disease, diabetes, and dementia. However, the biological mechanisms responsible for these associations remain largely unknown. In order to gain insight into metabolic processes driving association of leukocyte telomere length (LTL) diseases, we investigated between LTL serum metabolite levels in 7,853 individuals from seven independent cohorts. was determined by quantitative polymerase...
Abstract Background Major depressive disorder (MDD) is a common mood disorder, with heritability of around 34%. Molecular genetic studies made significant progress and identified markers associated the risk MDD; however, slowed down by substantial heterogeneity as MDD assessed differently across international cohorts. Here, we used standardized online approach to measure in multiple cohorts Netherlands evaluated whether this can be epidemiological association depression. Methods Within...