A5048225510- Epigenetics and DNA Methylation
- Frailty in Older Adults
- Telomeres, Telomerase, and Senescence
- Birth, Development, and Health
- Genetics, Aging, and Longevity in Model Organisms
- Nutrition and Health in Aging
- Health Systems, Economic Evaluations, Quality of Life
- Intergenerational Family Dynamics and Caregiving
- COVID-19 and healthcare impacts
- Genetics and Neurodevelopmental Disorders
- Climate Change and Health Impacts
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Dietary Effects on Health
- Stress Responses and Cortisol
- Health and Wellbeing Research
- Long-Term Effects of COVID-19
- Cytomegalovirus and herpesvirus research
- Child and Adolescent Psychosocial and Emotional Development
- Nutritional Studies and Diet
- Global Health Care Issues
- Neuroendocrine regulation and behavior
- Prenatal Screening and Diagnostics
- Health disparities and outcomes
- Immune Cell Function and Interaction
- Cancer Genomics and Diagnostics
Karolinska Institutet
2021-2025
Tampere University
2016-2025
University of Helsinki
2008-2023
Institute for Molecular Medicine Finland
2008
Accelerated leukocyte telomere shortening has been previously associated to self-perceived stress and psychiatric disorders, including schizophrenia mood disorders. We set out investigate whether length is affected in patients with anxiety disorders which a known risk factor. also studied the effects of childhood recent psychological distress on length. utilized samples from nationally representative population-based Health 2000 Survey that was carried between 2000–2001 Finland assess major...
Human aging is associated with profound changes in one of the major epigenetic mechanisms, DNA methylation. Some these occur a clock-like fashion, i.e., correlating calendar age an individual, thus providing new biomarker. reports have identified factors acceleration age. However, it also important to analyze temporal age, duration observed acceleration, and effects possible therapeutic lifestyle modifications. To address this issue, we determined for cohort 183 healthy individuals using...
Changes in DNA methylation are among the mechanisms contributing to ageing process. We sought identify ageing-associated changes at single-CpG-site resolution blood leukocytes and ensure that observed were not due differences proportions of leukocytes. The association between gene expression levels was also investigated same individuals.We identified 8540 high-confidence CpG sites, 46% which hypermethylated nonagenarians. hypermethylation-associated genes belonged a common category: they...
Abstract Self-rated health (SRH) is one of the most frequently used indicators in and social research. Its robust association with mortality very different populations implies that it a comprehensive measure status may even reflect condition human organism beyond clinical diagnoses. Yet biological basis SRH poorly understood. We data from three independent European population samples (N approx. 15,000) to investigate associations 150 biomolecules blood or urine (biomarkers). Altogether 57...
Chronological aging-associated changes in the human DNA methylome have been studied by multiple epigenome-wide association studies (EWASs). Certain CpG sites identified as studies, and majority of various show common features regarding location direction methylation change. However, a whole, sets CpGs different even with similar tissues age ranges, only limited overlap. In this study, we further explore characterize that close relationship between their level chronological during adulthood...
Leukocyte telomere length (TL) is considered a biomarker for biological aging. Shortened TL has been observed in many complex diseases, including type 2 diabetes (T2DM). Lifestyle intervention studies, e.g. the Diabetes Prevention Study (DPS), have shown decrease incidence of T2DM by promoting healthy lifestyles individuals with impaired glucose tolerance (IGT). Our aim was to study DPS influence lifestyle on TL. measured quantitative PCR-based method at two time points (N = 334 and 343)...
Circulating cell-free DNA (cf-DNA) has emerged as a promising biomarker of ageing, tissue damage and cellular stress. However, less is known about health behaviours, ageing phenotypes metabolic processes that lead to elevated cf-DNA levels. We sought analyse the relationship circulating level age, sex, smoking, physical activity, vegetable consumption, (physical functioning, number diseases, frailty) an extensive panel biomarkers including blood urine metabolites inflammatory markers in...
Abstract Identifying metabolic biomarkers of frailty, an age‐related state physiological decline, is important for understanding its underpinnings and developing preventive strategies. Here, we systematically examined 168 nuclear magnetic resonance‐based metabolomic 32 clinical their associations with frailty. In up to 90,573 UK Biobank participants, identified 59 robustly independently associated the frailty index (FI). Of these, 34 were replicated in Swedish TwinGene study ( n = 11,025)...
Human anxiety disorders are complex diseases with largely unknown etiology. We have taken a cross-species approach to identify genes that regulate anxiety-like behavior inbred mouse strains differ in their innate levels as model. previously identified 17 expression correlate across the studied strains. In present study, we tested 13 known human homologues candidate for genetic association study.We describe an disorder study sample derived from Finnish population-based cohort and consisting...
Abstract Genetic mapping efforts have identified putative susceptibility genes for human anxiety disorders. The most intensively studied are involved in neurotransmitter metabolism and signaling or stress response. In addition, neuropeptides targets of anxiolytics been examined. It has become apparent that gene × environment interactions may explain individual variation resilience predisposition to mental We aimed replicate previous genetic findings 16 further test whether they modulate the...
Background Shorter leucocyte telomere length (LTL) is a promising marker of biological ageing. It predicted by cumulative adverse conditions throughout life course, but few studies have data from the prenatal period when most developmental processes and cell replication take place. We studied whether body size at birth underlying factors including severely preterm predict LTL in adult life. Methods used following three cohorts: (i) 1894 subjects (age: 56–69 years) Helsinki Birth Cohort Study...
Background & aimsOverweight and obesity have been consistently reported to carry an increased risk for poorer outcomes in coronavirus disease 2019 (COVID-19) adults. Existing reports mainly focus on in-hospital intensive care unit mortality patient cohorts usually not representative of the population with highest mortality, i.e. very old frail patients. Accordingly, little is known about patterns related body mass nutrition Our aim was assess relationship between index (BMI), nutritional...
Abstract Background Frailty assessment in the Swedish health system relies on Clinical Scale (CFS), but it requires training, in-person evaluation, and is often missing medical records. We aimed to develop an electronic frailty index (eFI) from routinely collected records (EHRs) assess its association with adverse outcomes hospitalized older adults. Methods EHRs were extracted for 18 225 patients unplanned admissions between 1 March 2020 17 June 2021 9 geriatric clinics Stockholm, Sweden. A...
Abstract Biological age (BA) captures detrimental age-related changes. The best-known and most-used BA indicators include DNA methylation–based epigenetic clocks telomere length (TL). most common biological sample material for epidemiological aging studies, whole blood, is composed of different cell types. We aimed to compare differences in BAs between blood types assessed the indicators’ type-specific associations with chronological (CA). An analysis indicators, including TL, methylation...
Previous research assessing whether biological ageing (BA) indicators can enhance the risk assessment of cardiovascular disease (CVD) outcomes beyond established CVD indicators, such as Framingham Risk Score (FRS) and Systematic Coronary Evaluation (SCORE2)/SCORE2-Older Persons (OP), is scarce. We explored BA namely Rockwood Frailty Index (FI) leukocyte telomere length (TL), improve predictive accuracy traditional in general population middle-aged older CVD-free individuals. Data included 14...
Telomeres constitute the protective ends of chromosomes. They become shorter after each cell division, and therefore, telomere length is considered as an indicator cellular aging. Interestingly, both inflammation oxidative stress, which play a role in etiology Parkinson's disease (PD), may accelerate shortening. Furthermore, it has been suggested that leukocyte shortening be accelerated PD. To replicate earlier findings, we analyzed peripheral blood leukocytes sample 131 PD patients (aged...