A5073924376- Frailty in Older Adults
- Health Systems, Economic Evaluations, Quality of Life
- Nutrition and Health in Aging
- Epigenetics and DNA Methylation
- Dementia and Cognitive Impairment Research
- Gestational Diabetes Research and Management
- COVID-19 and healthcare impacts
- Genetic factors in colorectal cancer
- Maternal Mental Health During Pregnancy and Postpartum
- Employment and Welfare Studies
- Birth, Development, and Health
- Health disparities and outcomes
- Nutritional Studies and Diet
- GDF15 and Related Biomarkers
- Diabetes and associated disorders
- Health, Environment, Cognitive Aging
- Long-Term Effects of COVID-19
- Psychological Well-being and Life Satisfaction
- Adipokines, Inflammation, and Metabolic Diseases
- Prenatal Substance Exposure Effects
- Migration and Labor Dynamics
- Pregnancy and preeclampsia studies
- Breastfeeding Practices and Influences
- Telomeres, Telomerase, and Senescence
- Osteoarthritis Treatment and Mechanisms
Karolinska Institutet
2020-2025
University of Hong Kong
2024-2025
Chinese University of Hong Kong
2019-2025
Curtin University
2018-2019
Despite a clear link between aging and cancer, there has been inconclusive evidence on how biological age (BA) may be associated with cancer incidence.
Background We examined the association of housing affordability with physical and mental health in Hong Kong, where there is a lack related research despite having worst problem world, considering potential mediating effect deprivation. Methods A stratified random sample 1978 Kong adults were surveyed. Housing was defined using residual-income (after costs) approach. Health-related quality life assessed by Short-Form Health Survey version 2 (SF-12v2), from which component summary (PCS) (MCS)...
Abstract Background/Objectives Frailty has been linked to increased risk of COVID‐19 mortality, but evidence is mainly limited hospitalized older individuals. This study aimed assess and compare predictive abilities different frailty comorbidity measures for mortality in a community sample inpatients. Design Population‐based cohort study. Setting Community. Participants We analyzed (i) the full 410,199 U.K. Biobank participants England, aged 49–86 years, (ii) subsample 2812 inpatients with...
There has been a rising trend of labor migration globally. Given their alien status within the legal framework host countries, migrant domestic workers (MDWs) are especially vulnerable to poor employment conditions that may affect health status, yet there is still lack quantitative evidence in this population hitherto. Using randomly sampled data from cross-sectional survey 2,017 live-in female MDWs Hong Kong, setting with high concentration MDWs, study examined association physical and...
Abstract Identifying metabolic biomarkers of frailty, an age‐related state physiological decline, is important for understanding its underpinnings and developing preventive strategies. Here, we systematically examined 168 nuclear magnetic resonance‐based metabolomic 32 clinical their associations with frailty. In up to 90,573 UK Biobank participants, identified 59 robustly independently associated the frailty index (FI). Of these, 34 were replicated in Swedish TwinGene study ( n = 11,025)...
Abstract Background Frailty assessment in the Swedish health system relies on Clinical Scale (CFS), but it requires training, in-person evaluation, and is often missing medical records. We aimed to develop an electronic frailty index (eFI) from routinely collected records (EHRs) assess its association with adverse outcomes hospitalized older adults. Methods EHRs were extracted for 18 225 patients unplanned admissions between 1 March 2020 17 June 2021 9 geriatric clinics Stockholm, Sweden. A...
Abstract While chronological age is the single biggest risk factor for cancer, it less clear whether frailty, an age-related state of physiological decline, may also predict cancer incidence. We assessed associations frailty index (FI) and phenotype (FP) scores with incidence any five common cancers (breast, prostate, lung, colorectal, melanoma) in 453,144 UK Biobank (UKB) 36,888 Screening Across Lifespan Twin study (SALT) participants, who aged 38–73 years had no diagnosis at baseline....
Although frailty is commonly considered as a syndrome of old individuals, recent studies show that it can affect younger adults, too. Whether and how differs in adults compared to however unknown. To this end, we analyzed the prevalence, characteristics, risk factors early-life (aged <65) late-life ≥65) frailty.
Abstract Biological age (BA) captures detrimental age-related changes. The best-known and most-used BA indicators include DNA methylation–based epigenetic clocks telomere length (TL). most common biological sample material for epidemiological aging studies, whole blood, is composed of different cell types. We aimed to compare differences in BAs between blood types assessed the indicators’ type-specific associations with chronological (CA). An analysis indicators, including TL, methylation...
Abstract Purpose Cancer-related genes and pathways have recently been implicated in a genome-wide meta-analysis of head size. In the current study, we aimed to evaluate association between adult circumference risk cancer. Methods This is cohort study using data from Hong Kong Osteoporosis Study, where 1,301 participants aged 27–96 years with measured 2015 2019, without history cancer, were followed up 15 January 2024. Incident cancers identified electronic medical records territory-wide...
Previous research assessing whether biological ageing (BA) indicators can enhance the risk assessment of cardiovascular disease (CVD) outcomes beyond established CVD indicators, such as Framingham Risk Score (FRS) and Systematic Coronary Evaluation (SCORE2)/SCORE2-Older Persons (OP), is scarce. We explored BA namely Rockwood Frailty Index (FI) leukocyte telomere length (TL), improve predictive accuracy traditional in general population middle-aged older CVD-free individuals. Data included 14...
Previous research has demonstrated the association between maternal dietary patterns and gestational diabetes (GDM), but evidence in Asian populations remains limited inconsistent. This study investigated during early pregnancy risk of GDM among pregnant women Western China. A prospective cohort was conducted 1337 Dietary intakes were assessed at 15–20 weeks gestation using a validated food frequency questionnaire. diagnosed by oral glucose tolerance tests 24–28 gestation. Exploratory factor...
Abstract Age is a dominant risk factor for some of the most common neurological diseases. Biological ageing encompasses interindividual variation in rate and can be calculated from clinical biomarkers or DNA methylation data amongst other approaches. Here, we tested hypothesis that biological age greater than one's chronological affects future diagnosis development abnormal signs on examination. We analysed Swedish Adoption/Twin Study Aging (SATSA): cohort with 3175 assessments 802...
Abstract Background DNA methylation-derived epigenetic clocks and frailty are well-established biological age measures capturing different aging processes. However, whether they dynamically linked to each other across chronological remains poorly understood. Methods This analysis included 1 309 repeated measurements in 524 individuals aged 50–90 years from the Swedish Adoption/Twin Study of Aging. Frailty was measured using a validated 42-item index (FI). Five were calculated, including 4...
Abstract Background Identifying effective risk assessment strategies and prediction models for frail populations is crucial precise mortality identification improved patient management. This study aimed to evaluate whether incorporating survey data combined with biomarkers, physical measurements, or both could enhance in individuals than survey-only models. Methods 15,754 participants aged 40-72 from the UK Biobank were included. We used Cox assess all-cause Light Gradient Boosting Machines...
Abstract Background Few studies have examined the age‐standardized incidence of gestational diabetes mellitus (GDM) for comparison between populations. Information on delivery outcomes is also lacking Chinese women with GDM. Therefore, present study aimed to determine GDM and assess its association maternal neonatal outcomes. Methods A total 1901 pregnant were recruited in Chengdu, Sichuan Province. was diagnosed 24 28 weeks’ gestation using oral glucose tolerance tests. Age‐standardized...
Background Many common neurological disorders are associated with advancing chronological age, but their association biological age (BA) remains poorly understood. Methods We studied 325 870 participants in the UK Biobank without a diagnosed condition at baseline and generated three previously-described measures of BA based on 18 routinely measured clinical biomarkers (PhenoAge, Klemera-Doubal method (KDMAge), homeostatic dysregulation age). Using survival models, we assessed effect advanced...
Frailty is a complex, dynamic geriatric condition, but limited evidence has shown how genes and environment may contribute to its longitudinal changes. We sought investigate sources of individual differences in the trajectories frailty, considering potential selection bias when including sample oldest-old twins.
Introduction: Frailty, a measure of biological aging, has been linked to worse COVID-19 outcomes. However, as the mortality differs across waves, it is less clear whether medical record-based electronic frailty index (eFI) that we have previously developed for older adults could be used risk stratification in hospitalized patients. Objectives: The aim study was examine association with mortality, readmission, and length stay patients compare predictive accuracy eFI other comorbidity...
Smokers are at increased risk of type 2 diabetes (T2D), but the underlying mechanisms unclear. We investigated if smoking-T2D association is mediated by alterations in metabolome and assessed potential interaction with genetic susceptibility to or insulin resistance.
There has been limited evidence on the long-term impacts of coffee intake health. We aimed to investigate association between and incidence diseases mortality risk over 20 years among community-dwelling Chinese adults.