A5073475622- Pharmaceutical Practices and Patient Outcomes
- Frailty in Older Adults
- Balance, Gait, and Falls Prevention
- Health Systems, Economic Evaluations, Quality of Life
- Intensive Care Unit Cognitive Disorders
- Nutrition and Health in Aging
- Schizophrenia research and treatment
- Blood Pressure and Hypertension Studies
- Pancreatic function and diabetes
- Chronic Disease Management Strategies
- Anesthesia and Sedative Agents
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer, Lipids, and Metabolism
- Dementia and Cognitive Impairment Research
- Infant Nutrition and Health
- Pediatric Hepatobiliary Diseases and Treatments
- Cholesterol and Lipid Metabolism
- Cardiovascular Function and Risk Factors
- Pharmacovigilance and Adverse Drug Reactions
- Alcoholism and Thiamine Deficiency
- Health Promotion and Cardiovascular Prevention
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Electrolyte and hormonal disorders
- Medication Adherence and Compliance
- Pharmacological Effects and Toxicity Studies
Rotterdam University of Applied Sciences
2023
Erasmus MC
2012-2022
Istituto Nazionale di Riposo e Cura per Anziani
2022
Istituti di Ricovero e Cura a Carattere Scientifico
2022
Erasmus University Rotterdam
1984-2020
Maasstad Ziekenhuis
2019-2020
Amsterdam UMC Location University of Amsterdam
2017
Apotheek Haagse Ziekenhuizen
2017
Harbour BioMed (Netherlands)
2013
Havenziekenhuis Rotterdam
2012
Aim Falls in the elderly are common and often serious. We studied association between multiple drug use (polypharmacy) falls elderly. Methods This was a population‐based cross‐sectional study, part of Rotterdam Study. The participants were 6928 individuals aged ≥ 55 years. prevalence previous year assessed. Medication determined with an interviewer‐administered questionnaire verification use. Polypharmacy defined as four or more drugs per day. Results strongly increased age. women than men....
Abstract Recent studies suggest that mild hyponatremia is associated with fractures, but prospective are lacking. We studied whether falls, and/or bone mineral density (BMD). A total of 5208 elderly subjects serum sodium assessed at baseline were included from the population-based Rotterdam Study. The following data analyzed: BMD, vertebral fractures (mean follow-up 6.4 years), nonvertebral (7.4 recent comorbidity, medication, and mortality. Hyponatremia was detected in 399 (7.7%, 133.4 ±...
The prevalence of cardiovascular diseases is rising. Therefore, adequate risk prediction and identification its determinants increasingly important. Rotterdam Study a prospective population-based cohort study ongoing since 1990 in the city Rotterdam, Netherlands. One main targets to identify prognosis diseases. Case finding epidemiological studies strongly depending on various sources follow-up clear outcome definitions. used for collection data are diverse definitions outcomes have changed...
Abstract Background Healthcare professionals are often reluctant to deprescribe fall-risk-increasing drugs (FRIDs). Lack of knowledge and skills form a significant barrier furthermore, there is no consensus on which medications considered as FRIDs despite several systematic reviews. To support clinicians in the management facilitate deprescribing process, STOPPFall (Screening Tool Older Persons Prescriptions older adults with high fall risk) tool were developed by European expert group....
Background.Despite frailty being an important geriatric syndrome, its prevalence and associated mortality risk in older patients with chronic obstructive pulmonary disease (COPD) are unknown.Methods.We examined the relationship between COPD confirmed by spirometry, severity, defined Fried criteria within 2,142 participants (aged 74.7 ± 5.6 years) of Rotterdam Study, a prospective population-based cohort study.Results.The was significantly higher (p < .001) (10.2%, 95% CI: 7.6%-13.5%)compared...
Background: Fractures related to osteoporosis and falling constitute a major health problem in the elderly population. Exposure antidepressants is associated with an increased risk of falls fractures, but most previous studies incriminate tricyclic (TCAs) rather than selective serotonin reuptake inhibitors (SSRIs). Objective: To examine association between antidepressants, including TCAs, SSRIs, other nonvertebral fractures elderly. Design: Prospective population-based cohort study. Setting:...
<h3>Importance</h3> Decision-making on management of proximal femoral fractures in frail patients with limited life expectancy is challenging, but surgical overtreatment needs to be prevented. Current literature provides insight into the true outcomes nonoperative and operative this patient population. <h3>Objective</h3> To investigate vs institutionalized older expectancy. <h3>Design, Setting, Participants</h3> This multicenter cohort study was conducted between September 1, 2018, April 25,...
The contribution of specific psychotropic drugs to fall risk in patients with dementia has not been quantified precisely until now. authors evaluated the dose-response relationship between and falls nursing home residents dementia. Daily drug use daily were recorded 248 from January 1, 2006, 2008. For each day study period, data on abstracted prescription database, retrieved a standardized incident report system, resulting set 85 074 person-days. found significant relationships for...
Recently it was found that lactoferrin, an iron-binding glycoprotein with a molecular weight of 76,500, inhibits the remnant receptor-mediated uptake apolipoprotein E (apoE)-bearing lipoproteins by liver. In present study we characterized hepatic recognition lactoferrin. Intravenously injected 125I-lactoferrin cleared rapidly from circulation liver (92.8 +/- 9.5% dose at 5 min after injection). Parenchymal cells contained 97.1 1.5% radioactivity. Internalization, monitored measuring release...
The uptake in vivo of chylomicrons and beta-migrating very-low-density lipoprotein (beta-VLDL) by rat liver, which is primarily carried out parenchymal cells, inhibited, 5 min after injection, to respectively 35 8% the control values preinjection lactoferrin. decrease lipoproteins liver caused lactoferrin a specific inhibition cells. Competition studies vitro demonstrate that chylomicron remnants beta-VLDL compete for same recognition site on Data obtained together with competition performed...
The Beers criteria for prescribing in elderly are well known and used many drug utilization studies. We investigated the clinical value of benzodiazepine use, notably association between inappropriate use risk fracture.
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Patients treated with selective serotonin re‐uptake inhibitors (SSRIs) have been shown to an increased risk of falling. In nursing homes, many patients dementia are given SSRIs as a treatment for depression. this group, however, the possible injurious falls by dosage is not known. STUDY ADDS Even at low doses, associated fall in home residents dementia. The increases higher three‐fold 1.00 Defined Daily Dose. combination SSRI hypnotic or sedative...
Falls are a major public health concern in the older population, and certain medication classes significant risk factor for falls. However, knowledge is lacking among both physicians people, including caregivers, concerning role of as factor. In present statement, European Geriatric Medicine Society (EuGMS) Task Finish group on fall-risk-increasing drugs (FRIDs), collaboration with EuGMS Special Interest Pharmacology Union Medical Specialists (UEMS) Section, outlines its position regarding...
Abstract Background Sarcopenia may be more present in older adults with diabetes (DM). Accordingly, we evaluated the prevalence of sarcopenia and its associated risk factors among community-dwelling DM. Methods A cross-sectional analysis people living community was carried out. Participants (aged 75 years more) came from an European multicenter prospective cohort (SCOPE study). Global geriatric assessment including short physical performance battery, handgrip strength test bioelectrical...
Abstract Purpose To estimate the association between use of typical and atypical antipsychotics all‐cause mortality in a population demented outpatients. Methods The study cohort comprised all patients older than 65 years registered Integrated Primary Care Information (IPCI) database, during 1996–2004. First, rates were calculated antipsychotics. Second, we assessed through nested case‐control patients. Each case was matched to eligible controls at date death by age duration dementia. Odds...
Low density lipoprotein (LDL) is a spherical particle with diameter of 22 nm. It consists an apolipoprotein and lipid moiety, in which variety lipophilic drugs prodrugs can be incorporated. In the present study, lactose was coupled to LDL by reductive amination (398 +/- 40 residues/LDL particle). After injection into rats, radioactively labeled lactosylated cleared rapidly from plasma (half-life, less than 2 min). Ten minutes after injection, liver contained about 90% dose, whereas only...
The diagnosis of delirium is not supported by specific biomarkers. In a previous study, high neopterin levels were found in patients with postoperative delirium. the present we investigated neopterin, interleukin-6 (IL-6) and insulin-like growth factor-1 (IGF-1) acutely ill admitted elderly without delirium.Plasma/serum IL-6 IGF-1 determined aged ≥65 years to wards Internal Medicine Geriatrics. Differences biomarker between analysis variance models adjusted for age, gender, comorbidities...
Abstract Background Chronic kidney disease (CKD) is known to be associated with several co-occurring conditions. We aimed at exploring multimorbidity patterns CKD, as well the impact of physical performance and CKD severity on them in a population older outpatients. Methods Our series consisted 2252 patients enrolled Screening among Older People across Europe multicenter observational study. Hypertension, stroke, transient ischemic attack, cancer, hip fracture, osteoporosis, Parkinson’s...