Tobias Feldreich
A5061096177- Cardiovascular Health and Disease Prevention
- Chronic Kidney Disease and Diabetes
- Bone and Dental Protein Studies
- Dialysis and Renal Disease Management
- Frailty in Older Adults
- Birth, Development, and Health
- Vitamin D Research Studies
- Nutrition and Health in Aging
- Cardiovascular Disease and Adiposity
- Adipokines, Inflammation, and Metabolic Diseases
- Advanced Proteomics Techniques and Applications
- Chronic Disease Management Strategies
- Blood Pressure and Hypertension Studies
- Acute Kidney Injury Research
- Erythropoietin and Anemia Treatment
- Protease and Inhibitor Mechanisms
- Regulation of Appetite and Obesity
- Neuropeptides and Animal Physiology
- GDF15 and Related Biomarkers
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Fatty Acid Research and Health
- Oral microbiology and periodontitis research
- Lipoproteins and Cardiovascular Health
- Digestive system and related health
- Blood Coagulation and Thrombosis Mechanisms
Karolinska Institutet
2018-2024
Dalarna University
2016-2024
Center for Clinical Research Dalarna
2022-2023
Uppsala University
2018-2022
Istituto Nazionale di Riposo e Cura per Anziani
2022
Istituti di Ricovero e Cura a Carattere Scientifico
2022
Linköping University
2020
Umeå University
2020
Science for Life Laboratory
2018
Falun Hospital
2017
Abstract Type 2 diabetes mellitus is characterized by a low-grade inflammation; however, mechanisms leading to this inflammation in specific tissues are not well understood. The eye can be affected diabetes; thus, we hypothesized that inflammatory changes the may parallel develops with diabetes. Here, developed non-invasive means monitor status of dendritic cell (DC) subsets corneal epithelium as potential biomarker for onset type In an age-matched cohort 81 individuals normal and impaired...
The effect of marine omega-3 PUFAs on risk stroke remains unclear.
Background and objectives Using a discovery/replication approach, we investigated associations between multiplex panel of 80 circulating proteins associated with cardiovascular pathology or inflammation, eGFR decline per year CKD incidence. Design, setting, participants, & measurements We used two cohorts, the Prospective Investigation Vasculature in Uppsala Seniors Study (PIVUS; n =687, mean age 70 years, 51% women) Longitudinal Adult Men (ULSAM; =360 men, 78 years), 5-year follow-up...
Proteomic profiling of end-stage renal disease (ESRD) patients could lead to improved risk prediction and novel insights into cardiovascular mechanisms. Plasma levels 92 disease-associated proteins were assessed by proximity extension assay (Proseek Multiplex CVD-1, Olink Bioscience, Uppsala, Sweden) in a discovery cohort dialysis patients, the Mapping Inflammatory Markers Chronic Kidney [MIMICK; n = 183, 55% women, mean age 63 years, 46 deaths during follow-up (mean 43 months)]. Significant...
Multiplex proteomics could improve understanding and risk prediction of major adverse cardiovascular events (MACE) in type 2 diabetes. This study assessed 80 inflammatory proteins for biomarker discovery MACE We combined data from six prospective epidemiological studies 30–77-year-old individuals with diabetes whom circulating were measured by proximity extension assay. Multivariable-adjusted Cox regression was used a discovery/replication design to identify biomarkers incident MACE....
Abstract Background Sarcopenia may be more present in older adults with diabetes (DM). Accordingly, we evaluated the prevalence of sarcopenia and its associated risk factors among community-dwelling DM. Methods A cross-sectional analysis people living community was carried out. Participants (aged 75 years more) came from an European multicenter prospective cohort (SCOPE study). Global geriatric assessment including short physical performance battery, handgrip strength test bioelectrical...
Abstract Venous thromboembolism (VTE) is the third most common type of cardiovascular disease. An association between high level physical activity (PA) and onset VTE has been found in some, but not all previous studies. We aim to study PA-level a cohort men with updated data on PA levels at four occasions. used from Uppsala Longitudinal Study Adult Men (ULSAM) initiated 1970, age 50 years ( n = 2,294 baseline) examined leisure time by questionnaire traditional risk factors. Examinations were...
Abstract Background Chronic kidney disease (CKD) is known to be associated with several co-occurring conditions. We aimed at exploring multimorbidity patterns CKD, as well the impact of physical performance and CKD severity on them in a population older outpatients. Methods Our series consisted 2252 patients enrolled Screening among Older People across Europe multicenter observational study. Hypertension, stroke, transient ischemic attack, cancer, hip fracture, osteoporosis, Parkinson’s...
<b><i>Background and Objectives:</i></b> The matricellular protein osteopontin is involved in the pathogenesis of both kidney cardiovascular disease. However, whether circulating urinary levels are associated with risk these diseases less studied. <b><i>Design, Setting, Participants, Measurements:</i></b> A community-based cohort elderly men (Uppsala Longitudinal Study Adult Men [ULSAM]; <i>n</i> = 741; mean age: 77 years) was used...
Previous proteomics efforts in patients with chronic kidney disease (CKD) have predominantly evaluated urinary protein levels. Therefore, our aim was to investigate the association between plasma levels of 80 cardiovascular disease-related proteins and risk major adverse events (MACE) CKD.Individuals CKD stages 3-5 (eGFR below 60 ml min-1 [1.73 m]-2) from three community-based cohorts (PIVUS, ULSAM, SAVA), one diabetes cohort (CARDIPP) peripheral artery (PADVA) information on biomarkers,...
Different mechanisms connect the nutritional status with occurrence and course of chronic kidney disease (CKD). The end-stage renal is complicated by catabolic inflammatory reactions cachexia which leads to malnutrition (undernutrition). On other hand, obesity an important risk factor for development acceleration CKD.In SCOPE study, community-dwelling persons aged 75 years over, from 6 European countries Israel were examined at baseline phase. We assessed relationship between anthropometric...
C-reactive protein (CRP)/Albumin ratio (CAR) seems to mirror disease severity and prognosis in several acute disorders particularly elderly patients, which we aimed study. As method use a prospective study design; the Prospective Investigation of Vasculature Uppsala Seniors (PIVUS; n = 912, women 50%; mean age 70 years, baseline 2001 2004, median follow-up 15.0 end 2019) Longitudinal Study Adult Men (ULSAM, 924 71 1991-1995, 15.6 2016). Serum samples were used for analyses CRP Albumin. Cox...
Abstract Background age-adapted definition of chronic kidney disease (CKD) does not take individual risk factors into account. We aimed at investigating whether functional impairments influence CKD stage which mortality increases among older people. Methods our series consisted 2,372 outpatients aged 75 years or more enrolled in a multicentre international prospective cohort study. The study outcome was 24-month mortality. Kidney function assessed by estimated glomerular filtration rate...
Abstract Introduction: Proteomics may help discover novel biomarkers and underlying mechanisms for cardiovascular disease. This could be useful childhood cancer survivors as they show an increased risk of The aim this study was to investigate circulating proteins in young adult their relationship previously reported subclinical Methods: Ninety-two were measured 57 52 controls. For that significantly different between controls, we performed correlations protein levels measures peripheral...
We aimed to discover novel associations between leptin and circulating proteins which could link the development of cardiovascular disease in patients with type 2 diabetes (T2DM). In a discovery phase, we investigated 88 plasma proteins, assessed proximity extension assay, cohort middle-aged T2DM. Associations passing significance threshold False rate 5% (corresponding p < 0.0017) were replicated T2DM an independent cohort. also if mediated longitudinal association incidence major events...
Abstract Background and Aims A strong cardiorespiratory fitness is suggested to have beneficial effects on cardiovascular risk; the exact mechanisms underlying cardioprotective of remain uncertain. Our aim was investigate associations between multiple plasma proteins, in order obtain insights about physiological pathways associated with exercise health. Methods In Prospective investigation Obesity, Energy Metabolism (POEM) study ( n =444 adults aged 50 years, 50% women), measured by a...
Abstract Background The beneficial effects of physical activity on cardiovascular risk are well documented. Yet, the underlying mechanisms by which prevents disease remain unclear (1). Advancements omics technology enables us to explore novel biomarkers this complex molecular relationship and potentially unravel involved in progression events. Purpose To investigate associations between long term plasma proteins. As a second step identified proteins future myocardial infarction mortality....
Plasma osteopontin (pOPN) is a promising aging-related biomarker among individuals with and without kidney disease. The interaction between sex, pOPN levels, global cardiorenal outcomes older was not previously evaluated.
Several novel urinary kidney damage biomarkers predict the progression of disease. However, relations these to atherosclerosis, a major consequence disease, are less studied. Urinary levels several biomarkers, including injury molecule-1 (KIM-1), osteopontin, epidermal growth factor, and Dickkopf-3, were assessed in participants enrolled Swedish CArdioPulmonary BioImage Study. The study included 9,628 individuals with mean age 57.5 years, which 52.4% women. presence coronary artery stenosis...
Background: Higher circulating levels of tumor necrosis factor (TNF) alpha receptors 1 (TNFR1) and 2 (TNFR2) are associated with increased long-term mortality impaired kidney function. Aim: To study associations between TNFR1 TNFR2 all-cause as well estimated glomerular filtration rate (eGFR) decline. Population methods: Patients chronic disease (CKD) stages 3–5 in the Salford Kidney Study were included. Associations one standard deviation increase plasma by Cox regression models hazard...