A5043064517- Fatty Acid Research and Health
- Nutritional Studies and Diet
- Vitamin D Research Studies
- Diet and metabolism studies
- Obesity, Physical Activity, Diet
- Eicosanoids and Hypertension Pharmacology
- Diet, Metabolism, and Disease
- Folate and B Vitamins Research
- Vitamin C and Antioxidants Research
- Antioxidant Activity and Oxidative Stress
- Cardiovascular Disease and Adiposity
- Metabolomics and Mass Spectrometry Studies
- Bone health and osteoporosis research
- Liver Disease Diagnosis and Treatment
- Birth, Development, and Health
- Mercury impact and mitigation studies
- Lipid metabolism and biosynthesis
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Alcohol Consumption and Health Effects
- Sodium Intake and Health
- Blood Pressure and Hypertension Studies
- Iron Metabolism and Disorders
- Muscle metabolism and nutrition
- Consumer Attitudes and Food Labeling
- Adipokines, Inflammation, and Metabolic Diseases
University of Eastern Finland
2016-2025
Turku University Hospital
2001-2023
Cambridge University Press
2023
New York University Press
2023
Kuopio University Hospital
2002-2022
Deakin University
2022
Black Dog Institute
2022
Murdoch Children's Research Institute
2022
Finland University
2019-2020
Institute of Public Health
2019
Background: Virgin olive oils are richer in phenolic content than refined oil. Small, randomized, crossover, controlled trials on the antioxidant effect of compounds from real-life daily doses oil humans have yielded conflicting results. Little information is available plasma lipid levels. No international study with a large sample size has been done. Objective: To evaluate whether further benefits levels and oxidative damage compared monounsaturated acid content. Design: Randomized, trial....
<h3>Importance</h3> The role of ω-3 polyunsaturated fatty acids for primary prevention coronary heart disease (CHD) remains controversial. Most prior longitudinal studies evaluated self-reported consumption rather than biomarkers. <h3>Objective</h3> To evaluate biomarkers seafood-derived eicosapentaenoic acid (EPA; 20:5ω-3), docosapentaenoic (DPA; 22:5ω-3), and docosahexaenoic (DHA; 22:6ω-3) plant-derived α-linolenic (ALA; 18:3ω-3) incident CHD. <h3>Data Sources</h3> A global consortium 19...
Abstract The health effects of omega-3 fatty acids have been controversial. Here we report the results a de novo pooled analysis conducted with data from 17 prospective cohort studies examining associations between blood acid levels and risk for all-cause mortality. Over median 16 years follow-up, 15,720 deaths occurred among 42,466 individuals. We found that, after multivariable adjustment relevant factors, death all causes was significantly lower (by 15–18%, at least p < 0.003) in...
Abstract Background LC-MS technology makes it possible to measure the relative abundance of numerous molecular features a sample in single analysis. However, especially non-targeted metabolite profiling approaches generate vast arrays data that are prone aberrations such as missing values. No matter reason for values data, coherent and complete matrix is always pre-requisite accurate reliable statistical Therefore, there need proper imputation strategies account missingness reduce bias...
Abstract The 6th International Conference, “Controversies in Vitamin D,” was convened to discuss controversial topics, such as vitamin D metabolism, assessment, actions, and supplementation. Novel insights into mechanisms of action suggest links with conditions that do not depend only on reduced solar exposure or diet intake can be detected distinctive noncanonical metabolites. Optimal 25-hydroxyvitamin (25(OH)D) levels remain debated. Varying recommendations from different societies arise...
Mercury has been suggested to have negative effects on cardiovascular health. We investigated the of high mercury content in hair risk acute coronary events and all-cause mortality men from eastern Finland.The population-based prospective Kuopio Ischaemic Heart Disease Risk Factor Study (KIHD) cohort 1871 Finnish aged 42 60 years free previous heart disease (CHD) or stroke at baseline was used. During an average follow-up time 13.9 years, 282 132 (CVD), 91 CHD, 525 deaths occurred. Men...
Background —Although several prospective studies have shown that low folate intake and circulating are associated with increased risk of coronary heart disease (CHD), the findings inconsistent. Methods Results —We studied associations dietary folate, vitamin B 6 , 12 acute events in a cohort study 1980 Finnish men 42 to 60 years old examined 1984 1989 Kuopio Ischemic Heart Disease Risk Factor Study. Nutrient intakes were assessed by 4-day food record. During an average follow-up time 10...
Atrial fibrillation (AF) is a common cardiac arrhythmia. Regular fish consumption has been shown to reduce the risk of AF in some but not all studies. Long-chain n-3 polyunsaturated fatty acids (PUFAs) from have suggested account for these beneficial effects. We tested this hypothesis by studying association between serum long-chain PUFAs eicosapentaenoic acid, docosapentaenoic and docosahexaenoic acid men.A total 2174 men prospective population-based Kuopio Ischemic Heart Disease Risk...
OBJECTIVE The relationship between fish or omega-3 polyunsaturated fatty acids (PUFAs) and type 2 diabetes is inconclusive. Even contaminants in fish, such as mercury, may modify the effects. We investigated associations serum PUFAs eicosapentaenoic acid (EPA), docosapentaenoic (DPA), docosahexaenoic (DHA), α-linolenic (ALA), hair risk of incident middle-aged older Finnish men. RESEARCH DESIGN AND METHODS A total 2,212 men from prospective, population-based Kuopio Ischemic Heart Disease Risk...
Vitamin D insufficiency is associated with risks of cardiovascular diseases (CVD) and cancer in observational studies, but evidence for benefits vitamin supplementation limited. To investigate the effects D3 on CVD incidences. The study was a 5-year, randomized, placebo-controlled trial among 2495 male participants ≥60 years post-menopausal female ≥65 from general Finnish population who were free prior or cancer. had 3 arms: placebo, 1600 IU/day, 3200 IU/day D3. Follow-up by annual...