A5057135738- Blood Pressure and Hypertension Studies
- Atrial Fibrillation Management and Outcomes
- Chronic Kidney Disease and Diabetes
- Chronic Disease Management Strategies
- Health Systems, Economic Evaluations, Quality of Life
- Nutritional Studies and Diet
- Obesity, Physical Activity, Diet
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Dialysis and Renal Disease Management
- Health Promotion and Cardiovascular Prevention
- Nutrition and Health in Aging
- Cardiac Health and Mental Health
- Acute Kidney Injury Research
- Cardiovascular Health and Disease Prevention
- Birth, Development, and Health
- Heart Failure Treatment and Management
- Cardiac Arrhythmias and Treatments
- Emergency and Acute Care Studies
- Diabetes Management and Education
- Migration, Health and Trauma
- Liver Disease Diagnosis and Treatment
- Health disparities and outcomes
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes Management and Research
- Acute Ischemic Stroke Management
Karolinska Institutet
2016-2025
Stockholm Health Care Services
2020-2025
Dalarna University
2013-2024
Healthcare in Sweden
2020-2024
Primary Health Care
2024
Uppsala University
2012-2020
Science for Life Laboratory
2013-2018
Uppsala University Hospital
2013-2018
Stockholm County Council
2016
Centre for Family Medicine
2013-2014
<h2>Summary</h2><h3>Background</h3> One of the global targets for non-communicable diseases is to halt, by 2025, rise in age-standardised adult prevalence diabetes at its 2010 levels. We aimed estimate worldwide trends diabetes, how likely it countries achieve target, and changes prevalence, together with population growth ageing, are affecting number adults diabetes. <h3>Methods</h3> pooled data from population-based studies that had collected on through measurement biomarkers. used a...
There is limited knowledge on the prevalence of disease in total populations. Such studies have historically been difficult to conduct but development health data registers has facilitated large-scale recorded diagnoses entire regions. The aim this study was analyze diagnosis six common diseases Swedish capital region.The population included all living persons who resided Stockholm County, Sweden, December 31st 2011 (N=2 093 717). Information consultations between 2007 and obtained from...
The most commonly reported diagnoses in primary care are useful to identify and meet health needs society. We estimated the rates of common total also by gender.This was a cross-sectional study including all 2.0 million inhabitants living Stockholm County, Sweden, on 1 January 2009. Data appointments made 2011 during 2009-11 were extracted from County Council data warehouse VAL (Vårdanalysdatabasen; regional warehouse). Primary analysed underlying population age. Appropriate specialist open...
Summary Background and objectives Circulating fibroblast growth factor-23 is associated with adverse cardiovascular outcomes in CKD non-CKD individuals, but the underlying mechanism remains unclear. This study tested whether this association independent of mineral metabolism indices subclinical pathology. Design, setting, participants, & measurements The prospective between major events (a composite hospital-treated myocardial infarction, stroke, or all-cause mortality) was investigated...
Abstract Background Obesity and lack of physical activity are frequently reported in persons with intellectual disability (ID) or autism spectrum disorder (ASD). We hypothesised a higher prevalence diabetes hypertension this population. Method used administrative data for all primary specialist outpatient inpatient healthcare consultations people at least one recorded diagnosis mellitus, obesity from 1998 to 2015. Data were drawn the central database Stockholm County, Sweden. It was not...
Abstract Background Chronic stress and depression are potential risk factors for mild cognitive impairment dementia, including Alzheimer disease. The aim was to investigate whether any such is additive. Methods Cohort study 1 362 548 people (665 997 women, 696 551 men) with records in the Region Stockholm administrative healthcare database (VAL). Exposure a recorded ICD-10 diagnosis of chronic stress, depression, or both, 2012 2013. Outcome disease, other from 2014 through 2022. Odds ratios...
Soluble tumor necrosis factor receptors 1 and 2 (sTNFR1 sTNFR2) contribute to experimental diabetic kidney disease, a condition with substantially increased cardiovascular risk when present in patients. Therefore, we aimed explore the levels of sTNFRs, their association prevalent incident mortality independently baseline function microalbuminuria cohort patients type diabetes. In pre-defined secondary analyses also investigated whether sTNFRs predict adverse outcome absence disease.The...
Aim We aimed to investigate whether different measures of obesity could similarly predict atrial fibrillation, and the fibrillation risk associated with is dependent on presence metabolic syndrome. Material Methods performed our study in a population-based longitudinal cardiovascular study, comprising 1 924 men 2 097 women, aged 60 years, from Stockholm. Body mass index, waist circumference, sagittal abdominal diameter components syndrome (systolic- diastolic blood pressure, fasting glucose,...
Objective: The objective of this study was to investigate the prevalence concomitant hypertension and psychiatric disorders in general population, using administrative healthcare data Stockholm County. Design method: included all living persons who resided County 1 January 2011 (N = 2 058 408). Individuals with a diagnosis were identified from consultations primary care, specialized outpatient inpatient care 2009–2013. As outcome, obtained on because certain diagnoses between 2013, including...
Aims: To investigate factors related to unsafe medication management among 75-year-olds during preventive home visits, and describe the interventions district nurses used. Methods: An explorative study. During a 9- 12-month period, 36 DNs used Safe Medication Assessment (SMA) tool visits who at least one drug ( n=113). Results: One or more were identified in 84% of 75-year-olds. More than 40% five drugs, 34.5% reported symptoms potentially indicative adverse effects their drugs. Nearly 30%...
Background and objectives Using a discovery/replication approach, we investigated associations between multiplex panel of 80 circulating proteins associated with cardiovascular pathology or inflammation, eGFR decline per year CKD incidence. Design, setting, participants, & measurements We used two cohorts, the Prospective Investigation Vasculature in Uppsala Seniors Study (PIVUS; n =687, mean age 70 years, 51% women) Longitudinal Adult Men (ULSAM; =360 men, 78 years), 5-year follow-up...
Proteomic profiling of end-stage renal disease (ESRD) patients could lead to improved risk prediction and novel insights into cardiovascular mechanisms. Plasma levels 92 disease-associated proteins were assessed by proximity extension assay (Proseek Multiplex CVD-1, Olink Bioscience, Uppsala, Sweden) in a discovery cohort dialysis patients, the Mapping Inflammatory Markers Chronic Kidney [MIMICK; n = 183, 55% women, mean age 63 years, 46 deaths during follow-up (mean 43 months)]. Significant...
Background: Diabetic kidney disease (DKD) is a leading risk factor for end-stage renal and one of the most important factors cardiovascular in patients with diabetes. It possible that novel markers portraying pathophysiological underpinning processes may be useful. Aim: To investigate associations between 80 circulating proteins, measured by proximity extension assay, prevalent DKD major adverse events (MACE) type 2 Methods: We randomly divided individuals diabetes from three cohorts into...
Multiplex proteomics could improve understanding and risk prediction of major adverse cardiovascular events (MACE) in type 2 diabetes. This study assessed 80 inflammatory proteins for biomarker discovery MACE We combined data from six prospective epidemiological studies 30–77-year-old individuals with diabetes whom circulating were measured by proximity extension assay. Multivariable-adjusted Cox regression was used a discovery/replication design to identify biomarkers incident MACE....
Financial stress may have adverse health effects. The main aim of this study was to investigate whether having a cash margin and living alone or cohabiting is associated with incident cardiovascular disease (CVD) all-cause mortality. Representative population-based prospective cohort 60-year-old women (n = 2065) men 1939) in Stockholm County, Sweden. National registers were used identify cases CVD 375) mortality 385). presence determined the questionnaire following question: Would you, if an...
The primary biomarkers used to define CKD are serum creatinine and albuminuria. These have directed focus on the filtration barrier functions of kidney glomerulus even though albuminuria results from tubule dysfunction as well. Given that proximal tubules make up ∼90% cortical mass, we evaluated whether a sensitive specific marker injury, urinary injury molecule-1 (KIM-1), is elevated in individuals with or risk factors for CKD. We measured KIM-1 participants five cohort studies USA Sweden....
Background: Diagnostic errors are a major patient safety concern in primary healthcare and emergency care. These settings involve high degree of uncertainty regarding patients' diagnoses appear to be those most prone diagnostic errors. comprise missed, delayed, or incorrect preventing the from receiving correct timely treatment. Data which affected these scarce.Objectives: To understand distribution among reported health care as step towards creating countermeasures for safer care.Methods: A...