A5062830660- Parathyroid Disorders and Treatments
- Cardiac Imaging and Diagnostics
- Advanced X-ray and CT Imaging
- Dialysis and Renal Disease Management
- Vitamin D Research Studies
- Vitamin K Research Studies
- Radiation Dose and Imaging
- Bone health and osteoporosis research
- Coronary Interventions and Diagnostics
- Advanced MRI Techniques and Applications
- Folate and B Vitamins Research
- Renal function and acid-base balance
- GDF15 and Related Biomarkers
- Cardiac Valve Diseases and Treatments
- Nutrition and Health in Aging
- Aortic Thrombus and Embolism
- Cardiovascular Function and Risk Factors
- Pharmacological Effects and Toxicity Studies
- Thyroid Disorders and Treatments
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Renal and Vascular Pathologies
- Lipoproteins and Cardiovascular Health
- Radiology practices and education
- Organ Transplantation Techniques and Outcomes
- Chronic Kidney Disease and Diabetes
Karolinska University Hospital
2009-2023
Karolinska Institutet
2013-2023
Medical University of Vienna
2009
Matrix Gla protein (MGP) is a potent inhibitor of vascular calcification (VC) and requires carboxylation by vitamin K to exert inhibition. Chronic kidney disease (CKD) patients undergo early aging often involving extensive VC. The present cross-sectional study investigated the association between circulating dp-ucMGP levels, MGP expression in tissue polymorphisms. In 141 CKD stage 5 patients, CAC score was significantly increased highest tertile (p = 0.002), high medial VC associated with...
In end-stage renal disease (ESRD), coronary artery calcification (CAC) and inflammation contribute to cardiovascular (CVD). Statins do not improve survival in patients with ESRD, their effect on vascular is unclear. We explored associations between CAC, inflammatory biomarkers, statins mortality ESRD.In 240 ESRD (63% males; median age 56 years) from cohorts including 86 recipients of living donor kidney transplant (LD-Rtx), 96 incident dialysis 58 prevalent peritoneal patients, CAC score...
Aging | doi:10.18632/aging.101173. Peter Stenvinkel, Karin Luttropp, Dagmara McGuinness, Anna Witasp, Abdul Rashid Qureshi, Annika Wernerson, Louise Nordfors, Martin Schalling, Jonaz Ripsweden, Lars Wennberg, Magnus Söderberg, Bárány, Hannes Olauson, Paul G Shiels
Proteomic profiling of end-stage renal disease (ESRD) patients could lead to improved risk prediction and novel insights into cardiovascular mechanisms. Plasma levels 92 disease-associated proteins were assessed by proximity extension assay (Proseek Multiplex CVD-1, Olink Bioscience, Uppsala, Sweden) in a discovery cohort dialysis patients, the Mapping Inflammatory Markers Chronic Kidney [MIMICK; n = 183, 55% women, mean age 63 years, 46 deaths during follow-up (mean 43 months)]. Significant...
Low triiodothyronine levels, as part of the nonthyroidal illness syndrome, are common in dialysis patients and have repeatedly been shown to be associated with increased (cardiovascular) mortality rates. We hypothesized that vascular calcification may mediate this relationship.A total 84 from Stockholm region receiving maintenance peritoneal were included study. Serum concentrations free (fT3), thyroxine thyroid-stimulating hormone measured. Coronary artery calcium (CAC) scores assessed by...
Vascular calcification is a common, serious and elusive complication of end-stage renal disease (ESRD). As pro-calcifying risk factor, non-thyroidal illness may promote vascular through systemic lowering inhibitors such as matrix-gla protein (MGP) Klotho.In 97 ESRD patients eligible for living donor kidney transplantation, blood levels thyroid hormones (fT3, fT4 TSH), total uncarboxylated MGP (t-ucMGP), desphospho-uncarboxylated (dp-ucMGP), descarboxyprothrombin (PIVKA-II), soluble Klotho...
Patients with chronic kidney disease (CKD) suffer from vitamin K deficiency and are at high risk of vascular calcification (VC) premature death. We investigated the association functional all-cause mortality whether this is modified by presence VC in CKD stage 5 (CKD G5). Plasma dephosphorylated-uncarboxylated matrix Gla-protein (dp-ucMGP), a circulating marker deficiency, other laboratory clinical data were determined 493 G5 patients. was assessed subgroups Agatston scoring coronary artery...
Anthropometric indices of central obesity, waist circumference (WC), conicity index (CI), and a-body shape (ABSI), are prognostic indicators cardiovascular (CV) risk. The association CI ABSI with other CV risk indices, markers nutritional status inflammation, clinical outcomes in chronic kidney disease (CKD) stage 5 (CKD5) patients was investigated.In a cross-sectional study longitudinal follow up 203 clinically stable CKD5 (median age 56 years; 68% males, 17% diabetics, 22% disease, 39%...
Sex differences are underappreciated in the current understanding of cardiovascular disease (CVD) association with chronic kidney (CKD). A hallmark CKD is vascular aging that characterised, amongst others, by; systemic inflammation, microbiota disbalance, oxidative stress, and calcification-features linked to atherosclerosis/arteriosclerosis development. Thus, it necessary introduce novel biomarkers related athero-/arteriosclerotic damage for better assessment ageing patients CKD. However,...
Chronic kidney disease (CKD) is linked to an increased cardiovascular (CVD) burden. Albeit underappreciated, sex differences are evident in CKD with females being more prone development, but males progressing rapidly failure (KF). Cardiovascular remodelling a hallmark of arterial and valvular calcification contributing CKD. However, little known regarding calcific KF patients. Thus, we hypothesise that present coronary artery (CAC) aortic valve (AVC) patients KF.
The risk of radiation-induced cancer has become a major concern with the increasing use computed tomography (CT).To compare image quality and radiation doses when decreasing X-ray tube peak kilovoltage (kVp) from 120 to 100 kVp in patients undergoing coronary CT angiography (CCTA).Patients referred for evaluation suspected artery disease (CAD) underwent 64-channel detector CCTA using voltage either (n = 46) or 82). individual volume dose index (CTDI(vol)) length product (DLP) were recorded...
The coronary artery calcium (CAC) score from cardiac computed tomography (CT) is a composite of CAC volume and density. In the general population, positively density inversely associated with cardiovascular disease (CVD) events, implying that decreased reflects atherosclerotic plaque instability. We analysed associations indices mortality risk in patients end-stage renal [chronic kidney Stage 5 (CKD5)].In 296 CKD5 undergoing CT (median age 55 years, 67% male, 19% diabetes, 133 dialysed),...
Abstract Background Progression of vascular calcification causes cardiovascular disease, which is the most common cause death in chronic kidney failure and after transplantation (KT). The prognostic impact extent medial at KT unknown. Methods In this prospective cohort study, we investigated compared to a mix intimal represented by coronary artery (CAC score) aortic valve 342 patients starting on replacement therapy. primary outcomes were events (CVE) death. median follow‐up time was 6.4...
During computed tomography coronary angiography (CTCA) unexpected changes in heart rate while scanning may affect image quality.To evaluate whether an iso-osmolar contrast medium (IOCM, iodixanol) and a low-osmolar (LOCM, iomeprol) experienced heat sensation differently.One hundred patients scheduled for CTCA were randomized to receive either iodixanol 320 mgI/ml or iomeprol 400 mgI/ml. Depending on their rate, the assigned one of five protocols, each optimized different ranges. time between...
Objectives Patients presenting with acute myocardial infarction and angiographically normal coronary arteries (MINCA) represent a diagnostic therapeutic challenge. Cardiac computed tomography (CT) allows detection of artery disease (CAD) even in the absence significant stenosis. We aimed to investigate whether patients suffering from MINCA had greater plaque burden, as determined by cardiac CT, than matched group healthy volunteers. Methods Consecutive patients, aged 45 70, were enrolled...
Vascular calcification (VC) is an independent predictor of cardiovascular disease (CVD) present in 30-70% patients with chronic kidney (CKD). Copeptin a sensitive surrogate marker arginine vasopressin (AVP), which involved many pathophysiologic processes CKD. The aim the study was to explore association copeptin VC CKD stage 5.Copeptin investigated conjunction living donor transplantation 149 clinically stable 5 (CKD5), including 53 non-dialyzed (CKD5-ND) and 96 dialysis treated by...
Risk of cardiac events and cardiovascular disease (CVD) in end-stage renal (ESRD) patients are predicted by coronary artery calcification (CAC) independently. It is not clear to what extent low bone mineral density (BMD) associated with higher risk CAC if sex interacts. We investigated the sex-specific associations score total body BMD (tBMD) as well different skeletal sub-regions. In 174 ESRD patients, median age 57 (10th–90th percentiles 29–75) years, 63% males, (measured dual-energy X-ray...
Cardiac computed tomography (CT) has gained increasing acceptance for diagnosing obstructive coronary artery disease (CAD). Several guidelines have been published on required education proficiency in the interpretation of these examinations.To describe learning-curve effect 100 consecutive cardiac CT examinations aimed at CAD. The diagnostic accuracy radiologists and radiographers was also compared.Two two radiographers, all with no prior experience evaluation CT, independently underwent a...
Background: Recently, 64-detector-row computed tomography coronary angiography (CTA) has been introduced for the noninvasive diagnosis of artery disease. Purpose: To evaluate diagnostic capacity and limitations a newly established CTA service. Material Methods: In 101 outpatients with suspected disease, (VCT Lightspeed 64; GE Healthcare, Milwaukee, Wisc., USA) was performed before invasive (ICA). The presence >50% diameter stenosis on rated by two radiologists recently trained in CTA,...
Background: Aortic valve calcium (AVC) and coronary artery (CAC) are common complications in end-stage renal disease (ESRD). We investigated the prognostic significance of overlapping presence AVC CAC, whether was associated with all-cause mortality independent CAC ESRD. Methods: 259 ESRD patients (median age 55 years, 67% males) undergoing cardiac computed tomography were included. Framingham risk score (FRS), cardiovascular (CVD), statin use, nutritional status other relevant laboratory...