A5034450801- Blood Pressure and Hypertension Studies
- Birth, Development, and Health
- Advanced X-ray and CT Imaging
- Radiation Dose and Imaging
- Heart Rate Variability and Autonomic Control
- Social and Educational Sciences
- Pregnancy and preeclampsia studies
- MRI in cancer diagnosis
- Mechanical Circulatory Support Devices
- Central Venous Catheters and Hemodialysis
- Cardiac Imaging and Diagnostics
- Diabetes Treatment and Management
- Hemodynamic Monitoring and Therapy
- Advancements in Photolithography Techniques
- Renin-Angiotensin System Studies
- Cardiac Valve Diseases and Treatments
- Cardiac Arrest and Resuscitation
- Hormonal Regulation and Hypertension
- Vitamin K Research Studies
- Advanced MRI Techniques and Applications
- Pharmacology and Obesity Treatment
- Cardiac Structural Anomalies and Repair
- Infective Endocarditis Diagnosis and Management
- Vascular anomalies and interventions
- Peroxisome Proliferator-Activated Receptors
Karolinska Institutet
2016-2025
Karolinska University Hospital
2015-2025
Linköping University
2024
Mycronic (Sweden)
2015-2024
Roche (Switzerland)
2013-2019
Denver VA Medical Center
2017
Montreal Heart Institute
2017
Université de Montréal
2017
University of Gothenburg
2015
AstraZeneca (Sweden)
2003-2006
No therapy directed against diabetes has been shown to unequivocally reduce the excess risk of cardiovascular complications. Aleglitazar is a dual agonist peroxisome proliferator-activated receptors with insulin-sensitizing and glucose-lowering actions favorable effects on lipid profiles.To determine whether addition aleglitazar standard medical reduces morbidity mortality among patients type 2 mellitus recent acute coronary syndrome (ACS).AleCardio was phase 3, multicenter, randomized,...
The aim of the Antihypertensive Treatment and Lipid Profile in a North Sweden Efficacy Evaluation study was to compare long-term effect commonly used inexpensive medication with low-dose diuretic (hydrochlorothiazide), alone or combination beta-adrenoceptor (atenolol), that more modern but also expensive antihypertensive treatment an angiotensin-II-receptor blocker (candesartan), calcium antagonist (felodipine), do so newly diagnosed patients primary hypertension. objectives included...
Objective The aim of the Antihypertensive Treatment and Lipid Profile in a North Sweden Efficacy Evaluation study was to compare long-term effect commonly used inexpensive medication with low-dose diuretic (hydrochlorothiazide), alone or combination β-adrenoceptor (atenolol), that more modern but also expensive antihypertensive treatment an angiotensin-II-receptor blocker (candesartan), calcium antagonist (felodipine), do so newly diagnosed patients primary hypertension. objectives included...
The hereditary multiple endocrine neoplasia syndromes types 2A and B (MEN B) were recently linked to germline mutations in the RET proto-oncogene, altering one of five cysteine residues exon 10 or 11 2A), substituting a methionine for threonine at codon 918 16 2B). latter mutation also occurs somatically some sporadic medullary thyroid carcinomas (MTC), has previous study been correlated with less favorable clinical outcome. In present study, 46 MTCs selected investigation mutation. was...
Abstract Venovenous extracorporeal membrane oxygenation (ECMO) can be performed with two single lumen cannulas (SLCs) or one dual-lumen cannula (DLC) where low recirculation fraction ( $${R}_{f}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msub><mml:mi>R</mml:mi><mml:mi>f</mml:mi></mml:msub></mml:math> ) is a key performance criterion. DLCs are widely believed to have lower , though these not been directly compared. Similarly, correct positioning considered critical...
Purpose: To assess the accuracy of transaortic valve replacement (TAVR) planning CT examinations with a broad detector and single dose contrast media to diagnose CAD in large patient cohort. Materials Methods: In this retrospective study, consecutive patients who underwent dedicated TAVR examination 320-detector row between November 2017 March 2021 were screened for inclusion. Inclusion criteria complete correctly performed exam as well an invasive coronary angiography (ICA). The scan...
Abstract Background We evaluated the diagnostic capability of photon-counting detector computed tomography (PCD-CT) spectral variables in late arterial phase (LAP) and portal venous (PVP) to discriminate between local tumor recurrence (LTR) postoperative changes (POC) after pancreatic ductal adenocarcinoma (PDAC) resection. Methods Seventy-three consecutive PCD-CT scans 73 patients with soft-tissue lesions (PSLs) were included, 42 POC 31 LTR. Regions interest drawn each PSL, calculated:...
Summary TP53 is mutated in 10–20% of cases chronic lymphocytic leukaemia (CLL) and 3–8% acute myeloid (AML). Recently, two classes compounds that restore the function p53 tumours have been described. PRIMA‐1 (p53‐dependent reactivation induction massive apoptosis) restores wild‐type conformation mutant , whereas RITA (reactivation tumour cell increases intracellular levels p53. We evaluated effects alone combination with or conventional cytostatics on leukaemic cells isolated from AML CLL...
Background The prevalence of hypo‐attenuated leaflet thickening ( HALT ) and reduced motion RLM is unknown in surgically implanted bioprostheses because systematic investigation and/or limited to a few catheter‐based valves. aim this study was investigate the by cardiac computed tomography patients who underwent surgical aortic valve replacement received Perceval sutureless bioprosthesis. Methods Results This single‐center prospective observational that included 47 (83.5% total number...
1 In a double‐blind study, 36 patients with essential hypertension were randomly allocated to treatment either metoprolol, 100–300 mg/day, or pindolol, 5–15 mg/day for 6 months. Haemodynamic investigations made on three separate occasions. Blood flow in the calves and forearm was determined by venous occlusion plethysmography after weeks of placebo, again months active therapy. 2 Both drugs reduced blood pressure significantly, 17.1/11.8 mm Hg metoprolol 21.9/10.9 pindolol (P less than...
OBJECTIVE In observational cohorts, adiponectin is inversely associated and free fatty acids (FFAs) are directly with incident coronary heart disease (CHD). Adiponectin tends to be reduced FFAs elevated in type 2 diabetes. We investigated relationships of FFA major adverse cardiovascular events (MACEs) death patients acute syndrome (ACS) diabetes using data from the AleCardio (Effect Aleglitazar on Cardiovascular Outcomes After Acute Coronary Syndrome Patients With Type Diabetes Mellitus)...
Purpose: To evaluate and compare the diagnostic accuracy of duplex ultrasound (US) MR angiography (MRA) at 1.0 T in aortoiliac arterial disease using digital subtraction (DSA) as reference standard. In addition, a comparison 2D time-of flight (TOF) 3D contrast-enhanced MRA (CE MRA) techniques was performed. Material Methods: Prospectively, 39 patients with symptoms lower-extremity occlusive were examined US, TOF MRA, CE DSA. Significant lesions (stenosis ≥50%) occlusions evaluated blindly...
ABSTRACT. A review on the effects of ageing cardiovascular function, with special reference to high blood pressure (BP), is given in this seminar. In most western populations diastolic and especially systolic BP increases age both sexes has been observed cross‐sectional longitudinal studies. Over 60 decreases. Of different risk factors for diseases, only shown consistently be an independent indicator subjects 70 years or older. Hypotensive drugs used treatment middle‐aged hypertensive...
Abstract Venovenous extracorporeal membrane oxygenation is a treatment for acute respiratory distress syndrome. Femoro-atrial cannulation means blood drained from the inferior vena cava and returned to superior cava; opposite termed atrio-femoral. Clinical data comparing these two methods scarce conflicting. Using computational fluid dynamics, we aim compare atrio-femoral femoro-atrial assess impact on recirculation fraction, under ideal conditions several clinical scenarios....
During computed tomography coronary angiography (CTCA) unexpected changes in heart rate while scanning may affect image quality.To evaluate whether an iso-osmolar contrast medium (IOCM, iodixanol) and a low-osmolar (LOCM, iomeprol) experienced heat sensation differently.One hundred patients scheduled for CTCA were randomized to receive either iodixanol 320 mgI/ml or iomeprol 400 mgI/ml. Depending on their rate, the assigned one of five protocols, each optimized different ranges. time between...
Background When the same dose of iodine is given to all patients when performing abdominal computed tomography (CT) there may be a wide inter-individual variation in contrast medium (CM) enhancement liver. Purpose To evaluate if any measures body height (BH), mass index (BMI), lean (LBM), ideal weight (IBW), and surface area (BSA) correlated better than (BW) with hepatic enhancement, compare using iodixanol iomeprol. Material Methods One hundred referred for standard three-phase CT...
The right atrium (RA) combines the superior vena cava (SVC) and inferior (IVC) flows. Treatments like extracorporeal membrane oxygenation (ECMO) hemodialysis by catheter alter IVC/SVC Here we assess how altered flow contributions impact RA flow. Four healthy volunteers were imaged with computerized tomography (CT), reconstructed combined into a patient-averaged model. Large eddy simulations (LESs) performed for range of (30%-70% each, increments 5%) common metrics recorded. Model sensitivity...
Abstract. This paper presents an optimal predictor of level crossings, catastrophes, for autoregressive moving‐average processes, and investigates the performance predictor. The catastrophe is that gives a minimal number false alarms fixed detection probability. As tool evaluating, comparing constructing predictors method using operating characteristics, i.e. probability correct alarm detecting predictor, used. An explicit condition based on linear prediction future process values given...
Abstract The right atrium (RA) combines flows from the inferior (IVC) and superior vena cava (SVC). Here RA mixing is simulated using computational fluid dynamics, comparing four modeling approaches. A patient-averaged model (11 M cells) was created volunteers. We compared: (1) unsteady k–ω Reynolds-averaged Navier–Stokes (URANS) (2) implicit large eddy simulation with second-order upwind convection scheme (iLES-SOU) (3) iLES bounded-central difference (iLES-BCD) (4) LES wall-adapting local...
ABSTRACT. Ketanserin, a new 5‐hydroxy‐tryptamine antagonist, was given at three different dosage levels (double‐blind, randomized) in dose finding study for 2 months to 31 patients with mild moderately severe essential hypertension. Treatment ketanserin then continued until 9 had been completed. A significant antihypertensive effect demonstrated daily dosages of 20 mg t.i.d. or 40 The similar that previous multiple drug treatment conventional drugs. However, 60 not acceptable, least as...
Purpose To develop and evaluate a triple arterial phase CT liver protocol with similar radiation dose to that of standard single in study subjects suspected having hepatocellular carcinoma (HCC). Materials Methods The consisted retrospective part A for development (n = 15) prospective B diagnostic accuracy 38). All 53 participants underwent perfusion 50 mL contrast material between August 2013 September 2014. Group an additional multiphasic examination 120 (range, 70–143 mL). Image sets from...