A5061226100- Cardiovascular Health and Disease Prevention
- Blood Pressure and Hypertension Studies
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Cardiovascular Disease and Adiposity
- Diabetes Treatment and Management
- Diabetes Management and Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Diabetes Management and Education
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Nutritional Studies and Diet
- Heart Rate Variability and Autonomic Control
- Diet and metabolism studies
- Thermoregulation and physiological responses
- Adipokines, Inflammation, and Metabolic Diseases
- Chronic Disease Management Strategies
- Diabetes and associated disorders
- Metabolism, Diabetes, and Cancer
- Cardiovascular Health and Risk Factors
- Obesity and Health Practices
- Infrared Thermography in Medicine
- Respiratory Support and Mechanisms
- Cerebrovascular and Carotid Artery Diseases
- Frailty in Older Adults
- Cardiac Valve Diseases and Treatments
Linköping University
2016-2025
Lund University
1999-2025
Karolinska Institutet
2020-2024
Linköping University Hospital
2011-2023
Macquarie University
2023
Praktikertjänst
2022
Boston University
2021
Leeds Teaching Hospitals NHS Trust
2020
University of Leeds
2020
Karolinska University Hospital
2020
Abstract Cardiopulmonary diseases are major causes of death worldwide, but currently recommended strategies for diagnosis and prevention may be outdated because recent changes in risk factor patterns. The Swedish CArdioPulmonarybioImage Study (SCAPIS) combines the use new imaging technologies, advances large‐scale ‘omics’ epidemiological analyses to extensively characterize a cohort 30 000 men women aged between 50 64 years. information obtained will used improve prediction cardiopulmonary...
Early detection of coronary atherosclerosis using computed tomography angiography (CCTA), in addition to artery calcification (CAC) scoring, may help inform prevention strategies. We used CCTA determine the prevalence, severity, and characteristics its association with CAC scores a general population. recruited 30 154 randomly invited individuals age 50 64 years SCAPIS (the Swedish Cardiopulmonary Bioimage Study). The study includes without known heart disease (ie, no previous myocardial...
The study aimed to compare the effects of a 2 year intervention with low-fat diet (LFD) or low-carbohydrate (LCD), based on four group meetings achieve compliance. This was prospective randomised parallel trial involving 61 adults type diabetes consecutively recruited in primary care and by drawing ballots. Patients that did not speak Swedish could be recruited. outcomes this non-blinded were weight HbA1c. LFD for 55–60 energy per cent (E%) those LCD 20 E% from carbohydrate. mean BMI HbA1c...
Abstract Background Dipeptidyl peptidase‐4 inhibitors improve glycaemic control in patients with type 2 diabetes mellitus when used as monotherapy or combination other anti‐diabetic drugs (metformin, sulphonylurea, thiazolidinedione). This 18‐week, phase 3b, multicentre, double‐blind, noninferiority trial compared the efficacy and safety of two dipeptidyl inhibitors, saxagliptin sitagliptin, whose glycaemia was inadequately controlled metformin. Methods Adult ( N = 801) glycated haemoglobin...
Abstract Aim To investigate the changes in prevalence and incidence of pharmacologically non‐pharmacologically treated diabetes Sweden during 2005 to 2013. Methods We obtained data on gender, date birth from national registers for all Swedish residents. Results During study period a total 240 871 new cases was found. The age‐standardized follow‐up 4.34 3.16 per 1000 individuals men women, respectively. A decreasing time trend 0.6% year (0.994, 95% CI 0.989–0.999) women 0.7% (0.993,...
The present study aims to describe accelerometer-assessed physical activity (PA) patterns and fulfillment of PA recommendations in a large sample middle-aged men women, differences between subgroups socio-demographic, socio-economic, lifestyle-related variables. A total 27 890 (92.5% participants, 52% aged 50-64 years) women with at least four days valid hip-worn accelerometer data (Actigraph GT3X+, wGT3X+ wGT3X-BT) from the Swedish CArdioPulmonary bioImage Study, SCAPIS, were included. In...
Abstract Background and aim Dysglycaemia is a known risk factor for cardiovascular disease microcirculatory dysfunction associated with an increased risk. The of this study was to investigate the prevalence impaired microcirculation, coronary atherosclerosis, arterial stiffness in individuals normo- dysglycaemia. Methods included 3,300 participants measurements information on glycaemic status, aged 50–65 years, from Linköping site Swedish CArdio-Pulmonary bioImage Study (SCAPIS)....
Aortic valve calcification (AVC) is an underlying pathophysiological mechanism in aortic stenosis, which shares many risk factors with diabetes. However, the association between dysglycemia and early stages of AVC remains unclear. The aim was to examine associations signs among middle-aged individuals from general population. This a cross-sectional study Swedish CArdioPulmonary bioImage Study (SCAPIS) randomly enrolling 30,154 men women six sites Sweden 2013 2018. Glycemic status based on...
Aim: To explore the prevalence of atrial fibrillation in patients with hypertension and type 2 diabetes to identify possible mechanisms for development fibrillation. Methods: A community‐based, cross‐sectional observational study was conducted primary health care Skara, Sweden, 1739 subjects (798 men, 941 women) were surveyed. Patients categorized as those only (n = 597); both 171), 147). In reference population, 824 normotensive without identified used controls. Participants examined...
Obesity is associated with type 2 diabetes mellitus, left ventricular diastolic dysfunction and heart failure but it unclear to which extent related systolic dysfunction. The aim of the study was explore effects overweight obesity on function in patients mellitus a control group non-diabetic persons.We prospectively investigated 384 184 controls who participated CARDIPP CAREFUL studies. participants were grouped according body mass index (normal weight < 25 kg/m2, 25-29 ≥ 30 kg/m2)....
Soluble tumor necrosis factor receptors 1 and 2 (sTNFR1 sTNFR2) contribute to experimental diabetic kidney disease, a condition with substantially increased cardiovascular risk when present in patients. Therefore, we aimed explore the levels of sTNFRs, their association prevalent incident mortality independently baseline function microalbuminuria cohort patients type diabetes. In pre-defined secondary analyses also investigated whether sTNFRs predict adverse outcome absence disease.The...
Background: Diabetic kidney disease (DKD) is a leading risk factor for end-stage renal and one of the most important factors cardiovascular in patients with diabetes. It possible that novel markers portraying pathophysiological underpinning processes may be useful. Aim: To investigate associations between 80 circulating proteins, measured by proximity extension assay, prevalent DKD major adverse events (MACE) type 2 Methods: We randomly divided individuals diabetes from three cohorts into...
Objectives To examine the associations between physical fitness in male adolescents and coronary carotid atherosclerosis middle age. Methods This population-based cohort study linked data from Swedish Military Conscription Register during adolescence to CArdioPulmonary bioImage Study Cardiorespiratory was assessed using a maximal cycle-ergometer test, knee extension muscular strength evaluated through an isometric dynamometer. Coronary via Computed Tomography Angiography (CCTA) stenosis...
Abstract Aims The aim was to investigate the relationship between microvascular function, cardiovascular risk profile, and subclinical atherosclerotic burden. Methods results study enrolled 3809 individuals, 50–65 years old, participating in population-based observational cross-sectional Swedish CArdioPulmonary bioImage Study. Microvascular function assessed forearm skin using an arterial occlusion release protocol determining peak blood oxygen saturation (OxyP). Cardiovascular calculated...
Aims To assess the efficacy and safety of adjunctive saxagliptin vs glimepiride in elderly patients with type 2 diabetes ( T2D ) inadequate glycaemic control. Methods In this multinational, randomized, double‐blind, phase IIIb / IV study GENERATION ; NCT01006603 ), aged ≥65 years were randomized (1 : 1) to receive 5 mg/day or ≤6 mg/day, added metformin, during a 52‐week treatment period. The primary endpoint was achievement glycated haemoglobin HbA1c <7.0% at week 52 without...
The aim of this study was to explore the association between pedometer-determined physical activity versus measures obesity, inflammatory markers and arterial stiffness in people with Type 2 diabetes.We analysed data from 224 men 103 women diabetes, aged 54-66 years. Physical measured waist-mounted pedometers during three consecutive days number steps/day were calculated classified four groups: < 5000 steps/day, 5000-7499 7500-9999 ≥ 10000 steps/day. Blood samples for lipids, HbA(1c),...
Multiplex proteomics could improve understanding and risk prediction of major adverse cardiovascular events (MACE) in type 2 diabetes. This study assessed 80 inflammatory proteins for biomarker discovery MACE We combined data from six prospective epidemiological studies 30–77-year-old individuals with diabetes whom circulating were measured by proximity extension assay. Multivariable-adjusted Cox regression was used a discovery/replication design to identify biomarkers incident MACE....
AimsThe aim of the study was to determine whether left ventricular systolic function, in terms global longitudinal strain (GLS), and diastolic expressed as ratio between early transmitral flow mitral annular motion velocities (E/e′), can predict cardiovascular events patients with diabetes mellitus type 2.
Obesity, type 2 diabetes and atrial fibrillation (AF) are closely associated, but the underlying mechanisms not fully understood. We aimed to explore associations between body mass index (BMI) or weight change with risk of AF in patients diabetes. A total 7,169 participations newly diagnosed were stratified according baseline BMI, after a second BMI measurement within 18 months, further grouped relative as "weight gain" (>1 unit), "stable weight" (+/− 1 unit) loss" (<1 unit). The mean...