A5015326593- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Health and Disease Prevention
- Cardiac Imaging and Diagnostics
- Cardiovascular Disease and Adiposity
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Blood Pressure and Hypertension Studies
- Physical Activity and Health
- Gut microbiota and health
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Function and Risk Factors
- Diet and metabolism studies
- Nutritional Studies and Diet
- Cardiovascular and exercise physiology
- Heavy Metal Exposure and Toxicity
- Nitric Oxide and Endothelin Effects
- Obesity, Physical Activity, Diet
- Liver Disease Diagnosis and Treatment
- Heart Rate Variability and Autonomic Control
- Plant and animal studies
- Insect and Pesticide Research
- Atherosclerosis and Cardiovascular Diseases
- Renin-Angiotensin System Studies
- Lipoproteins and Cardiovascular Health
- Birth, Development, and Health
- Adipose Tissue and Metabolism
University of Gothenburg
2016-2025
Sahlgrenska University Hospital
2016-2025
Region Västra Götaland
2019-2025
Karolinska Institutet
1991-2024
National Academy of Medicine
2017-2024
Massachusetts General Hospital
2023
Stockholm University
2018
Centre de Recherche en Économie et Statistique
2018
Sorbonne Paris Cité
2018
Inserm
2018
Several platelet-derived growth factor (PDGF) and vascular endothelial (VEGF) family members display C-terminal protein motifs that confer retention of the secreted factors within pericellular space. To address role PDGF-B in vivo, we deleted motif by gene targeting mice. This resulted defective investment pericytes microvessel wall delayed formation renal glomerulus mesangium. Long-term effects lack included severe retinal deterioration, glomerulosclerosis, proteinuria. We conclude...
A database provides information on the relative abundances and locations of human proteins that are predicted to be secreted.
Abstract Cardiopulmonary diseases are major causes of death worldwide, but currently recommended strategies for diagnosis and prevention may be outdated because recent changes in risk factor patterns. The Swedish CArdioPulmonarybioImage Study (SCAPIS) combines the use new imaging technologies, advances large‐scale ‘omics’ epidemiological analyses to extensively characterize a cohort 30 000 men women aged between 50 64 years. information obtained will used improve prediction cardiopulmonary...
Early detection of coronary atherosclerosis using computed tomography angiography (CCTA), in addition to artery calcification (CAC) scoring, may help inform prevention strategies. We used CCTA determine the prevalence, severity, and characteristics its association with CAC scores a general population. recruited 30 154 randomly invited individuals age 50 64 years SCAPIS (the Swedish Cardiopulmonary Bioimage Study). The study includes without known heart disease (ie, no previous myocardial...
Temporal dynamics of the gut microbiota potentially limit identification microbial features associated with health status. Here, we used whole-genome metagenomic and 16S rRNA gene sequencing to characterize intra- inter-individual variations composition functional potential a disease-free Swedish population (n = 75) over one year. We found that 23% total compositional variance was explained by intra-individual variation. The degree variability negatively abundance Faecalibacterium...
The microbes and microbial pathways that influence host inflammatory disease progression remain largely undefined. Here, we show variation in atherosclerosis burden is partially driven by gut microbiota associated with circulating levels of uric acid (UA) mice humans. We identify bacterial taxa spanning multiple phyla, including Bacillota, Fusobacteriota, Pseudomonadota, use purines, UA as carbon energy sources anaerobically. a gene cluster encodes key steps anaerobic purine degradation...
BACKGROUND: Gut microbiota have been implicated in atherosclerotic disease, but their relation with subclinical coronary atherosclerosis is unclear. This study aimed to identify associations between the gut microbiome and computed tomography–based measures of explore relevant clinical correlates. METHODS: We conducted a cross-sectional 8973 participants (50 65 years age) without overt disease from population-based SCAPIS (Swedish Cardiopulmonary Bioimage Study). Coronary was measured using...
While macro- and microscopic kidney development appear to proceed normally in mice that lack Foxi1, electron microscopy reveals an altered ultrastructure of cells lining the distal nephron. Northern blot analyses, cRNA situ hybridizations, immunohistochemistry demonstrate a complete loss expression several anion transporters, proton pumps, exchange proteins expressed by intercalated collecting ducts, many which have been implicated hereditary forms renal tubular acidosis (dRTA). In...
Current Swedish guidelines recommend that carotid endarterectomy should be performed within 14 days of a qualifying neurological event, but it is not clear if very urgent surgery after an event associated with increased perioperative risk. The aim this study was to determine how the time between and affects procedural risk mortality stroke.We prospectively analyzed data on all patients who underwent endarterectomies for symptomatic stenosis May 12, 2008, 31, 2011, records in Vascular...
Abstract An important aspect of precision medicine is to probe the stability in molecular profiles among healthy individuals over time. Here, we sample a longitudinal wellness cohort with 100 and analyze blood including proteomics, transcriptomics, lipidomics, metabolomics, autoantibodies immune cell profiling, complemented gut microbiota composition routine clinical chemistry. Overall, our results show high variation between across different readouts, while intra-individual baseline low....
Abstract Aim To study the characteristics and outcome among cardiac arrest cases with COVID-19 differences between pre-pandemic pandemic period in out-of-hospital (OHCA) in-hospital (IHCA). Method results We included all patients reported to Swedish Registry for Cardiopulmonary Resuscitation from 1 January 20 July 2020. defined 16 March 2020 as start of pandemic. assessed overall 30-day mortality using Cox regression logistic regression, respectively. studied 1946 OHCA 1080 IHCA during...
Background Previous studies on the relation between lifestyle and metabolic syndrome lack one or several aspects of physical activity pattern in analyses cardiorespiratory fitness. Likewise, both uni- triaxial accelerometry have been used, though, predictive validity these two modes has not compared. Objectives The aims present study were firstly to investigate independent fitness (MetS) secondly examine accelerometry, respectively. Methods Data was extracted from SCAPIS pilot (n=930, mean...
Abstract The need for precision medicine approaches to monitor health and disease makes it important develop sensitive accurate assays proteome profiles in blood. Here, we describe an approach plasma profiling based on proximity extension assay combined with next generation sequencing. First, analyze the variability of between within healthy individuals a longitudinal wellness study, including influence genetic variations levels. Second, follow patients newly diagnosed type 2 diabetes before...
The present study aims to describe accelerometer-assessed physical activity (PA) patterns and fulfillment of PA recommendations in a large sample middle-aged men women, differences between subgroups socio-demographic, socio-economic, lifestyle-related variables. A total 27 890 (92.5% participants, 52% aged 50-64 years) women with at least four days valid hip-worn accelerometer data (Actigraph GT3X+, wGT3X+ wGT3X-BT) from the Swedish CArdioPulmonary bioImage Study, SCAPIS, were included. In...
BackgroundPrevious population-based studies investigating the relationship between physical activity and gut microbiota have relied on self-reported activity, prone to reporting bias. Here, we investigated associations of accelerometer-based sedentary (SED), moderate-intensity (MPA), vigorous-intensity (VPA) with using cross-sectional data from Swedish CArdioPulmonary bioImage Study.MethodsIn 8416 participants aged 50–65, time in SED, MPA, VPA were estimated hip-worn accelerometer. Gut was...
Abstract Alterations in gut microbiota composition are suggested to contribute cardiometabolic diseases, part by producing bioactive molecules. Some of the metabolites produced very low abundant bacterial taxa, which largely have been neglected due limits detection. However, concentration microbially from these taxa can still reach high levels and substantial impact on host physiology. To explore this concept, we focused generation secondary bile acids 7α-dehydroxylating bacteria...
We examined whether end-to-end deep-learning models could detect moderate (≥50%) or severe (≥70%) stenosis in the left anterior descending artery (LAD), right coronary (RCA) circumflex (LCX) iodine contrast-enhanced ECG-gated CT angiography (CCTA) scans. From a database of 6293 CCTA scans, we used pre-existing curved multiplanar reformations (CMR) images LAD, RCA and LCX arteries to create for detection stenoses. preprocessed by exploiting domain knowledge employed transfer learning approach...
IL-6 is produced and released in large amounts from skeletal muscle during prolonged exercise both mice humans, but there are few data indicating the biological significance of this. exerts metabolic effects such as stimulating energy expenditure reducing body fat mass. We have now investigated deficiency on endurance preobese obese IL-6-deficient (IL-6(-/-)) mice. Four-month-old 7-month-old IL-6(-/-) male backcrossed to C57BL/6 their littermate controls were exercised a treadmill, was...
Abstract Objectives There is currently widespread exposure to the toxic metal cadmium through diet as well smoking, and it has been suggested that may increase risk of cardiovascular disease. Here we examined whether associated with prevalence growth atherosclerotic plaques in carotid arteries. Design subjects The analyses were performed a screening‐based cohort 64‐year‐old Caucasian women stratified, random selection groups normal glucose tolerance, impaired tolerance diabetes ( n = 599)....