A5043661560- Neonatal Respiratory Health Research
- Neonatal and fetal brain pathology
- Preterm Birth and Chorioamnionitis
- Birth, Development, and Health
- Retinopathy of Prematurity Studies
- Infant Nutrition and Health
- Monoclonal and Polyclonal Antibodies Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Protein purification and stability
- Pregnancy and Medication Impact
- Ethics in Clinical Research
- Maternal Mental Health During Pregnancy and Postpartum
- Reproductive tract infections research
- Bioinformatics and Genomic Networks
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Fatty Acid Research and Health
- Cardiovascular Conditions and Treatments
- Metabolism and Genetic Disorders
- Advanced Proteomics Techniques and Applications
- Pelvic floor disorders treatments
- Glycosylation and Glycoproteins Research
- Metabolomics and Mass Spectrometry Studies
- Acute Kidney Injury Research
- Ethics in medical practice
- Neonatal Health and Biochemistry
Karolinska Institutet
2020-2024
Stockholm South General Hospital
2022-2024
Sachs' Children and Youth Hospital
2022-2024
AlbaNova
2015
KTH Royal Institute of Technology
2015
Abstract An important aspect of precision medicine is to probe the stability in molecular profiles among healthy individuals over time. Here, we sample a longitudinal wellness cohort with 100 and analyze blood including proteomics, transcriptomics, lipidomics, metabolomics, autoantibodies immune cell profiling, complemented gut microbiota composition routine clinical chemistry. Overall, our results show high variation between across different readouts, while intra-individual baseline low....
An important issue for the performance and specificity of an antibody is nature binding to its protein target, including if recognition involves linear or conformational epitopes. Here, we dissect polyclonal sera by creating epitope-specific fractions using a combination epitope mapping affinity capture approach involving both synthesized peptides recombinant fragments. This allowed us study relative amounts antibodies epitopes in as well ability each antibody-fraction detect target Western...
To assess the impact of gestational antibiotics on risk preterm birth, since a healthy maternal microbiome may be protective.Population-based cohort study including all first pregnancies in Sweden (2006-16). The association between and recent pre-conception systemic birth was assessed by multivariable logistic regression presented as ORs 95% CIs, adjusted for comorbidities (hypo- hyperthyroidism, hypertension, or diabetes mellitus pre-gestation), trimester, antibiotic class treatment...
Clinical trials supplementing the long-chain polyunsaturated fatty acids (LCPUFAs) docosahexaenoic acid (DHA) and arachidonic (AA) to preterm infants have shown positive effects on inflammation-related morbidities, but molecular mechanisms underlying these are not fully elucidated. This study aimed determine associations between DHA, AA, proteins during neonatal period in extremely infants.
is the most common nosocomial coagulase-negative staphylococci infection in preterm infants. Clinical signs of are often unspecific and novel markers to complement diagnosis needed. We investigated proteomic alterations mouse brain after
Abstract Background Nearly one in ten children is born preterm. The degree of immaturity a determinant the infant’s health. Extremely preterm infants have higher morbidity and mortality than term infants. One disease affecting extremely retinopathy prematurity (ROP), multifactorial neurovascular that can lead to retinal detachment blindness. advances omics technology opened up possibilities study protein expressions thoroughly with clinical accuracy, here used increase understanding...
Preterm birth is the leading cause of neonatal mortality and morbidity. Early diagnosis interventions are critical to improving clinical outcomes extremely premature infants. Blood protein profiling during first months life in preterm infants can shed light on role early extrauterine development provide an increased understanding maturation after underlying mechanisms prematurity-related disorders.We have investigated blood profiles development. The levels were analyzed using next generation...
Abstract Background Two risk factors for severe retinopathy of prematurity (ROP) in extremely preterm infants are thrombocytopenia and low levels arachidonic acid (AA) docosahexaenoic (DHA). To date, these have not been linked. Method Infants born < 28 weeks gestational age (GA) from 2016 to 2019 were randomized postnatal enteral AA/DHA supplementation or standard care (controls). Levels AA DHA, platelet counts ( 100 × 10 9 /L defined as thrombocytopenia) platelet-related proteins the...
Abstract Preterm birth is the leading cause of neonatal mortality and morbidity. Early diagnosis interventions are critical to improve clinical outcomes extremely premature infants. Here, we have investigated blood protein profiles during first months life in preterm infants shed light on role early extrauterine development. The levels were analyzed using “next generation profiling” 1335 serum samples, collected longitudinally at nine time points from full term (40 weeks postmenstrual age)...
Background: Preterm birth is the leading cause of neonatal mortality and morbidity. Even so, etiology multifactorial poorly understood. Blood protein profiling during first months life in preterm infants can shed light on role early extrauterine development provide an increased understanding maturation after extremely underlying mechanisms prematurity-related disorders.Methods: The cohort study based multicenter, open-label, randomized controlled trial MegaDonnaMega at intensive care unit...