A5035554566- Obesity, Physical Activity, Diet
- Metabolomics and Mass Spectrometry Studies
- Obstructive Sleep Apnea Research
- Nutritional Studies and Diet
- Pelvic floor disorders treatments
- Birth, Development, and Health
- Dental Health and Care Utilization
- Diet and metabolism studies
- Celiac Disease Research and Management
- Neuroscience of respiration and sleep
- School Health and Nursing Education
- Child Nutrition and Water Access
- Systemic Lupus Erythematosus Research
- Health disparities and outcomes
- Chronic Disease Management Strategies
- Health Promotion and Cardiovascular Prevention
- Microscopic Colitis
- Iron Metabolism and Disorders
- Urinary Bladder and Prostate Research
- Smoking Behavior and Cessation
- Parkinson's Disease Mechanisms and Treatments
- Dental Radiography and Imaging
- Rheumatoid Arthritis Research and Therapies
- Lipoproteins and Cardiovascular Health
- Neurological disorders and treatments
Umeå Plant Science Centre
2008-2024
Umeå University
2015-2024
Swedish University of Agricultural Sciences
2008-2022
Science for Life Laboratory
2020-2021
Center for Global Health
2012-2014
Faculty of Public Health
2006-2012
University Hospital of Umeå
2006-2011
Skellefteå Hospital
2011
Bassett Healthcare Network
2011
University of Gdańsk
2010
To evaluate the prevalence and predictive value of anti-cyclic citrullinated peptide (anti-CCP) antibodies in individuals who subsequently developed rheumatoid arthritis (RA) to determine relationship factor (RF) any isotype.A case-control study was nested within Northern Sweden Health Disease Study Maternity cohorts Sweden. Patients with RA were identified among blood donors whose samples had been taken years before onset symptoms. Control subjects matched for age, sex, date sampling,...
Significance This study is the first multimalaria model intercomparison exercise. carried out to estimate impact of future climate change and population scenarios on malaria transmission at global scale provide recommendations for future. Our results indicate that might become more suitable in tropical highland regions. However, other important socioeconomic factors such as land use change, growth urbanization, migration changes, economic development will have be accounted further details...
Dengue is a mosquito-borne viral disease that occurs mainly in the tropics and subtropics but has high potential to spread new areas. infections are climate sensitive, so it important better understand how changing factors affect for geographic future dengue epidemics. Vectorial capacity (VC) describes vector's propensity transmit taking into account human, virus, vector interactions. VC highly temperature dependent, most models only take mean values account. Recent evidence shows diurnal...
<h3>Background</h3> Sleep apnea occurs frequently among patients with stroke, but it is still unknown whether a diagnosis of sleep an independent risk factor for mortality. We aimed to investigate obstructive or central was related reduced long-term survival stroke. <h3>Methods</h3> Of 151 admitted in-hospital stroke rehabilitation in the catchment area Umeå from April 1, 1995, May 1997, 132 underwent overnight recordings at mean (SD) 23 (8) days after onset All were followed up...
Sweden experienced a marked epidemic of celiac disease between 1984 and 1996 in children younger than 2 years age, partly explained by changes infant feeding. The objective this study was to determine the prevalence 12-year-olds born during (1993), including both symptomatic screening detected cases.All sixth-grade participating schools were invited (n = 10,041). Symptomatic and, therefore, previously diagnosed cases ascertained through National Swedish Childhood Celiac Disease Register...
To examine the association between 25-hydroxyvitamin D (25[OH]D) levels and risk of multiple sclerosis (MS) in blood samples collected prospectively during gestation.In this nested case-control study, 2 population-based biobanks with 291,500 from 164,000 persons since 1975 northern half Sweden were used. We identified MS cases (n = 192, controls matched 2:1) gestational pregnant mothers where offspring had later developed 37, control 5:1). 25(OH)D measured using an ELISA, was analyzed...
Warming temperatures may increase the geographic spread of vector-borne diseases into temperate areas. Although a tropical mosquito-borne viral disease, dengue outbreak occurred in Madeira, Portugal, 2012; first Europe since 1920s. This emphasizes potential for re-emergence given changing climates. We present estimates epidemic using vectorial capacity (VC) based on historic and projected temperature (1901–2099). VC indicates vectors' ability to disease among humans. calculated...
Antibodies against cyclic citrullinated peptide (CCP) and rheumatoid factors (RFs) have been demonstrated to predate the onset of arthritis (RA) by years. A nested case-control study was performed within Northern Sweden Health Disease cohort analyse presence shared epitope (SE) genes, defined as HLA-DRB1*0404 or DRB1*0401, anti-CCP antibodies RFs in individuals who subsequently developed RA. Patients with RA were identified from among blood donors whose samples had collected years before...
The effect of sleep apnea on mortality and cardiovascular morbidity is mainly unknown. We aimed to study whether related stroke, death, or myocardial infarction in patients with symptomatic coronary artery disease.A total 392 men women disease referred for angiography were examined by use overnight recordings. Sleep apnea, defined as an apnea-hypopnea index >or=5, was recorded 54% the patients. All followed up prospectively 10 years, no one lost follow-up. Stroke occurred 47 (12%) during...
This prospective, multicentre, randomized, double-blind and placebo controlled study was performed to describe the natural course of uncomplicated lower urinary tract infection (UTI). A total 1143 women 18 y above, consulting at primary health care centres in northern Sweden for symptoms suggestive UTI were included. The urgency, dysuria, suprapubic pain loin registered, urine cultures inclusion follow-up visits 8–10 d 5–7 weeks later. Associations between all bacteriuria or bacterial counts...
The study aims to describe the frequency, pattern and determinants of cognitive function in patients with newly diagnosed Parkinson's disease (PD); compare impaired cognition intact cognition; matched healthy controls.Patients were identified a longitudinal population based idiopathic non-drug induced parkinsonism. Eighty-eight PD no dementia included during four year period. 30 age- sex-matched control subjects underwent comprehensive neuropsychological assessment.Patients performed...
The objectives were (1) to assess caries development, including the incidence and rate of lesion progression, in a Swedish cohort from adolescence young adulthood (2) compare rates adolescents with those adults. original material consisted 536 children aged 11–13 years at baseline. This had been followed through annual bitewing radiographs 21–22 age. In 1998–1999, 250 these individuals re-examined age 26–27, new data added data. results showed that fewer enamel lesions developed on...
The presence of antibodies against cyclic citrullinated peptides has been demonstrated to precede the onset symptoms rheumatoid arthritis (RA) by several years. aim this study was analyze 10 autoantigen-derived for reactivity before RA symptoms.A case-control conducted within Medical Biobank Northern Sweden. performed in 409 individuals, 386 whom donated 717 blood samples (pre-patients). median period time predating 7.4 A total 1,305 population-based control subjects were also studied....
Most mass spectrometry based metabolomics studies are semiquantitative and depend on efficient normalization techniques to suppress systematic error. A common approach is include isotope-labeled internal standards (ISs) then express the estimated metabolite abundances relative IS. Because of problems such as insufficient chromatographic resolution, however, analytes may directly influence estimates IS, a phenomenon known cross-contribution (CC). Normalization using ISs that suffer from CC...
Obstructive sleep apnoea (OSA) is primarily regarded as a male disorder, presenting with snoring, daytime sleepiness and cardiovascular disease. We aimed to determine the frequency of among females in general population. investigated 400 from population-based random sample 10,000 aged 20–70 yrs. They answered questionnaire performed overnight polysomnography. OSA (apnoea/hypopnoea index (AHI) ≥5) was found 50% (95% CI 45–55%) Sleep related age, obesity hypertension, but not sleepiness....
To evaluate the effect of a mobile app treatment for stress urinary incontinence (SUI) in women.Randomized controlled trial, conducted 2013-2014 Sweden. Community-dwelling adult women with ≥1 SUI episode/week recruited through our website and randomized to (n = 62) or control group (postponed treatment, n 61). One participant from each was lost follow-up. Intervention Tät® program focused on pelvic floor muscle training (PFMT), information about lifestyle factors. Primary outcomes, 3 months...
Objective. To analyse associations between symptoms and bacteriuria in uncomplicated lower urinary tract infection women (LUTIW) to evaluate outcome of therapy with three different regimens pivmecillinam or placebo. Design. Prospective, multicentre, randomized, double-blind, placebo-controlled study. Symptoms registered at inclusion, during follow-up visits after 8–10 35–49 days. Significant defined according current European guidelines. Setting. A total 18 primary healthcare centres...
Aims To determine whether changes in questionnaire scores on symptoms and condition-specific quality of life reflect clinically relevant improvements women with stress urinary incontinence (SUI). Methods We retrospectively analyzed questionnaires collected during a randomized controlled trial SUI, that received pelvic floor muscle training (PFMT) two different formats. included 218 answered validated self-assessment at baseline 4-month follow-up. registered questionnaires, the International...
Abstract An important aspect of precision medicine is to probe the stability in molecular profiles among healthy individuals over time. Here, we sample a longitudinal wellness cohort with 100 and analyze blood including proteomics, transcriptomics, lipidomics, metabolomics, autoantibodies immune cell profiling, complemented gut microbiota composition routine clinical chemistry. Overall, our results show high variation between across different readouts, while intra-individual baseline low....