Sweden experienced a marked epidemic of celiac disease between 1984 and 1996 in children younger than 2 years age, partly explained by changes infant feeding. The objective this study was to determine the prevalence 12-year-olds born during (1993), including both symptomatic screening detected cases.All sixth-grade participating schools were invited (n = 10,041). Symptomatic and, therefore, previously diagnosed cases ascertained through National Swedish Childhood Celiac Disease Register...

OBJECTIVES: Between 1984 and 1996, Sweden experienced an “epidemic” of clinical celiac disease in children <2 years age, attributed partly to changes infant feeding. Whether feeding affects occurrence and/or the presentation remains unknown. We investigated compared total prevalence 2 birth cohorts 12-year-olds related findings each cohort’s ascertained METHODS: A 2-phase cross-sectional screening study was performed which 13 279 from participated: born during epidemic (1993) after...

Alterations in the composition of microbiota intestine may promote development celiac disease (CD). Using scanning electron microscopy (SEM) we previously demonstrated that rod-shaped bacteria were present on epithelium proximal small children with CD but not controls. In this study characterize and controls identify CD-associated bacteria.Proximal biopsies from 45 18 clinical studied. Bacteria identified by 16S rDNA sequencing DNA extracted washed buffer containing dithiothreitol to enrich...

To determine how the delay in diagnosing celiac disease (CD) has developed during recent decades and this affects burden of terms health-related quality life (HRQoL), also to consider differences with respect sex age. In collaboration Swedish Society for Coeliacs, a questionnaire was sent 1,560 randomly selected members, divided equal-sized age- strata, 1,031 (66%) responded. HRQoL measured EQ-5D descriptive system then translated quality-adjusted year (QALY) scores. A general population...

To describe the frequency of symptoms and associated conditions among screening-detected celiac disease (CD) cases non-CD children to evaluate questionnaire-based case-finding targeting general population.In a population-based CD screening 12-year-olds, their parents completed questionnaires on CD-associated before knowledge status. Questionnaire data for those who had detected in (n = 153) were compared with normal levels markers 7016). Hypothetical strategies also evaluated. Questionnaires...

A hallmark of active celiac disease (CD), an inflammatory small-bowel enteropathy caused by permanent intolerance to gluten, is cytokine production intestinal T lymphocytes. Prerequisites for contracting CD are that the individual carries MHC class II alleles HLA-DQ2 and/or HLA-DQ8 and exposed gluten in diet. Dysbiosis resident microbiota has been suggested be another risk factor CD. In fact, rod shaped bacteria adhering small mucosa were frequently seen patients with during “Swedish...

Purpose: The Swedish National Patient Register (NPR) is often used in observational studies of childhood-onset inflammatory bowel disease (IBD) (< 18 years age) and its subtypes, but the validity previously register-based algorithms for capturing IBD has never been examined. Methods: We identified a random sample 233 individuals with at least two first ever diagnostic listings NPR between 2002 2014. calculated test characteristics different definitions subtypes using Copenhagen criteria...

Growth and reproductive capacity in perch (Percafluviatilia L.) roach (Rutilusrutilus (L.)) were studied during 1983, 1984 1985 a coastal area of the Bothnian Sea affected by bleached pulp mill effluents. Comparative investigations made at producing unbleached pulp. In exposed to bleachery effluents effects observed on length increase rates, somatic condition factors gonad development. The fraction fishes displaying inhibited gonadal recrudescence was high close mill, size developing gonads...

Population structure, recruitment, mortality, life expectancy, age at maturity, gonad development, fecundity, net reproductive rate and energy storage were studied in a perch population exposed to thermal discharge. The experiment was conducted during 1978–1990 an artificial enclosure nuclear power plant on the Baltic Sea coast. Abundance increased after started operating, although proportion of larger dropped low level. Recruitment improved, but adult mortality increased. This effect...

A gluten-free diet is the only available treatment for celiac disease. Our aim was to investigate effect of a on disease related symptoms, health care consumption, and risk developing associated immune-mediated diseases. questionnaire sent 1,560 randomly selected members Swedish Society Coeliacs, divided into equal-sized age- sex strata; 1,031 (66%) responded. Self-reported consumption (measured by visits hospitalization days), missed working days were reported both year prior diagnosis...

The aim of the present study was to evaluate any potential correlation between anti-tissue transglutaminase antibodies type immunoglobulin A (tTG-IgA) and degree gluten-induced enteropathy in children participating a screening for celiac disease (CD) assess what extent revised European Society Pediatric Gastroenterology, Hepatology, Nutrition (ESPGHAN) guidelines cover this group patients.The is substudy cross-sectional CD study, Exploring Iceberg Celiacs Sweden, 2-phased performed during...

ABSTRACT Objectives: The aim of this study was to evaluate hypothetical screening strategies in a Swedish celiac disease (CD) mass screening. Methods: Of 10,041 sixth graders born 1993 invited population‐based CD screening, 7208 participated. Anti‐tissue transglutaminase (tTG) immunoglobulin (Ig) A were analyzed all children and total serum IgA (s‐IgA) 7161 children. Additional analyses tTG‐IgG, endomysial antibodies (EMA) IgG, human leukocyte antigen (HLA) alleles performed according...

The aim of the study was to evaluate gluten-free diet (GFD) adherence after 1 year follow-up in children with screening-detected celiac disease (CD) a general population.A total 18,325 twelve-year-olds were invited participate population-based CD screening (Exploring Iceberg Celiacs Sweden), whom 13,279 participated. In 240 children, detected through elevated anti-tissue transglutaminase antibodies 2 (TG2-IgA) and verified by small-intestinal biopsy. This substudy included 210 TG2-IgA,...

Celiac disease is a chronic inflammatory of the small intestine mucosa due to permanent intolerance dietary gluten. The aim was elucidate role intestinal epithelial cells in immunopathology celiac particular influence disease-associated bacteria.Duodenal biopsies were collected from children with active disease, treated and clinical controls. Intestinal purified analyzed for gene expression changes at mRNA protein levels. Two vitro models human epithelium, enteroids polarized tight...

High temperature in Swedish and Lithuanian thermal effluent areas influenced gametogenesis of female perch Perca fluviatilis , roach Rutilus rutilus pike Esox lucius negatively, indicating reduced reproductive capacity. Oocyte atresia started during vitellogenesis autumn, was often followed by asynchronous egg cell development. Among other anomalies, multi‐nucleus oocytes hermaphroditism were observed. No significant impact seen silver bream Blicca bjoerkna . Ruffe Gymnocephalus cernuus...

Celiac disease (CD) is a major public health problem with estimated 1-3% prevalence in the general population. In recent years an increase CD has been reported both Sweden and worldwide. This study aimed at examining annual incidence rate of biopsy-proven celiac among children over 36-year period, to assess variations by age, sex birth cohort, clinical impact these changes. The National Swedish Childhood Register was used identify 9107 aged 0–14.9 who were diagnosed during period 1973 2009....

Between 1982 and 1987, many abnormalities were reported in a Baltic coastal fish community exposed to bleached kraft mill effluent. Perch (Perca fluviatilis) was selected as sentinel species. Local recruitment significantly reduced owing high larval mortality associated with gonad malfunctions low embryo quality. Adult abundance near the outfall poor After 1984, toxicity of effluent by substituting chlorine dioxide for molecular which resulted lower amounts organochlorine waste, while other...

The dynamics of a Baltic perch (Perca fluviatilis) population were studied in bleached pulp mill effluent area on the Swedish coast. Recruitment was seriously affected, as larval and fry abundances very low. Studies spawning artificial substrates demonstrated that sufficient numbers eggs deposited even most effluent-exposed parts study area. No increased egg mortality could be noted, but at stage close to hatching about 10% embryos observed malformed, generally having sharp bends posterior...

Abstract The first attempts to monitor coastal fish in Sweden were made the 1960s and 1970s. Ecological, physiological, biochemical environmental chemistry data collected separate projects. When National Marine Monitoring Programme was revised 1992, a new strategy introduced for assessments of long-term trends communities. Annual integrated monitoring contaminants, biomarkers population community indicators ecosystem health started selected areas using common sentinel species. Data from one...