A5000157094- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Malaria Research and Control
- Esophageal Cancer Research and Treatment
- Lung Cancer Treatments and Mutations
- COVID-19 epidemiological studies
- Gastric Cancer Management and Outcomes
- Zoonotic diseases and public health
- Dengue and Mosquito Control Research
- Indigenous Studies and Ecology
- Agricultural risk and resilience
- Complementary and Alternative Medicine Studies
- Animal Disease Management and Epidemiology
- Vector-borne infectious diseases
- Viral gastroenteritis research and epidemiology
- Esophageal and GI Pathology
- Health, psychology, and well-being
- Insect symbiosis and bacterial influences
- Lung Cancer Diagnosis and Treatment
- Viral Infections and Immunology Research
Umeå University
2014-2021
Dengue is a mosquito-borne viral disease that occurs mainly in the tropics and subtropics but has high potential to spread new areas. infections are climate sensitive, so it important better understand how changing factors affect for geographic future dengue epidemics. Vectorial capacity (VC) describes vector's propensity transmit taking into account human, virus, vector interactions. VC highly temperature dependent, most models only take mean values account. Recent evidence shows diurnal...
Warming temperatures may increase the geographic spread of vector-borne diseases into temperate areas. Although a tropical mosquito-borne viral disease, dengue outbreak occurred in Madeira, Portugal, 2012; first Europe since 1920s. This emphasizes potential for re-emergence given changing climates. We present estimates epidemic using vectorial capacity (VC) based on historic and projected temperature (1901–2099). VC indicates vectors' ability to disease among humans. calculated...
In 2012, Madeira reported its first major outbreak of dengue. To identify the origin imported dengue virus, we investigated interconnectivity via air travel between dengue-endemic countries and Madeira, compared available sequences against GenBank. There were 22,948 travellers to in originating from twenty-nine countries; 89.6% these international originated Venezuela Brazil. We developed an importation index that takes into account both volume extent incidence country origin. Brazil had by...
The explosive Zika virus epidemic in the Americas is amplifying spread of this emerging pathogen into previously unaffected regions world, including Europe (Gulland, 2016), where local populations are immunologically naïve. As summertime approaches northern hemisphere, Aedes mosquitoes may find suitable climatic conditions to acquire and subsequently transmit from viremic travellers populations. While albopictus has proven be a vector for transmission dengue chikungunya viruses (Delisle et...
Background:Aedes aegypti is the principal vector for several important arbovirus diseases, including dengue, chikungunya, yellow fever, and Zika. While recent empirical research has attempted to identify current global distribution of vector, seasonal, longer-term dynamics mosquito in response trends climate, population, economic development over twentieth twenty-first century remains be elucidated. Methods: In this study, we use a process-based mathematical model estimate abundance. The...
Climate change allows Aedes aegypti to infest new areas. Consequently, it enables the arboviruses mosquito transmits -- e.g., dengue, chikungunya, Zika and yellow fever - emerge in previously uninfected An example is Portuguese island of Madeira during 2012-13.We aim understand how climate will affect future spread this potent vector, as an aid assessing risk disease outbreaks effectively allocating resources for vector control.We used empirically-informed, process-based mathematical model...
Given the speed of air travel, diseases even with a short viremia such as dengue can be easily exported to naïve areas within 24 hours. We set out estimate risk virus introductions via travelers into Europe and number secondary autochthonous cases result introduction. applied mathematical modeling dengue-viremic passengers from 16 dengue-endemic countries 27 European countries, taking account incidence in exporting travel volume probability being viremic at time travel. Our models range zero...
Dengue virus serotype 4 (DENV 4) has had a relatively low prevalence worldwide for decades; however, likely due to data paucity, no study investigated the epidemiology and evolutionary dynamics of DENV genotype I 4-I). This aims understand diversity, 4-I. We collected 404 full length DENV4-1 envelope (E) gene sequences from 14 countries using two sources: Yunnan Province in China (15 strains during 2013-2016) GenBank (489 up 2018-01-11). Conducting phylogenetic phylogeographical analyses, we...
Abstract Background Hand, foot, and mouth disease (HFMD) is a common illness in young children. A monovalent vaccine has been developed China protecting against enterovirus-71, bivalent vaccines preventing HFMD caused by two viruses are under development. Objective To predict compare the incidence of different vaccination scenarios China. Methods We compartmental model to capture enterovirus transmission natural history children aged 0–5, calibrated reported cases same age-group from 2015...
Introduction Dengue has become a more serious human health concern in China, with increased incidence and expanded outbreak regions. The knowledge of the cross-sectional longitudinal epidemiological characteristics evolutionary dynamics dengue high-risk areas China is limited. Methods Records cases from 2013 to 2016 were obtained Notifiable Disease Surveillance System. Full envelope gene sequences viruses detected collected. Maximum Likelihood tree haplotype network analyses conducted...
The current TNM classification system does not consider tumor length for patients with esophageal carcinoma (EC). This study explored the effect of length, in addition to depth and lymph node involvement, on survival squamous cell (ESCC).A total 498 ESCC who underwent surgical resection as primary treatment were selected retrospective study. Pathological details collected, which included type, stage, differentiation. Other collected information were: types resection, ABO blood group, family...
Abstract Background Clinically, there are no clear guidelines on the extent of lymphadenectomy in patients with T1 esophageal cancer. Studying minimum number lymph nodes for resection may increase cancer-specific survival. Methods Patients who underwent esophagectomy and at stage were selected from Surveillance, Epidemiology End Results Program (United States, 1998–2014). Maximally rank Cox proportional hazard models used to examine three variables: examined, negative node ratio....
Introduction Dengue is one of the most important vector-borne viral diseases. During last few decades a geographic expansion has been observed and first dengue outbreak in modern history Europe occurred Madeira, 2012. Dengue clinical presentation varies, with majority infections being asymptomatic. Despite its worldwide importance role asymptomatic transmission spread not well understood. This work aims at …