A5082849804- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Malaria Research and Control
- Zoonotic diseases and public health
- Salmonella and Campylobacter epidemiology
- Vibrio bacteria research studies
- Viral Infections and Outbreaks Research
- Antibiotic Resistance in Bacteria
- Vector-borne infectious diseases
- Microbial infections and disease research
- Dengue and Mosquito Control Research
- Enterobacteriaceae and Cronobacter Research
- Nutritional Studies and Diet
- Aquaculture disease management and microbiota
- SARS-CoV-2 and COVID-19 Research
- Insect symbiosis and bacterial influences
- COVID-19 epidemiological studies
- Bacterial Identification and Susceptibility Testing
- Viral gastroenteritis research and epidemiology
- Diet and metabolism studies
- Plant Virus Research Studies
- Escherichia coli research studies
- Herpesvirus Infections and Treatments
- Hypertrophic osteoarthropathy and related conditions
- Psidium guajava Extracts and Applications
World Health Organization Regional Office for the Americas
2022-2025
Universidade do Estado da Bahia
2024
Instituto Conmemorativo Gorgas de Estudios de la Salud
2016-2023
Universidade de São Paulo
2016-2023
Wadsworth Center
2023
Administración Nacional de Laboratorios e Institutos de Salud
2023
Instituto de Medicina Tropical “Pedro Kourí”
2023
Instituto Evandro Chagas
2023
Secretaria de Salud
2023
Faculdade de Medicina de São José do Rio Preto
2023
Usutu virus (USUV) is an African mosquito-borne flavivirus, member of the Japanese encephalitis antigenic group. This avian transmitted by arthropod vectors (mainly mosquitoes Culex pipiens complex). It well known that free-living birds, including migratory species, have potential to disperse certain pathogenic microorganisms. has recently been introduced Europe and spreading through Austria, Hungary, Italy, Spain Switzerland, causing disease in birds humans. Like West Nile virus, USUV may...
In 2012, Madeira reported its first major outbreak of dengue. To identify the origin imported dengue virus, we investigated interconnectivity via air travel between dengue-endemic countries and Madeira, compared available sequences against GenBank. There were 22,948 travellers to in originating from twenty-nine countries; 89.6% these international originated Venezuela Brazil. We developed an importation index that takes into account both volume extent incidence country origin. Brazil had by...
ABSTRACT A method for the rapid diagnosis of early dengue virus (DENV) infection is highly needed. Here, a prototype reverse transcription-recombinase polymerase amplification (RT-RPA) assay was developed. The detected DENV RNA in <20 min without need thermocycling amplification. enabled detection as few 10 copies RNA. designed RT-RPA primers and exo probe genome at least 12 genotypes circulating globally cross-reacting with other arboviruses. We assessed diagnostic performance 203 serum...
We used nanopore sequencing and phylogenetic analyses to identify a cosmopolitan genotype of dengue virus serotype 2 that was isolated from 56-year-old male patient the state Goiás in Brazil. The emergence Brazil will require risk assessment surveillance reduce epidemic potential.
Due to non-existing or limited surveillance in Africa, little is known about the epidemiology of dengue illness continent. Serological and virological data obtained from returning European travellers a key complement this often flawed information. In past years, 3 virus has emerged West Africa been detected Europe. The first epidemic Cape Verde with more than 17,000 cases September December 2009 demonstrated that still expanding worldwide new territories.
The spread of Chikungunya virus is a major public health concern in the Americas. There were >120,000 cases and 51 deaths 2023, which 46 occurred Paraguay. Using suite genomic, phylodynamic, epidemiologic techniques, we characterized ongoing large chikungunya epidemic
Abstract Latin America and Caribbean (LAC) regions were an important epicenter of the COVID-19 pandemic SARS-CoV-2 evolution. Through Genomic Surveillance Regional Network (COVIGEN), LAC countries produced number genomic sequencing data that made possible enhanced surveillance capacity in Americas, paving way for characterization emerging variants helping to guide public health response. In this study we analyzed approximately 300,000 sequences generated between February 2020 March 2022 by...
We describe the epidemiological pattern and genetic characteristics of 242 acute dengue infections imported to Europe by returning travellers from 2012 2014. The overall geographical (South-east Asia > Americas western Pacific region Africa) remained stable compared with 1999 2010. isolated majority virus genotypes epidemic lineages causing outbreaks epidemics in Asia, America Africa during study period. Travellers acted as sentinels for four unusual (Madeira, 2012-13; Luanda, 2013; Dar es...
The family Flaviviridae, genus Flavivirus, holds many of the world's most prevalent arboviral diseases that are also considered important travel related infections. In cases, flavivirus diagnosis in travelers is primarily based on serology as viremia often low and typically has already been reduced to undetectable levels when symptoms set patients seek medical attention. Serological differentiation between flaviviruses false-positive results caused by vaccination cross-reactivity among...
The timely release of SARS-CoV-2 first genomic sequences allowed the identification etiologic agent and development diagnostic protocols. Genomic sequencing was a crucial step in generating data for driving laboratory response detections since start COVID-19 pandemic. Because all progression achievements that genetic sequence represents public health response, Pan American Health Organization (PAHO) collaboration with countries’ laboratories, started implementation network strengthening...
In recent months, Paraguay has been grappled with a notable monkeypox outbreak, straining its healthcare infrastructure. The sudden spike in cases underlines the imperative need for comprehensive understanding of virus’s dynamics, enabling formulation robust containment measures. To address this challenge, our team joined forces Central Public Health Laboratory Asunción and Pan-American Organization. Through collaboration, we employed portable whole-genome sequencing combined phylodynamic...
Uruguay experienced its first Chikungunya virus outbreak in 2023, resulting a significant burden to healthcare system. We conducted analysis based on real-time genomic surveillance (30 novel whole genomes) offer timely insights into recent local transmission dynamics and eco-epidemiological factors behind emergence spread the country.
The TEM8 protein coded by the ANTXR1 gene represents an emerging biomarker in solid tumors. In addition to various roles plays oncogenesis, including angiogenesis, epithelial-to-mesenchymal transition, and cell migration, it has also been shown that overexpression of tumors correlates with poor prognostic indicators several tumor histologies. As such, identified as target novel oncologic therapies. It is especially attractive given its selective expression on surface cells associated stromal...
Dengue virus (DENV) circulates in human and sylvatic cycles. Sylvatic strains are both ecologically evolutionarily distinct from endemic viruses. Although dengue cycles occur West African countries Malaysia, only a few cases of mild disease caused by one single case hemorrhagic fever Malaysia have been reported. Here we report (DHF) with thrombocytopenia (13000/µl), raised hematocrit (32% above baseline) mucosal bleeding 27-year-old male returning to Spain November 2009 after visiting his...
Edwardsiella tarda infections are frequent causes of severe outbreaks in the fish farming industry besides representing possible zoonotic risks. However, naturally occurring that affect various species fishes seldom described.To report an outbreak acute mortality caused by E. affecting multiple inhabited a natural pond state São Paulo, Brazil.Three adult tilapias, three Mallard ducks and one Snow egret were necropsied subjected to further microbiological tests. Gross microscopic lesions...
We employ a multidisciplinary approach, integrating genomics and epidemiology, to uncover recent dengue virus transmission dynamics in the Dominican Republic. Our results highlight previously unknown north-south pathway within country, with co-circulation of multiple lineages. Additionally, we examine historical climate data, revealing long-term trends towards higher theoretical potential for due rising temperatures. These findings provide information targeted interventions resource...
Abstract Paraguay has been severely affected by emergent Zika and chikungunya viruses, dengue virus is endemic. To learn more about the origins of genetic diversity epidemiologic history these viruses in Paraguay, we deployed portable sequencing technologies to strengthen genomic surveillance determine evolutionary epidemic arthropod-borne (arboviruses). Samples stored at National Central Laboratory were sequenced subjected phylogenetic analysis. Among 33 genomes generated, identified 2...
Ten cases of chikungunya were diagnosed in Spanish travellers returning from Haiti (n=2), the Dominican Republic (n=7) or both countries (n=1) between April and June 2014. These remind clinicians to consider European presenting with febrile illness arthralgia, who are Caribbean region Central America, particularly Republic. The presence Aedes albopictus together viraemic patients could potentially lead autochthonous transmission virus southern Europe.
An explosive epidemic occurred in Madeira Island (Portugal) from October 2012 to February 2013. Published data showed that dengue virus type 1 introduced South America was the incriminated virus. We aim determine origin of strain by travellers returning Europe. Using phylogeographic analysis and complete envelope sequences we have demonstrated most probable is Venezuela.