A5002805953- Resilience and Mental Health
- Gut microbiota and health
- Childhood Cancer Survivors' Quality of Life
- COVID-19 epidemiological studies
- Migration, Health and Trauma
- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Family Support in Illness
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Grief, Bereavement, and Mental Health
- Child Abuse and Trauma
- Veterinary Medicine and Surgery
- Chronic Obstructive Pulmonary Disease (COPD) Research
- COVID-19 and Mental Health
- Health disparities and outcomes
- Dietary Effects on Health
- Human-Animal Interaction Studies
- Family and Disability Support Research
- Obstructive Sleep Apnea Research
- Data-Driven Disease Surveillance
- Clostridium difficile and Clostridium perfringens research
- Adolescent and Pediatric Healthcare
- COVID-19 diagnosis using AI
Uppsala University
2018-2024
Science for Life Laboratory
2018-2023
Örebro University
2014-2019
Cancer Research And Biostatistics
2018
Örebro University Hospital
2017
Abstract Although development of microbiota in childhood has been linked to chronic immune-related conditions, early determinants have not fully elucidated. We used 16S rRNA sequencing analyse faecal and saliva samples from 83 children at four time-points during their first 2 years life mothers. Our findings confirm that gut infants low diversity highlight some properties are shared with the oral microbiota, although inter-individual differences present. A considerable convergence...
BackgroundPrevious population-based studies investigating the relationship between physical activity and gut microbiota have relied on self-reported activity, prone to reporting bias. Here, we investigated associations of accelerometer-based sedentary (SED), moderate-intensity (MPA), vigorous-intensity (VPA) with using cross-sectional data from Swedish CArdioPulmonary bioImage Study.MethodsIn 8416 participants aged 50–65, time in SED, MPA, VPA were estimated hip-worn accelerometer. Gut was...
Background: Adverse childhood experiences (ACEs) have consistently been associated with elevated risk of multiple adverse health outcomes, yet their contribution to coping ability and psychiatric resilience in adulthood is unclear. Methods: Cross-sectional data were derived from the ongoing Stress-And-Gene-Analysis cohort, representing 30% Icelandic nationwide female population, 18–69 years. Participants current study 26,198 women on 13 ACEs measured ACE-International Questionnaire....
Abstract The app-based COVID Symptom Study was launched in Sweden April 2020 to contribute real-time COVID-19 surveillance. We enrolled 143,531 study participants (≥18 years) who contributed 10.6 million daily symptom reports between 29, and February 10, 2021. Here, we include data from 19,161 self-reported PCR tests create a symptom-based model estimate the individual probability of symptomatic COVID-19, with an AUC 0.78 (95% CI 0.74–0.83) external dataset. These probabilities are employed...
Abstract Early life determinants of the oral microbiota have not been thoroughly elucidated. We studied association birth and early childhood characteristics with composition using 16 S ribosomal RNA (rRNA) gene sequencing in a population-based Swedish cohort 59 children sampled at 6, 12 24 months age. Repeated-measurement regression models adjusted for potential confounders confirmed expanded previous knowledge about profound shift life. These alterations included increased alpha diversity,...
Background Stress resilience is recognised as a determinant of both psychiatric and somatic health, but the potential link between stress cancer development has not been explored. Methods In this nationwide cohort study, we examined association in adolescence subsequent risk. We identified 284 257 Swedish men, born 1952–1956, who underwent compulsory military enlistment examinations including measures psychological (median age 18 years). The resulting score was categorised low, moderate high...
Background While compromised stress resilience constitutes a recognised risk factor for somatic and psychiatric disease development in general, the knowledge about how individual variation vulnerability to may specifically influence long-term risks of disadvantageous health behaviours is limited. Methods In this Swedish cohort study, we aimed investigate association between late adolescence adult use addictive substances. We included 9381 men with information on psychological measured during...
Abstract Objective To investigate whether dog and cat owners their pets share a risk of developing diabetes. Design Cohort study. Setting Register based longitudinal study, Sweden. Participants 208 980 owner-dog pairs 123 566 owner-cat identified during baseline assessment period (1 January 2004 to 31 December 2006). Main outcome measures Type 2 diabetes events in pets, including date diagnosis the follow-up 2007 2012). Owners with type were by combining information from National Patient...
Obesity is associated with adverse health outcomes, but the metabolic effects have not yet been fully elucidated. We aimed to investigate association between adiposity and circulating metabolites address causality Mendelian randomization (MR). Metabolomics data were generated nontargeted ultraperformance liquid chromatography coupled time-of-flight mass spectrometry in plasma serum from three population-based Swedish cohorts: ULSAM (N = 1,135), PIVUS 970), TwinGene 2,059). assessed...
ABSTRACT BACKGROUND Disruptions in gut microbiota have been implicated cardiometabolic disorders and other health outcomes. Antibiotics are known disruptors, but their long-term consequences on taxonomic composition of the microbiome remain underexplored. M ethods We investigated associations between register-based oral antibiotic use over 8 years assessed with fecal shotgun metagenomics 15,131 adults from Swedish population-based studies SCAPIS, MOS, SIMPLER. applied multivariable...
A parental cancer diagnosis is a stressful life event, potentially leading to increased risks of mental and physical problems among children. This study aimed investigate the associations with IQ, stress resilience, fitness affected men during early adulthood.In this Swedish population-based study, we included 465,249 born 1973-1983 who underwent military conscription examination around age 18 years. We identified diagnoses parents these from Cancer Register. were assessed at time...
Diagnostic testing is essential for disease surveillance and test-trace-isolate efforts. We aimed to investigate if residential area sociodemographic characteristics test accessibility were associated with Coronavirus Disease 2019 (COVID-19) rates.
This article investigates the impact of a non-mandatory and age-specific social distancing recommendation on isolation behaviours disease outcomes in Sweden during first wave coronavirus 2019 (COVID-19) pandemic (March to July 2020). The policy stated that people aged 70 years or older should avoid crowded places contact with outside household.We used regression discontinuity design-in combination self-reported data from COVID Symptom Study (n = 96 053; age range: 39-79 years) national...
Previous spatio-temporal COVID-19 prediction models have focused on the of subsequent number cases, and shown varying accuracy lack high geographical resolution. We aimed to predict trends in test positivity, an important marker for planning local testing capacity accessibility. included a full year information (June 29, 2020-July 4, 2021) with both direct indirect indicators transmission, e.g. mobility data, calls national healthcare advice line vaccination coverage from Uppsala County,...
Abstract Aims/hypothesis Parenting a child with type 1 diabetes has been associated stress-related symptoms. This study aimed to elucidate the potential impact on parental risk of major cardiovascular events (MCE) and death. Methods In this register-based study, we included parents 18,871 children, born 1987–2020 diagnosed in Sweden at <18 years. The median age child's diagnosis was 39.0 41.0 years for mothers fathers, respectively. cohort also encompassed 714,970 population-based matched...
Abstract Early reports raised concern that use of non-steroidal anti-inflammatory drugs (NSAIDs) may increase risk severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19). Users the COVID Symptom Study smartphone application reported aspirin and other NSAIDs between March 24 May 8, 2020. were queried daily about symptoms, COVID-19 testing, healthcare seeking behavior. Cox proportional hazards regression was used to determine among according or non-aspirin NSAID users....
ABSTRACT The app-based COVID Symptom Study was launched in Sweden April 2020 to contribute real-time COVID-19 surveillance. We enrolled 143,531 study participants (≥18 years) who contributed 10.6 million daily symptom reports between 29, and February 10, 2021. Data from 19,161 self-reported PCR tests were used create a symptom-based model estimate the individual probability of symptomatic COVID-19, with an AUC 0.78 (95% CI 0.74–0.83) external dataset. These probabilities regional prevalence,...
Abstract Obstructive sleep apnea (OSA) is a common sleep-related breathing disorder. In animal models, OSA has been shown to alter the gut microbiota; however, little known about such effects in humans. Here, we used respiratory polygraphy data from 3,570 individuals aged 50–64 Swedish CardioPulmonary bioImage Study (SCAPIS) and deep shotgun metagenomics identify OSA-associated microbiota features. We found that OSA-related hypoxia parameters were associated with 128 bacterial species,...
In brief: Owners of dogs which have with diabetes are more likely to develop T2DM themselves than owners without diabetes. The underlying mechanisms might include shared diabetogenic health behaviours and environmental exposures. No risk was found between cat their cats.
Obesity is associated with adverse health outcomes, but the metabolic effects have not yet been fully elucidated. We aimed to investigate association between adiposity circulating metabolites and address causality Mendelian randomization (MR). Metabolomics data was generated by non-targeted ultra-performance liquid-chromatography coupled time-of-flight mass-spectrometry in plasma serum from three population-based Swedish cohorts: ULSAM (N=1,135), PIVUS (N=970), TwinGene (N=2,059). assessed...