A5082304336- Obesity, Physical Activity, Diet
- Children's Physical and Motor Development
- Maternal Mental Health During Pregnancy and Postpartum
- Pregnancy and Medication Impact
- Cardiovascular Health and Risk Factors
- Birth, Development, and Health
- Maternal and Perinatal Health Interventions
- Physical Activity and Health
- Pharmacological Effects and Toxicity Studies
- Health disparities and outcomes
- Pregnancy and preeclampsia studies
- Health, Environment, Cognitive Aging
- Infant Development and Preterm Care
- Health Systems, Economic Evaluations, Quality of Life
- Advanced Causal Inference Techniques
- Cardiovascular and exercise physiology
- School Health and Nursing Education
- Pelvic floor disorders treatments
- Inclusion and Disability in Education and Sport
- Research in Social Sciences
- Global Maternal and Child Health
- Cardiovascular Disease and Adiposity
- Gestational Diabetes Research and Management
- Hip and Femur Fractures
- Bone health and osteoporosis research
Karolinska Institutet
2019-2025
Aarhus University
2024
Uppsala University
2024
Medical Research Council
2023-2024
University of Bristol
2023-2024
Karolinska Institutet Innovations (Sweden)
2022
Importance Several studies suggest that acetaminophen (paracetamol) use during pregnancy may increase risk of neurodevelopmental disorders in children. If true, this would have substantial implications for management pain and fever pregnancy. Objective To examine the associations with children’s autism, attention-deficit/hyperactivity disorder (ADHD), intellectual disability. Design, Setting, Participants This nationwide cohort study sibling control analysis included a population-based...
Abstract The teratogenic potential of valproate in pregnancy is well established; however, evidence regarding the long-term safety other antiseizure medications (ASMs) during remains limited. Using routinely collected primary care data from UK and nationwide Swedish registries to create a cohort 3,182,773 children, which 17,495 were exposed ASMs pregnancy, we show that those more likely receive diagnosis autism, intellectual disability, ADHD, when compared children not ASMs. Additionally,...
Objectives To examine the associations between physical fitness in male adolescents and coronary carotid atherosclerosis middle age. Methods This population-based cohort study linked data from Swedish Military Conscription Register during adolescence to CArdioPulmonary bioImage Study Cardiorespiratory was assessed using a maximal cycle-ergometer test, knee extension muscular strength evaluated through an isometric dynamometer. Coronary via Computed Tomography Angiography (CCTA) stenosis...
Background The relationship between statin treatment and Coronavirus Disease 2019 (COVID-19) mortality has been discussed due to the pleiotropic effects of statins on coagulation immune mechanisms. However, available observational studies are hampered by study design flaws, resulting in substantial heterogeneity ambiguities. Here, we aim determine COVID-19 mortality. Methods findings This cohort included all Stockholm residents aged 45 or older ( N = 963,876), followed up from 1 March 2020...
Background Intrahepatic cholestasis of pregnancy (ICP) is the most common obstetric liver disorder and associated with an increased risk iatrogenic preterm birth adverse infant outcomes. Hence, there are several plausible pathways through which ICP could affect offspring neurodevelopment. However, to best our knowledge, no studies have investigated these associations. Thus, we aimed determine whether neurodevelopmental conditions. Methods findings In this Swedish register-based cohort study,...
Abstract Purpose To monitor cardiovascular health, in 2022, the American Heart Association (AHA) updated construct “Life’s Simple 7” (LS7) to Essential 8” (LE8). This study aims analyze associations and capacity of discrimination LE8 LS7 relation self-rated health (SRH) health-related quality life (HRQoL). Methods from Swedish CArdioPulmonary bioImage Study (SCAPIS) included 28 731 participants, aged 50–64 years. Three different scores were derived SF-12 questionnaire: 1-item question SRH...
To examine the associations between American Heart Association scores ("Life's Essential 8" [LE8] and "Life's Simple 7" [LS7]) 2 subclinical coronary atherosclerosis indicators: computed tomographic angiography (CCTA)-stenosis artery calcium (CAC).
To quantify cardiovascular health (CVH), the American Heart Association (AHA) recently launched an updated construct of "Life's Simple 7" (LS7) score, Essential 8" (LE8) score. This study aims to analyse association between both CVH scores and carotid artery plaques compare predictive capacity such for plaques.Randomly recruited participants aged 50-64 years from Swedish CArdioPulmonary bioImage Study (SCAPIS) were analysed. According AHA definitions, two calculated: i) LE8 score (0, worst...
Abstract Objective: To examine the association between adolescent cardiorespiratory fitness and future risk of incident depression dispensation antidepressants, while addressing role familial confounding. Methods: A nationwide cohort study with registry-linkage incorporating full sibling comparators, based on Swedish men who participated in mandatory military conscription examinations 1972 1995. Cardiorespiratory was estimated using a maximal ergometer bicycle test. Depression diagnosis...
Previous studies have suggested that cesarean section (CS) is associated with offspring overweight and obesity. However, few been able to differentiate between elective nonelective CS, which may differ in their maternal risk profile biological pathway. Therefore, we aimed examine the association differentiated forms of delivery CS obesity young adulthood.Using Swedish population registers, a cohort 97,291 males born 1982 1987 were followed from birth until conscription (median 18 years age)...
Abstract Objective To examine antiseizure medication (ASM) prescription during pregnancy. Design Population‐based drug utilisation study. Setting UK primary and secondary care data, 1995–2018, from the Clinical Practice Research Datalink GOLD version. Population or Sample 752 112 completed pregnancies among women registered for a minimum of 12 months with an ‘up to standard’ general practice prior estimated start pregnancy duration their Methods We described ASM across study period, overall...
Background Antiseizure medications (ASMs) during the first trimester of pregnancy have been associated with an increased risk miscarriage. Methods We carried out a population-based cohort study using routinely collected healthcare data from UK, 1995–2018. Pregnancies were identified in Clinical Practice Research Datalink and we estimated HR miscarriage prescriptions ASMs pregnancy, Cox regression, adjusting for potential confounders, including ASM indications. Results prescribed 7832 (0.8%)...
Background Cardiorespiratory fitness has been linked to both lower and higher risks of cancer, but the evidence comes from observational analysis which may be influenced by unobserved confounders bias processes. We aimed examine associations between adolescent cardiorespiratory risk cancer in late adulthood while addressing unknown influence familial diagnostic Methods findings conducted a sibling-controlled cohort study with registry linkage based on all Swedish men who participated...
Background Psychiatric comorbidities are common in patients with epilepsy. Reasons for the co-occurrence of psychiatric conditions and epilepsy remain poorly understood. Aim We aimed to triangulate relationship between determine extent possible origins these conditions. Methods Using nationwide Swedish health registries, we quantified lifetime prevalence disorders then used summary data from genome-wide association studies investigate whether identified observational associations could be...
Objective The aim of this study was to investigate the association between preschool playground size, formalized physical activity (PA) policies, time spent outdoors and teacher's levels PA children's objectively assessed sedentary (ST) during hours. Methods In total, 369 children 84 teachers from 27 preschools in Södermalm municipally, Stockholm Sweden wore an Actigraph GT3X+ accelerometer 7 consecutive days. Preschool environmental structural characteristics were measured via Environment...
Abstract Low birth weight is associated with a lower grip strength later in life. However, associations between among infants born at-term and factors driving are largely unknown. A cohort of 144,369 young men at-term, including 10,791 individuals who had at least one male sibling/s, were followed until conscription where they performed test. We used linear non-linear regression analyses the full cohort, fixed-effects sibling to address confounding by that shared siblings. After adjustment,...
Both suicide and self-harm are disproportionately common in autistic people. Sex differences risk of observed the general population, but findings mixed for Self-cutting may be a particularly risky behaviour We aimed to explore sex method association between non-autistic adolescents young adults.
Importance Cardiovascular risk factors in youth have been associated with future cardiovascular disease (CVD), but conventional observational studies are vulnerable to genetic and environmental confounding. Objective To examine the role of shared by full siblings association adolescent CVD. Design, Setting, Participants This is a nationwide cohort study sibling comparisons. All men who underwent mandatory military conscription examinations Sweden between 1972 1995 were followed up until...
Abstract Background Participation in organized sports is associated with higher physical activity (PA) levels school-aged-children. Yet, little known about PA determinants preschool-aged-children. We examined associations between participation and preschoolers’ daily PA. Methods The study comprised 290 3–5 years old children was measured for 1 week via accelerometers. Organized parent-reported preschool arrival departure time teacher-recorded. duration reported by teachers matched...
The aim of the current study was to examine prevalence ideal cardiovascular health (iCVH) in general Swedish middle-aged population. To address this aim, we utilised data from CArdioPulmonary bioImage Study (SCAPIS) which is a large population-based (N=30,154) that combined comprehensive state-of-the-art imaging technology with clinical examinations and included all iCVH components. A total score calculated as number metrics at an level for seven components classified as: (⩾5 components),...
Background Preterm delivery and low birth weight are prospectively associated with cardiorespiratory fitness (CRF). However, whether weight, within the at-term range, is later CRF largely unknown. Thus, aim of current study was to examine this issue such association, if any, explained by shared and/or nonshared familial factors. Methods Results We conducted a prospective cohort study, including 286 761 young male adults subset 52 544 siblings born at-term. Objectively measured data were...