A5072784630- Corneal Surgery and Treatments
- Corneal surgery and disorders
- Ocular Surface and Contact Lens
- Intraocular Surgery and Lenses
- Glaucoma and retinal disorders
- Connexins and lens biology
- Photonic and Optical Devices
- Ocular Infections and Treatments
- Semiconductor Lasers and Optical Devices
- Retinal Diseases and Treatments
- Angiogenesis and VEGF in Cancer
- Periodontal Regeneration and Treatments
- Retinal Development and Disorders
- Allergic Rhinitis and Sensitization
- Ocular Diseases and Behçet’s Syndrome
- Advanced Fiber Optic Sensors
- Developmental Biology and Gene Regulation
- Lymphatic System and Diseases
- Optical Network Technologies
- Leech Biology and Applications
- Dialysis and Renal Disease Management
- Legionella and Acanthamoeba research
- Optical Imaging and Spectroscopy Techniques
- Dermatology and Skin Diseases
- Advanced Fiber Laser Technologies
Linköping University
2016-2025
Sørlandet Hospital Arendal
2019-2024
Linköping University Hospital
2008-2024
Sørlandet Sykehus
2024
Smart Eye (Sweden)
2015
European Union
2010
Marie Curie
2010
University of Ottawa
2006-2009
Ottawa Hospital
2008
The California Eye Institute
2007
A biosynthetic cornea is stably integrated with host tissues for 2 years after implantation and produces nerve regeneration vision improvement.
We developed cell-free implants, comprising carbodiimide crosslinked recombinant human collagen (RHC), to enable corneal regeneration by endogenous cell recruitment, address the worldwide shortage of donor corneas. Patients were grafted with RHC implants. Over four years, regenerated neo-corneas stably integrated without rejection, long immunosuppression regime needed cornea patients. There was no recruitment inflammatory dendritic cells into implant area, whereas, even immunosuppression,...
To develop a simple corneal substitute from cross-linked collagen.Porcine type I collagen (10%; pH 5), was mixed with 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) and N-hydroxysuccinimide (NHS). The final homogenous solution molded to dimensions, cured, then implanted into rabbits minipigs by lamellar keratoplasty. implants were followed for up 6 months after surgery. Clinical examinations of the cornea included detailed slit lamp biomicroscopy, in vivo confocal microscopy, topography...
Congenital aniridia is increasingly recognized as part of a complex syndrome with numerous ocular developmental anomalies and non-ocular systemic manifestations. This requires comprehensive care treatment affected patients. Our purpose was to analyze diseases in patients congenital within the Homburg Aniridia Registry. retrospective, monocentric study included who underwent ophthalmic examination at Saarland University Medical Center beginning June 2003. Age, gender, genetic test results,...
To compare the efficacies of recombinant human collagens types I and III as corneal substitutes for implantation.Recombinant collagen (13.7%) type or was thoroughly mixed with 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide N-hydroxysuccinimide. The final homogenous solution either molded into sheets in vitro studies implants appropriate dimensions transplantation minipigs. Animals were observed up to 12 months after surgery. Clinical examinations cornea included detailed slit lamp...
Loss of vision due to corneal disease or trauma affects over 10 million individuals worldwide. For many, trans-plantation is the only treatment, but supply good quality donor tissue cannot meet demand, especially in developing world. To address this need, several substitutes have been proposed;1, 2 however, date, clinically tested humans fully synthetic prostheses (keratoprostheses).3, 4 Although improving, complications with prostheses, including retroprosthetic membrane formation,...
To investigate morphologic alterations in the limbal palisades of Vogt a progressive form stem cell deficiency.Twenty Norwegian subjects (40 eyes) with congenital aniridia and 9 healthy family members (18 without were examined. Clinical grade aniridia-related keratopathy (ARK) was assessed by slit-lamp biomicroscopy, tear production quality, corneal thickness, sensitivity additionally measured. The superior inferior central cornea examined laser scanning vivo confocal microscopy (IVCM).In an...
We established a baseline value for central corneal subbasal nerve density in large, healthy cohort.A total of 106 volunteers (207 eyes) underwent full ophthalmic examination, including laser-scanning vivo confocal microscopy (IVCM) the cornea. Images plexus were acquired and analyzed based on defined criteria. Nerve tracing was performed by two human observers fully automated method. Subbasal stratified eye, observer, method, calculation age group. Association with examined linear...
Corneal neovascularization is a sight-threatening condition caused by angiogenesis in the normally avascular cornea. Neovascularization of cornea often associated with an inflammatory response, thus targeting VEGF-A alone yields only limited efficacy. The NF-κB signaling pathway plays important roles inflammation and angiogenesis. Here, we study consequences inhibition activation through selective blockade IKK complex IκB kinase β (IKK2) using compound IMD0354, focusing on effects...
Abstract Type 2 diabetes mellitus is characterized by a low-grade inflammation; however, mechanisms leading to this inflammation in specific tissues are not well understood. The eye can be affected diabetes; thus, we hypothesized that inflammatory changes the may parallel develops with diabetes. Here, developed non-invasive means monitor status of dendritic cell (DC) subsets corneal epithelium as potential biomarker for onset type In an age-matched cohort 81 individuals normal and impaired...
Biomaterials designed to replace the diseased cornea could be used treat corneal blindness where human donor tissue is in short supply, but challenges are integration of biomaterials with host and cells, avoiding a rapid material degradation maintaining transparency. Additionally, implantation surgery often triggers an aggressive wound healing response that can lead thinning opacity. Here, we report collagen-based hydrogel transparency mechanical properties suitable for replacing substantial...