A5017905716- Ocular Surface and Contact Lens
- Corneal Surgery and Treatments
- Allergic Rhinitis and Sensitization
- Glaucoma and retinal disorders
- Corneal surgery and disorders
- Salivary Gland Disorders and Functions
- Urticaria and Related Conditions
- Ocular Disorders and Treatments
- Connexins and lens biology
- Intraocular Surgery and Lenses
- Systemic Sclerosis and Related Diseases
- Retinal Development and Disorders
- Tissue Engineering and Regenerative Medicine
- Dermatology and Skin Diseases
- Olfactory and Sensory Function Studies
- Skin Protection and Aging
- Leech Biology and Applications
- Acne and Rosacea Treatments and Effects
- 3D Printing in Biomedical Research
- Facial Rejuvenation and Surgery Techniques
- Ocular Infections and Treatments
- Developmental Biology and Gene Regulation
- Neurobiology and Insect Physiology Research
- Retinal Diseases and Treatments
- Advanced Drug Delivery Systems
Oslo University Hospital
2015-2025
University of Oslo
2006-2019
Regenerative Medicine Institute
2014
Center for Clinical Research (United States)
2012
Massachusetts Eye and Ear Infirmary
2011-2012
Harvard University
2011-2012
Smith-Kettlewell Eye Research Institute
2011-2012
Ophthalmology Associates (United States)
2009
Eye Center
2007
There is a long-lasting need for non-invasive, more accurate diagnostic techniques when evaluating primary Sjögren's syndrome (pSS) patients. Incorporation of additional diagnostics involving screening disease-specific biomarkers in biological fluid promising concept that requires further investigation. In the current study we aimed to explore novel disease saliva and tears from pSS patients.Liquid chromatography-mass spectrometry (LC-MS) was performed on stimulated whole 27 patients 32...
Mononuclear cell infiltration of exocrine glands, production Ro/SSA and La/SSB autoantibodies, along with oral ocular dryness, are characteristic features primary Sjögren's syndrome (pSS). Non-SS sicca subjects, an underexplored group in relation to pSS, display similar symptoms, possible mild signs inflammation their salivary yet no serological detection autoantibody production. In this study, we investigated inflammatory manifestations the gland tissue, tear fluid saliva non-SS as compared...
Abstract Investigating cytokines in tear fluid and saliva may offer valuable information for understanding the pathogenesis of primary Sjögren’s syndrome (pSS). Cytokine profiles both pSS patients, non-Sjögren’s (non-SS) subjects with sicca symptoms, healthy controls without complaints were analysed. Furthermore, relationships associating severity clinical ocular oral manifestations upregulated assessed. In fluid, patients showed elevated levels IL-1ra, IL-2, IL-4, IL-8, IL-12p70, IL-17A,...
Purpose: To investigate the tear cytokine profile in congenital aniridia, and correlate levels with ophthalmologic findings. Methods: We examined 35 patients aniridia 21 healthy controls. Tear fluid was collected Schirmer I test capillary tubes from each eye, concentration of 27 inflammatory cytokines determined using multiplex bead assay. Eyes all participants were tests for dry eye disease, including evaluation meibomian glands (meibography). Differences between two groups analyzed,...
To classify subtypes of meibomian gland dysfunction (MGD) and evaluate the dependency dry eye signs, symptoms, parameters on MGD subtype.Cross-sectional study.the right eyes 447 patients with various 20 healthy volunteers.Patients were divided into 4 based meibum expression, quality, MG loss meibography images (meibograde 0-6). Subtypes high delivery (hypersecretory nonobvious MGD) those low (hyposecretory obstructive MGD). Additional clinical tests included tear film break-up time (TFBUT),...
Abstract The prevalence of dry eye disease is high worldwide and poses a great burden on patients’ daily lives. Accurate diagnosis the important, it requires application various methods. Hyperosmolarity believed to be marker thus measuring provides useful information. In this study we investigated utility tear osmolarity measured with TearLab osmometer, along other diagnostic tests (Ocular Surface Disease Index questionnaire, Tear film break-up time, Ocular Protection Index, Staining,...
Purpose: To investigate the association between PAX6 genotype and macular morphology in congenital aniridia. Methods: The study included 37 participants (15 males) with aniridia (aged 10–72 years) 58 age-matched normal controls (18 males). DNA was isolated from saliva samples. exons, intron/exon junctions, known regulatory regions were amplified PCR sequenced. Multiplex ligation-dependent probe amplification (MLPA) performed to detect larger deletions or duplications cis-regulatory regions....
Purpose: To determine the prevalence of dry eye disease (DED) in patients scheduled for cataract surgery a Norwegian clinic. Patients and Methods: 218 were examined DED one randomly selected questioned regarding symptoms risk factors. diagnosed with if they fulfilled DEWS II criteria symptom score > 12/100 Ocular Surface Disease Index (OSDI) questionnaire, presence any three signs: tear osmolarity 307 mOsm/L either or difference between two eyes 8 mOsm/L, corneal fluorescein staining (CSF) ≥...
The primary aim of this article was to investigate differences in the metabolomic profile tear fluid obtained from pre-operative cataract patients, with or without dry eye disease. objective look for signatures that might discriminate between two groups. A total 222 patients were enrolled study. Eighty-one randomly selected analysis both positive and negative groups, categorized prior surgery. Tear film collected using Schirmer-1 strips analyzed an optimized method developed low-volume...
Purpose The aim of this article was to investigate whether Schirmer strips gathered during clinical dry eye examinations can be prepared for omics analyses in a standardized way, adjust variations tear volume and enable two separate from the same sample. In addition, intention fluorescein dye instillation eyes gave bias effects on metabolomic analysis.
A comprehensive evaluation of oral and ocular symptoms findings in primary Sjögren's syndrome (pSS) patients may provide valuable information for management. Medical history was obtained from female pSS patients, sex- age-matched non-SS with sicca (non-SS controls) as well healthy subjects without complaints (healthy controls). Oral (Summated Xerostomia Inventory, SXI) (McMonnies Dry Eye questionnaire, MDEIS, Ocular Surface Disease Index, OSDI) subjective were recorded. Objective including...
Abstract Understanding the impact of disease on quality life is crucial in patient management. In this cross-sectional study, general and oral health-related questionnaires, thorough examinations ocular dryness were performed age- sex-matched patients with primary Sjögren’s syndrome (pSS group), non-Sjögren’s sicca (non-SS group) healthy controls. General investigated 36-Item Short Form Health Survey 14-Item Oral Impact Profile respectively. Subjective symptoms xerostomia recorded using...
The purpose of this study was to evaluate the diagnostic value inter-eye osmolarity differences in relation dry eye symptoms and other non-osmolar signs disease.One hundred ninety one participants who attended a larger interventional disease prior after cataract surgery were analyzed for (DED). Dry diagnostics performed all subjects according DEWS II criteria: tear collected from both eyes with TearLab system, non-invasive Tear film break up time (NIKBUT) obtained on test Keratograph ocular...
purpose. A previous report has described the use of eye bank storage cultured human limbal epithelial cells (HLECs) to provide a reliable source tissue for treating stem cell deficiency. In present study, conventional organ culture (OC) and Optisol-GS (Bausch & Lomb, Irvine, CA) HLECs were compared. methods. Three-week HLEC cultures either at 31°C or 23°C stored in 5°C closed container 1 week. Morphology was studied by light microscopy transmission electron microscopy, phenotypic...
Purpose: To compare the effect of treatment with preservative-free dexamethasone, NSAIDs and trehalose/hyaluronic acid eye drops preservative benzalkonium chloride containing dexamethasone after cataract surgery in dry versus non-dry eyes. Patients Methods: In this prospective randomized intervention study, tests were performed before 6 weeks surgery. considered as having eye, SDE (sign eye), if at least one following abnormal; corneal fluorescein staining (CFS), non-invasive keratograph...
<b>Aim:</b> To investigate organ culture preservation of cultured limbal epithelial cells in order to enhance the availability tissue-engineered epithelia that are used treat patients with stem cell deficiency. <b>Methods:</b> Limbal were for 3 weeks on intact amniotic membrane fastened a polyester carrier. The stored 1 week at 23°C medium. preserved then examined using colorimetric viability assay, light microscopy and immunohistochemistry. <b>Results:</b> was 84% (20%), no statistically...
<h3>Background/aims:</h3> To assess sterility of cultured human limbal epithelial cells (HLEC) and to investigate the viability, morphology phenotype HLEC following 2 3 weeks organ culture storage. <h3>Methods:</h3> on amniotic membranes were stored in medium a closed container at 23°C. Sterility storage media was tested using Bactec 9240 blood instrument (Becton Dickinson, Maryland) for incubation periodic reading. Viability analysed by calcein-acetoxymethyl ester/ethidium homodimer-1...