A5082402799- Connexins and lens biology
- Intraocular Surgery and Lenses
- Ocular Surface and Contact Lens
- Corneal Surgery and Treatments
- Retinal Development and Disorders
- Corneal surgery and disorders
- Leech Biology and Applications
- Ocular Disorders and Treatments
- Ophthalmology and Visual Impairment Studies
- Developmental Biology and Gene Regulation
- Retinal and Macular Surgery
- Biliary and Gastrointestinal Fistulas
- Esophageal and GI Pathology
- Case Reports on Hematomas
- Inflammatory Bowel Disease
- Allergic Rhinitis and Sensitization
- Ichthyology and Marine Biology
- Cephalopods and Marine Biology
- Mast cells and histamine
- Autoimmune and Inflammatory Disorders
- Shoulder Injury and Treatment
- Medical Malpractice and Liability Issues
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Glaucoma and retinal disorders
- Diverticular Disease and Complications
Oslo University Hospital
2006-2025
University of Oslo
2018-2019
Purpose: To investigate the tear cytokine profile in congenital aniridia, and correlate levels with ophthalmologic findings. Methods: We examined 35 patients aniridia 21 healthy controls. Tear fluid was collected Schirmer I test capillary tubes from each eye, concentration of 27 inflammatory cytokines determined using multiplex bead assay. Eyes all participants were tests for dry eye disease, including evaluation meibomian glands (meibography). Differences between two groups analyzed,...
SummaryBackground & aimsStudies have suggested that supplementation with docosahexaenoic acid (DHA) to preterm infants might be associated an increased risk of bronchopulmonary dysplasia (BPD). Our aim was investigate the effect enteral arachidonic (ARA) and DHA on short-term respiratory outcomes neonatal morbidities in very infants.MethodsThis is a secondary analysis data from ImNuT (Immature, Nutrition Therapy) study, randomized double blind clinical trial. Infants gestational age less...
Purpose: To investigate the association between PAX6 genotype and macular morphology in congenital aniridia. Methods: The study included 37 participants (15 males) with aniridia (aged 10–72 years) 58 age-matched normal controls (18 males). DNA was isolated from saliva samples. exons, intron/exon junctions, known regulatory regions were amplified PCR sequenced. Multiplex ligation-dependent probe amplification (MLPA) performed to detect larger deletions or duplications cis-regulatory regions....
Objective. To assess the need for intestinal repeat resection recurrence of Crohn's disease in patients observed more than 20 years after first resection. Material and methods. Data were gathered retrospectively from medical records 53 (28 F) consecutive with May 1954 to December 2002. Median age at was 24.5 (range 13–65) years, median observation time thereafter 26.5 (20.1–48.6) years. Disease location behaviour defined according Vienna classification. Results. The had an average 2.7 a 2...
Aims To investigate the aetiology and characteristics of dry eye disease (DED) in a Nordic cohort patients with congenital aniridia. Methods Thirty-four Norwegian one Danish subject aniridia 21 healthy controls were examined. All subjects underwent an extensive examination, including evaluation meibomian glands (MGs) by meibography, measurement tear production film osmolarity grading vital staining ocular surface. Moreover, slit-lamp biomicroscopy was undertaken, aniridia-associated...
Purpose: To assess color vision and its association with retinal structure in persons congenital aniridia. Methods: We included 36 aniridia (10–66 years), 52 healthy, normal trichromatic controls (10–74 years) the study. Color was assessed Hardy-Rand-Rittler (HRR) pseudo-isochromatic plates (4th ed., 2002); Cambridge Test a low-vision version of Assessment Diagnosis test (CAD-LV). Cone-opsin genes were analyzed to confirm versus deficiencies. Visual acuity ocular media opacities assessed....
Abstract Meibomian gland dysfunction (MGD) is the most common cause of dry eye disease (DED). In this study, we aimed to compare effects eyelid warming treatment using either TheraPearl Eye Mask (Bausch & Lomb Inc., New York, USA) or Blephasteam (Spectrum Thea Pharmaceuticals LTD, Macclesfield, UK) in a Norwegian population with mild moderate MGD-related DED. An open label, randomized comparative trial seventy patients (49 females, 21 males; mean age 53.6 years). Patients were randomly...
We report on two brothers with visual impairment, and non-syndromic alopecia in the elder proband. The parents were first-degree Pakistani cousins. Whole exome sequencing of brother parents, followed by Sanger all four family members, led to identification variants responsible for phenotypes. One variant was a homozygous nonsense inhibitory subunit cone-specific cGMP phosphodiesterase gene, PDE6H:c.35C>G (p.Ser12*). PDE6H is expressed cones retina, which are involved perception color vision....
Purpose: To investigate fundus autofluorescence (FAF) and other manifestations in congenital aniridia. Methods: Fourteen patients with aniridia 14 age- sex-matched healthy controls were examined. FAF images obtained an ultra-widefield scanning laser ophthalmoscope. intensity was quantified the macular fovea a ring surrounding related to internal reference within each image. All underwent ophthalmologic examination, including optical coherence tomography slit-lamp biomicroscopy. Results: Mean...
Purpose: To characterize the association between dark-adapted rod and cone sensitivity retinal structure in PAX6-related aniridia. Methods: Dark-adaptation curves were measured after a 5-minute exposure to bright light with red (625 nm) green (527 2° circular stimuli presented at ≈20° temporal eccentricity 27 participants aniridia (nine males; 11–66 years old) 38 age-matched healthy controls. A two-stage exponential model was fitted each participant's responses determine their thresholds...
To investigate the changes in tear cytokine profile of patients with meibomian gland dysfunction (MGD) treated eyelid warming and to correlate these clinical parameters for dry eye disease (DED). Seventy MGD were included eyelids. Of these, 61 still used treatment three months after baseline, while 48 completed whole period six months. The concentrations 39 cytokines fluid measured at baseline treatment. All participants examined tests DED, including film break-up time (TBUT), ocular surface...
Congenital aniridia is a rare genetic disorder of the eye characterized by visual impairment and progressive vision loss. While prior research has focused on ocular manifestations in individuals with aniridia, there dearth impacts cognition mental health. The aims this study were to describe subjective symptoms everyday executive functioning, fatigue sleepiness adults compare self-reported health status that normative reference group.Twenty-nine (aged 18-79 years) congenital included online...
Abstract Purpose Congenital aniridia is a serious eye disease characterized by absence of iris to various degrees. The aims this study were investigate health‐related quality life (HRQoL) in adults with and assess the relationships between HRQoL, psychological status, ocular health obesity. Methods Twenty‐nine congenital (48% male, aged 18–79 years) participated. HRQoL was measured SF‐36 EQ visual analogue scale (VAS). physical (PCS) mental (MCS) component summaries calculated higher scores...