A5008567339- Ophthalmology and Visual Impairment Studies
- Visual perception and processing mechanisms
- Retinal Development and Disorders
- Retinal Diseases and Treatments
- Color Science and Applications
- Corneal surgery and disorders
- Glaucoma and retinal disorders
- Intraocular Surgery and Lenses
- Color perception and design
- Connexins and lens biology
- Retinal Imaging and Analysis
- Augmented Reality Applications
- Ergonomics and Musculoskeletal Disorders
- Infrared Target Detection Methodologies
- Virtual Reality Applications and Impacts
- Neural dynamics and brain function
- Corneal Surgery and Treatments
- Retinopathy of Prematurity Studies
- Ophthalmology and Visual Health Research
- melanin and skin pigmentation
- Ocular and Laser Science Research
- Circadian rhythm and melatonin
- Photoacoustic and Ultrasonic Imaging
- Developmental Biology and Gene Regulation
- Leech Biology and Applications
University of South-Eastern Norway
2016-2025
Pennsylvania State University
2023
Zenitel (Norway)
2023
KTH Royal Institute of Technology
2023
Karolinska Institutet
2023
Avinet (Norway)
2023
Sandvik (Norway)
2023
University of Houston
2023
University of Bradford
2022
University of Leeds
2022
The prevalence of myopia is increasing extensively worldwide. number people with in 2020 predicted to be 2.6 billion globally, which expected rise up 4.9 by 2050, unless preventive actions and interventions are taken. individuals high also substantially pathological become the most common cause irreversible vision impairment blindness worldwide Europe. These estimates indicate importance reducing burden means control prevent onset slow down progression. Due urgency situation, European...
Abstract East Asia has experienced an excessive increase in myopia the past decades with more than 80% of younger generation now affected. Environmental and genetic factors are both assumed to contribute development refractive errors, but etiology is unknown. The environmental factor argued be greatest importance preventing high levels daylight exposure. If true, prevalence would higher adolescents living latitude countries fewer hours autumn-winter. We examined errors a representative...
Tritan color-vision deficiency is an autosomal dominant disorder associated with mutations in the short-wavelength-sensitive- (S-) cone-pigment gene. An unexplained feature of that individuals same mutation manifest different degrees deficiency. To date, it has not been possible to examine whether any loss S-cone function accompanied by physical disruption cone mosaic. Two related tritan subjects novel their S-cone-opsin gene, but deficiency, were examined. Adaptive optics was used obtain...
Missense mutations in the cone opsins have been identified as a relatively common cause of red/green color vision defects, with most frequent mutation being substitution arginine for cysteine at position 203 (C203R). When corresponding is mutated rhodopsin, it disrupts proper folding pigment, causing severe, early onset retinitis pigmentosa. While C203R has associated loss function deficiency, not known what happens to cones expressing this mutant opsin. Here, we used high-resolution retinal...
Purpose: To investigate the tear cytokine profile in congenital aniridia, and correlate levels with ophthalmologic findings. Methods: We examined 35 patients aniridia 21 healthy controls. Tear fluid was collected Schirmer I test capillary tubes from each eye, concentration of 27 inflammatory cytokines determined using multiplex bead assay. Eyes all participants were tests for dry eye disease, including evaluation meibomian glands (meibography). Differences between two groups analyzed,...
Purpose: To investigate the association between PAX6 genotype and macular morphology in congenital aniridia. Methods: The study included 37 participants (15 males) with aniridia (aged 10–72 years) 58 age-matched normal controls (18 males). DNA was isolated from saliva samples. exons, intron/exon junctions, known regulatory regions were amplified PCR sequenced. Multiplex ligation-dependent probe amplification (MLPA) performed to detect larger deletions or duplications cis-regulatory regions....
Purpose To characterize retinal structural biomarkers for progression in adult-onset Stargardt disease from multimodal imaging in-vivo maps. Methods Seven adult patients (29–69 years; 3 males) with genetically-confirmed and clinically diagnosed age-matched healthy controls were imaged confocal non-confocal Adaptive Optics Scanning Light Ophthalmoscopy (AOSLO), optical coherence tomography (OCT), fundus infrared (FIR), short wavelength-autofluorescence (FAF) color photography (CFP). Images...
Monocular blur sometimes impairs locomotion; however, it is not always clear when this will happen. Optic flow (the apparent motion of scene texture elements that occurs during self-motion) provides powerful signals about the direction travel. Here, we test whether monocular heading perception from optic compared to full vision under various levels degradation. Participants ( N = 52, mean age 30 years) completed contrast sensitivity, visual acuity, and tasks with rich or degraded flow,...
In syndromic forms of myopia caused by long (L) to middle (M) wavelength (L/M) interchange mutations, erroneous contrast signals from ON-bipolar cells activated cones with different levels opsin expression are suggested make the eye susceptible increased growth. This susceptibility is modulated L:M cone ratio. Here, we examined L and M genes, ratios their association common refractive errors in a population low prevalence. Cycloplegic autorefraction ocular biometry were obtained for...
Parafoveal function is important for daily visual tasks such as reading. Here the variability in cone density along four cardinal meridians parafoveal regions of retina was investigated vivo using an adaptive optics fundus camera. Ten healthy normal trichromatic individuals were included study. There significant differences between at all tested eccentricities (0.5, 1, 2 and 3°) meridians. Cone ranged from 34,900 to 63,000 cones/mm(2) 1° horizontally, 31,600 60,700 vertically. The results...
Purpose: To characterize the association between foveal shape and cone retinal pigment epithelium (RPE) cell topographies in healthy humans. Methods: Multimodal adaptive scanning light ophthalmoscopy optical coherence tomography (OCT) were used to acquire images of cones, RPE cells, layers eyes 23 participants with normal foveas. Distributions densities fitted nonlinear mixed-effects models. A linear model was examine relationship inter-cell distances as obtained from OCT scans thickness....
Oligocone trichromacy (OT) is an unusual cone dysfunction syndrome characterized by reduced visual acuity, mild photophobia, amplitude of the electroretinogram with normal rod responses, fundus appearance, and or near-normal color vision. It has been proposed that these patients have a number functioning cones (oligocone). This paper sought to evaluate integrity photoreceptor mosaic in four previously described as having OT.Retinal images were obtained from two brothers (13 15 years)...
Abstract Purpose To compare axial length (AL) and corneal radius (CR) measured with the Oculus Myopia Master Zeiss IOLMaster 700, cycloplegic refractive error Huvitz Auto Ref/Keratometer (HRK‐8000A). Methods The study included both eyes of 74 participants (16 male), a mean (SD) age 22.8 (3.7) years. parameters indicated were under cycloplegia these instruments: (AL, CR error), 700 (AL CR) HRK‐8000A (refractive CR). Bland–Altman plots mixed effects 95% limits agreement (LoA) corresponding...
Aims To investigate the aetiology and characteristics of dry eye disease (DED) in a Nordic cohort patients with congenital aniridia. Methods Thirty-four Norwegian one Danish subject aniridia 21 healthy controls were examined. All subjects underwent an extensive examination, including evaluation meibomian glands (MGs) by meibography, measurement tear production film osmolarity grading vital staining ocular surface. Moreover, slit-lamp biomicroscopy was undertaken, aniridia-associated...
To examine, in Norwegian adolescents, to what degree emmetropia and low hyperopia were maintained from 16 18 years of age, if this was the case, whether it associated with continued coordinated ocular growth.Cycloplegic autorefraction biometry, including crystalline lens thickness, measured 93 adolescents (mean age: 16.7 ± 0.3 years; 63.4% females) repeated after 2 years. Crystalline power determined by ray tracing over a 1-mm pupil, based on Gullstrand-Emsley model. Serum vitamin D3...
Background Small hard macular drusen can be observed in the retina of adults as young 18 years age. Here, we seek to describe vivo topography and geometry these drusen. Methods Retinal images were acquired young, healthy using colour fundus photography, spectral domain optic coherence tomography (SD-OCT), reflectance flood-illuminated adaptive ophthalmoscopy (AO flood) scanning light (AOSLO) both confocal non-confocal split-detection modalities. bright yellow within a 10 degree radius from...
Full accessibility to eXtended Reality Head-Mounted Displays (XR HMDs) includes a requirement for well-functioning eyes and visual system. Eye vision problems—that affect skills abilities various degrees—are common may prevent an individual from comfortably wearing using XR HMDs. Yet, problems have gained little attention in the community, making it difficult assess degree of how increase inclusivity. This perspective article aims highlight need understanding, assessing, correcting eye...