A5101690759- Glaucoma and retinal disorders
- Corneal surgery and disorders
- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Corneal Surgery and Treatments
- Ocular Surface and Contact Lens
- Ophthalmology and Visual Impairment Studies
- Retinal and Optic Conditions
- Intraocular Surgery and Lenses
- Ocular Diseases and Behçet’s Syndrome
- Ocular Infections and Treatments
- Retinal Development and Disorders
- Retinal and Macular Surgery
- Ocular and Laser Science Research
- Traumatic Ocular and Foreign Body Injuries
- Cerebral Venous Sinus Thrombosis
- Multiple Myeloma Research and Treatments
- Drug-Induced Ocular Toxicity
- Ocular Oncology and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Systemic Lupus Erythematosus Research
- Retinopathy of Prematurity Studies
- RNA regulation and disease
- Hungarian Social, Economic and Educational Studies
- Visual perception and processing mechanisms
Semmelweis University
2016-2025
Clinical Trial Investigators
2023
Eötvös Loránd University
2023
Markusovszky Egyetemi Oktatókórház
2019
Maastricht University Medical Centre
2018
Maastricht University
2018
University Hospital and Clinics
2018
Hospital of the Brothers of St. John of God
2018
Vienna Institute for Research in Ocular Surgery
2018
Antwerp University Hospital
2018
An international, expert-led consensus initiative to develop systematic, evidence-based recommendations for the treatment of noninfectious uveitis in era biologics.The availability biologic agents human eye disease has altered practice patterns management uveitis. Current guidelines are insufficient assure optimal use noncorticosteroid systemic immunomodulatory agents.An international expert steering committee comprising 9 specialists (including both ophthalmologists and rheumatologists)...
The prevalence of myopia is increasing extensively worldwide. number people with in 2020 predicted to be 2.6 billion globally, which expected rise up 4.9 by 2050, unless preventive actions and interventions are taken. individuals high also substantially pathological become the most common cause irreversible vision impairment blindness worldwide Europe. These estimates indicate importance reducing burden means control prevent onset slow down progression. Due urgency situation, European...
The global prevalence of myopia is predicted to approach 50% by 2050, increasing the risk visual impairment later in life. No pharmacologic therapy approved for treating childhood progression.To assess safety and efficacy NVK002 (Vyluma), a novel, preservative-free, 0.01% 0.02% low-dose atropine formulation progression.This was double-masked, placebo-controlled, parallel-group, randomized phase 3 clinical trial conducted from November 20, 2017, through August 22, 2022, placebo vs atropine,...
The purpose of this study was to evaluate the alteration keratometric, pachymetric, and elevation parameters keratoconic normal corneas with Pentacam Scheimpflug camera.Pentacam measurements were performed on 41 eyes 24 patients keratoconus 70 subjects. In each eye, keratometric values, central minimal pachymetry, anterior posterior evaluated. Receiver operating characteristic curves used compare sensitivity specificity different parameters. Predictors data evaluated by logistic regression...
Neuronal circuit asymmetries are important components of brain circuits, but the molecular pathways leading to their establishment remain unknown. Here we found that mutation FRMD7, a gene is defective in human congenital nystagmus, leads selective loss horizontal optokinetic reflex mice, as it does humans. This accompanied by direction selectivity retinal ganglion cells and transition from asymmetric symmetric inhibitory input direction-selective cells. In wild-type retinas, FRMD7...
Purpose To describe the topographic and tomographic characteristics of normal fellow eyes unilateral keratoconus cases to evaluate accuracy machine learning classifiers in discriminating healthy corneas from corneas. Setting Department Ophthalmology, Semmelweis University, Budapest, Hungary. Design Retrospective case-control study. Methods Patients with bilateral (keratoconus group), clinically according indices Pentacam HR Scheimpflug camera; patients (fellow-eye group); refractive surgery...
Purpose To compare the efficacy of perioperative treatment strategies, in addition to topical bromfenac 0.09% and dexamethasone 0.1%, reduce risk for developing cystoid macular edema (CME) after uneventful cataract surgery diabetic patients. Setting Twelve European study centers. Design Randomized clinical trial. Methods Diabetic patients having phacoemulsification were randomly allocated receive no additional treatment, a subconjunctival injection with 40 mg triamcinolone acetonide, an...
To evaluate the macular thickness, choroidal and visual acuity changes in eyes of patients with bilateral chronic central serous chorioretinopathy during eplerenone treatment.This prospective clinical trial was conducted on chorioretinopathy, who had subretinal fluid (SRF) 1 eye. Twenty-eight were treated 50 mg/day oral for 3 months observed another months. SRF compared 28 fellow pachychoroid pigment epitheliopathy.The thickness showed a significant decrease (P < 0.005) at all eyes, but...
Stargardt disease is a currently untreatable, inherited neurodegenerative that leads to macular degeneration and blindness due loss-of-function mutations in the ABCA4 gene. We have designed dual adeno-associated viral vector encoding split-intein adenine base editor correct most common mutation (c.5882G>A, p.Gly1961Glu). optimized editing human models, including retinal organoids, induced pluripotent stem cell-derived pigment epithelial (RPE) cells, as well adult explants RPE/choroid vitro....
Bevezetés: Az intraokuláris, és ezen belül a sugártest-daganatok differenciáldiagnosztikája mai napig nehézségeket okozhat, ugyanis tumor sclera mögött növekszik, többnyire későn okoz tüneteket. Esetismertetés: Egy 22 éves nőbeteg esetét ismertetjük, aki azzal panasszal jelentkezett klinikánkon, hogy 4 hónapja homályosan lát jobb szemével. A réslámpás ultrahangos vizsgálat sugártestből kiinduló pigmentált, ovális alakú terimét mutatott, amely alapján uvealis melanoma malignumot...
Az Alport-szindróma a bazálmembrán IV. típusú kollagénjének örökletes zavara, amely progresszív vesekárosodást, szenzorineurális hallásromlást, szaruhártya, szemlencse és retinaeltéréseket okozhat. A szem eltérései közül gyakori visszatérő corneaerózió, az anterior lenticonus, perifériás retinán megjelenő pigmentzavar: „dot and fleck” retinopathia. Esetismertetés: 38 éves férfi betegünk két hónapja tartó foltlátás miatt jelentkezett klinikánkon. Anamnézisében krónikus glomerulonephritis...
To measure corneal density and evaluate haze in unoperated eyes after photorefractive keratectomy (PRK).Forty-nine patients (91 eyes) who underwent PRK 48 control (76 were measured with the densitometry program of Pentacam Scheimpflug imaging system (Oculus Optikgeräte GmbH) (0=no clouding, 100=tissue completely opaque). Eyes categorized as myopic or hyperopic (myopia group hyperopia group), subgroups defined (unoperated myopia postoperative clear corneas (clear cornea group). The ANOVA...
To compare anterior chamber parameters in normal eyes and with mild to moderate keratoconus corneas using rotating Scheimpflug imaging evaluate trends corneal protrusion progression.Department of Ophthalmology, Semmelweis University, Budapest, Hungary.The depth (ACD) at the center, thinnest point cornea, 1.0 mm, 2.0 3.0 mm paracentrally; central pachymetry; posterior elevation were measured by (Pentacam) refractive surgery candidates. A generalized estimating equation (GEE) was used identify...
Objective The purpose of this study was to evaluate the possible structural changes macula in patients with unilateral amblyopia using optical coherence tomography (OCT) image segmentation. Patients and Methods 38 consecutive (16 male; mean age 32.4±17.6 years; range 6–67 years) were involved study. OCT examinations performed a time-domain device, custom-built analysis software (OCTRIMA) used for axial length (AL) measured by LenStar LS 900 device. Macular layer thickness, AL manifest...
This study aimed to determine the relationship between image quality and measurement repeatability of optical coherence tomography angiography (OCTA) parameters in patients with non-proliferative diabetic retinopathy.A total 100 eyes 50 were included study. Three OCTA images obtained consecutively during one session imaging all using RTVue AngioVue device. We applied signal strength index (SSI) provided by system define scan quality. Superficial vessel density (VD) central 3 × mm macular...
Purpose During life up to 70% of aniridia subjects develop aniridia-associated keratopathy (AAK). AAK is characterized by limbal stem cell insufficiency, impaired corneal epithelial differentiation and abnormal adhesion, which leads centripetal spreading vascularization, conjunctivalization, thickening the cornea. Our aim was examine subbasal nerve plexus central stromal microstructure in with congenital aniridia, using vivo confocal laser scanning microscopy CLSM.
Purpose To investigate corneal sensitivity to selective mechanical, chemical, and thermal stimulation evaluate their relation dry eye symptoms in patients with keratoconus. Methods Corneal thresholds were determined using a gas esthesiometer 19 keratoconus (KC group) 20 age-matched healthy subjects (control group). Tear film dynamics was assessed by Schirmer I test the non-invasive tear breakup time (NI-BUT). All eyes examined rotating Scheimpflug camera assess severity. Results KC had...
PURPOSE: To evaluate and compare the mechanical properties of anterior capsule openings performed with continuous curvilinear capsulorhexis (CCC) technique femtosecond laser capsulotomy (FLC) in ex vivo porcine lens specimens. METHODS: Fresh eyes were included study (CCC group, n = 50; FLC 30). The stretched universal testing equipment until they ruptured. rupture force circumference stretching ratio evaluated. morphologic profile cut edges was evaluated using scanning electron microscopy...
Purpose To assess the correlation between keratoconus severity and intereye asymmetry of pachymetric data posterior elevation values to evaluate their combined accuracy in discriminating normal corneas from those with keratoconus. Methods This study included 97 patients: 65 subjects bilateral (NC) 32 (KC). Central corneal thickness (CCT), thinnest (ThCT) (PE) at point cornea were measured both eyes using Scheimpflug imaging. Intereye its calculated for each variable. The area under receiver...